A Systematic Review on Crosstalk Between Microbiome and Immune System

Aparna, Y.; Anuradha, K.; Anju, S.; Sarada, J.

doi:10.1007/978-981-16-3156-6_3

Cited by 2 publications

(2 citation statements)

References 60 publications

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“…Another area of active research is the investigation of the crosstalk between the microbiome and the immune system [262]. The microbiome has been shown to influence immune responses, and dysbiosis (an imbalance in the microbiome) has been associated with increased susceptibility to infections [90].…”

Section: Innovative Treatment Strategies Targeting the Microbiomementioning

confidence: 99%

Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

Kamel,

Aleya,

Alsubih

et al. 2024

JPM

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Infectious diseases have long posed a significant threat to global health and require constant innovation in treatment approaches. However, recent groundbreaking research has shed light on a previously overlooked player in the pathogenesis of disease—the human microbiome. This review article addresses the intricate relationship between the microbiome and infectious diseases and unravels its role as a crucial mediator of host–pathogen interactions. We explore the remarkable potential of harnessing this dynamic ecosystem to develop innovative treatment strategies that could revolutionize the management of infectious diseases. By exploring the latest advances and emerging trends, this review aims to provide a new perspective on combating infectious diseases by targeting the microbiome.

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Section: Innovative Treatment Strategies Targeting the Microbiomementioning

confidence: 99%

Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

Kamel,

Aleya,

Alsubih

et al. 2024

JPM

View full text Add to dashboard Cite

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“…Pattern recognition receptors (PRRs) are an intrinsic part of the immune system that communicates with the microbiota and maintains homeostasis. For instance, TLRs (Toll-like receptors) and NLRs (nuclear oligomerization domainlike receptors) are examples of PRRs that identify microbe-associated molecular patterns (MAMPs) like microbial RNA/DNA, lipid A, peptidoglycan and flagella and trigger various downstream signalling pathways (Aparna et al 2021). The absence of particular PRRs can cause alteration in the microbial composition and defects in the intestinal barrier, thereby contributing to microbial invasion of organs.…”

Section: Does the Immune System Have Any Influence On The Diversity O...mentioning

confidence: 99%

Deciphering the interdependent labyrinth between gut microbiota and the immune system

Saini

Dalal

Sharma

2022

Letters in Applied Microbiology

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The human gut microbiome interacts with each other and the host, which has significant effects on health and disease development. Intestinal homeostasis and inflammation are maintained by the dynamic interactions between gut microbiota and the innate and adaptive immune systems. Numerous metabolic products produced by the gut microbiota play a role in mediating cross‐talk between gut epithelial and immune cells. In the event of an imbalance between the immune system and microbiota, the body becomes susceptible to infections and homeostasis is compromised. This review mainly focuses on the interplay between microbes and the immune system, such as T‐cell‐ and B‐cell‐mediated adaptive responses to microbiota and signalling pathways for effective communication between the two. We have also highlighted the role of microbes in the activation of the immune response, the development of memory cells and how the immune system determines the diversity of human gut microbiota. The review also explains the relationship of commensal microbiota and their relation to the production of immunoglobulins.

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A Systematic Review on Crosstalk Between Microbiome and Immune System

Cited by 2 publications

References 60 publications

Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

Microbiome Dynamics: A Paradigm Shift in Combatting Infectious Diseases

Deciphering the interdependent labyrinth between gut microbiota and the immune system

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