A systematic review on botany, ethnopharmacology, quality control, phytochemistry, pharmacology and toxicity of Arctium lappa L. fruit

Jin, Xingyue; Liu, Suyi; Chen, Shujing; Wang, Lirong; Yan, Chunze; He, Jun; Fang, Shiming; Li, Jin; Chang, Yan‐xu

doi:10.1016/j.jep.2023.116223

Cited by 8 publications

(4 citation statements)

References 145 publications

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“…During the experiment period, the control group did not receive any treatment. In contrast, the ESC group was given an intramuscular injection of 0.15 mL 2×10 6 Ehrlich cells in the thigh of the left hind leg [7][8][9]. In the ESC group treated with arctiin, we induced ESC in rats.…”

Section: Animals' Treatmentmentioning

confidence: 99%

“…This plant is commonly used as a vegetable in Asian countries and is a popular ingredient in traditional European dishes [ 5 ]. Various studies have shown that arctiin possesses several properties, including anti-proliferative, anti-senescence, anti-oxidative, anti-tumor, toxic, anti-adipogenic, and anti-bacterial effects [ 6 ]. Therefore, this study aimed to investigate the in vivo anti-cancer effects of arctiin in rats with ESC tumors.…”

Section: Introductionmentioning

confidence: 99%

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Arctiin Inhibits Inflammation, Fibrosis, and Tumor Cell Migration in Rats With Ehrlich Solid Carcinoma

Alfair,

Jabarti,

Albalawi

et al. 2023

Cureus

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Background and objectives: ESC or Ehrlich solid carcinoma is a type of tumor originating from a spontaneous mammary adenocarcinoma in mice. It is a highly aggressive and fast-growing carcinoma that can create a solid mass when inserted under the skin. Its solid, undifferentiated form makes it an ideal model for researching cancer biology, tumor immunology, and testing various anti-cancer treatments. Additionally, arctiin has multiple beneficial properties, such as anti-proliferative, anti-oxidative, anti-adipogenic, and anti-bacterial. This study aimed to explore the potential anti-cancer benefits of arctiin in rats with ESC while also analyzing its effects on cell fibrosis markers, tumor cell migration, and inflammasome pathways. Methods: Rats were given a tumor in their left hind limb via an intramuscular injection consisting of 2×10 6 cells. After eight days, some of the rats received a daily oral dose of 30 mg/kg of arctiin for three weeks. Muscle samples were observed under an electron microscope or stained with hematoxylin/eosin. Additionally, gene expression and protein levels of toll-like receptor 4 (TLR4), NLR family pyrin domain containing 3 (NLRP3), signal transducer and activator of transcription 3 (STAT3), transforming growth factor (TGF)-β, endothelial growth factor (VEGF), and cyclin D1 were assessed in another part of the muscle samples. Results: When ESC rats were given arctiin as a treatment, their mean survival time increased and their tumor volume and weight decreased. Additionally, when tumor tissue was examined under an electron microscope, it showed signs of pleomorphic cells, necrosis, nuclear fragmentation, membrane damage with cytoplasmic content spilling, and loss of cellular junction. The stained sections with hematoxylin/eosin showed a dense cellular mass and compressed, degenerated, and atrophied muscle. However, treatment with arctiin improved all these effects. Finally, the expression of TLR4, NLRP3, STAT3, TGF-β, VEGF, and cyclin D1 was significantly reduced with arctiin treatment. Conclusions: Through the use of arctiin, tumor size and weight were effectively reduced, leading to an increase in the average survival time of rats and an improvement in muscle structure. Additional research has shown that arctiin is able to suppress inflammation, fibrosis, and the migration of tumor cells by inhibiting STAT3, TGF-β1, TLR4, NLRP3, VEGF, and cyclin D1.

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Section: Animals' Treatmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Arctiin Inhibits Inflammation, Fibrosis, and Tumor Cell Migration in Rats With Ehrlich Solid Carcinoma

Alfair,

Jabarti,

Albalawi

et al. 2023

Cureus

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“…The plant contains flavonoids and lignans, which are beneficial for treating high blood pressure, gout, thrombosis, hepatitis, and inflammatory diseases. Various biological properties, including antimutagenic, anticancer, and rejuvenating properties, are also attributed to its phenolic components [ 45 ]. Modern research reveals that A. lappa contains organic acids, flavonoids, terpenoids, lignans, and other components [ 46 ].…”

Section: Introductionmentioning

confidence: 99%

The Biological Active Substances of Taraxacum officinale and Arctium lappa from the Siberian Federal District

Frolova,

Fokina,

Milentyeva

et al. 2024

IJMS

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Currently, scientists are increasingly focusing on utilizing the natural flora of the planet to search for and isolate individual bioactive substances that prevent various diseases, contribute to increased life expectancy, and affect all major life-supporting systems in the human body. This study describes the examination of the composition of plant raw materials from the Siberian Federal District. The research focuses on plant specimens from the root parts of Taraxacum officinale and Arctium lappa, collected in the Kemerovo region. The study determines the contents of the water-soluble vitamins B and C in the research subjects. The investigation includes assessing antioxidant properties, antimicrobial activity, and flavonoid content in extracts based on plant raw materials. All samples show a high percentage of antioxidant activity, with the highest antioxidant activity for T. officinale at 85.51 and that for A. lappa at 88.97. The results indicate low antimicrobial activity against Escherichia coli (growth inhibition zone up to 15.5 mm). Plant extracts contain significant amounts of B-group vitamins, with pyridoxine in T. officinale (156.40 μg/mL) and thiamine (46.20 μg/mL) and pyridoxine (357.10 μg/mL) in Arctium lappa. Flavonoids (rutin and quercetin) are identified in T. officinale and A. lappa extracts based on the study results.

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“…Astragaloside IV, a saponin from Astragalus polysaccharides restrains growth and invasion of cervical cancer cells [ 9 ]. Arctium lappa L. a biennial plant, is a traditional Chinese herbal medicine [ 10 ], which has exhibited inhibitory effect on various cancers. For instance, Taleb et al [ 11 ] report that the extracts of aerial parts of Arctium lappa L. exerts a proapoptotic and antiangiogenic activities on breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Arctigenin hinders the invasion and metastasis of cervical cancer cells via the FAK/paxillin pathway

Liao

Liu

et al. 2023

Heliyon

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A systematic review on botany, ethnopharmacology, quality control, phytochemistry, pharmacology and toxicity of Arctium lappa L. fruit

Cited by 8 publications

References 145 publications

Arctiin Inhibits Inflammation, Fibrosis, and Tumor Cell Migration in Rats With Ehrlich Solid Carcinoma

Arctiin Inhibits Inflammation, Fibrosis, and Tumor Cell Migration in Rats With Ehrlich Solid Carcinoma

The Biological Active Substances of Taraxacum officinale and Arctium lappa from the Siberian Federal District

Arctigenin hinders the invasion and metastasis of cervical cancer cells via the FAK/paxillin pathway

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