A Systematic Review on Human Monkeypox Virus Disease and Infection in Pregnancy

Morris, Srishti; Joshi, Poonam; Soni, Priyanka; Jakhmola, Vikas; Sahiba,; Kalita, Karabi; Nainwal, Nidhi; Sharma, Nitin

doi:10.22207/jpam.17.2.52

J. Pure Appl. Microbiol.

2023

DOI: 10.22207/jpam.17.2.52

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A Systematic Review on Human Monkeypox Virus Disease and Infection in Pregnancy

Srishti Morris,

Poonam Joshi,

Priyanka Soni

et al.

Abstract: The monkeypox virus (MPXV) has become a dangerous zoonosis. The fast spread of MPXV occurred in the last two years. The number of cases remarkably increased in 2022. The reasons behind the sudden increase in MPXV cases are multifactorial. Monkeypox (MPOX) a viral zoonotic illness, is caused by MPXV. It is an enveloped, linear, double-stranded DNA virus. MPXV transmission may take place by direct contact with humans or animals. This article summarizes a better understanding of the spread of MPXV infections. Pre… Show more

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Cited by 3 publications

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A new compartmentalized epidemic model to analytically study the impact of awareness on the control and mitigation of the monkeypox disease

Idisi,

Yusuf,

Adeniyi

et al. 2023

Healthcare Analytics

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A new compartmentalized epidemic model to analytically study the impact of awareness on the control and mitigation of the monkeypox disease

Idisi,

Yusuf,

Adeniyi

et al. 2023

Healthcare Analytics

View full text Add to dashboard Cite

From Outbreaks to Artificial Intelligence: A Comprehensive Review of Monkeypox Virus Epidemiology, Diagnosis, Treatment, Vaccination, and Deep Learning Applications

Ahmadi,

Amirzadeh,

Ahmadi

et al. 2024

Journal of Tropical Medicine

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Objectives: After the global impact of the COVID‐19 pandemic, concerns over virus transmission have risen. A state of health emergency was declared in 2022 due to Clade 2 of the monkeypox (MPOX) virus. In August 2024, another emergency was declared by the World Health Organization (WHO) because of the widespread Clade 1b, which caused a more severe and lethal disease. This review synthesizes current MPOX knowledge to assist policymakers, clinicians, and researchers in developing effective diagnostics, therapeutic interventions, vaccination strategies, and outbreak management.Methods: This systematic review study searched for articles on virus epidemiology, virology, clinical features, transmission routes, available drugs and vaccines, and new artificial intelligence (AI) applications in diagnosis and drug discovery.Results: MPOX virus is a 200–250‐nm, double‐stranded DNA (ds‐DNA) virus that causes smallpox‐like skin lesions. Tecovirimat is the primary drug for severe cases, especially in people with suppressed immune systems. Smallpox vaccines can help prevent MPOX infection because of the genetic similarities between the MPOX and smallpox viruses. AI‐based models can assist medical teams in promptly diagnosing MPOX skin lesions, improving decision‐making for treatment.Conclusion: This review highlights the importance of using traditional public health knowledge alongside modern AI to manage MPOX outbreaks effectively. It shows that we need strong public health policies, focused interventions, and ongoing research on how AI can help control infectious diseases.

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Multi-organ clinical manifestations of Mpox: an umbrella review of systematic reviews

Satapathy,

Khatib,

Gaidhane

et al. 2024

BMC Infect Dis

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Background Mpox is a severe viral zoonosis that has emerged as a public health concern due to its potential for human-to-human transmission and severe illness. Understanding its clinical manifestations is crucial for effective management and control. Several systematic reviews have assessed various manifestations of Mpox. This umbrella review synthesizes evidence on Mpox’s manifestations across different organ systems. Method We conducted an umbrella review, adhering to Joanna Briggs Institute (JBI) methodology and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, focusing on systematic reviews of Mpox manifestations. We performed a literature search up to 25th September 2023, in databases like PubMed, Embase, and Web of Science. We included systematic reviews of observational studies, case reports, case series, or RCTs reporting any manifestations of Mpox in humans, focusing on a global scope. AMSTAR 2 was used to evaluate the quality of systematic reviews, and data has been synthesized in narrative and tabular manners. Results A total of 25 systematic reviews were included, uncovering diverse manifestations of Mpox, such as cutaneous, cardiovascular, oral, ophthalmic, gastrointestinal, respiratory, and pregnancy-related. Cutaneous manifestations (up to 100%) were the most prevalent, featuring lesions and rashes. Constitutional symptoms of viral illness were reported in ~ 60% to > 85% of the cases. Significant respiratory symptoms were present in ~ 50% of cases overall. Headaches were the leading neurological symptom present in > 30%. Symptoms of gastrointestinal involvement ranged from 39% (oral lesions) with decreasing frequency to low diarrhea at ~ 5%, with proctitis percentages ranging from high teens to mid-twenties. Ophthalmic manifestations (6% but with wide variations among studies). Many primary studies included in the systematic reviews consisted of case reports and case series. A wide range of manifestations across different organ systems was observed. Negative outcomes for pregnancies were reported, but evidence is limited. Adverse cardiovascular and neurological outcomes were identified, though only a few studies provided insights into these findings. Conclusion Mpox exhibits diverse manifestations, impacting multiple organ systems, with substantial variations. The findings highlight the importance of ongoing, nuanced, and region-specific research and management strategies for Mpox. The reliance on case reports and series underscores the need for more high-quality, long-term studies to deepen our understanding and management of this significant public health concern. Supplementary Information The online version contains supplementary material available at 10.1186/s12879-024-09884-y.

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A Systematic Review on Human Monkeypox Virus Disease and Infection in Pregnancy

Cited by 3 publications

References 45 publications

A new compartmentalized epidemic model to analytically study the impact of awareness on the control and mitigation of the monkeypox disease

A new compartmentalized epidemic model to analytically study the impact of awareness on the control and mitigation of the monkeypox disease

From Outbreaks to Artificial Intelligence: A Comprehensive Review of Monkeypox Virus Epidemiology, Diagnosis, Treatment, Vaccination, and Deep Learning Applications

Multi-organ clinical manifestations of Mpox: an umbrella review of systematic reviews

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