A systematic review on improving the biocompatibility of titanium implants using nanoparticles

Nhlapo, Nthabiseng; Dzogbewu, Thywill Cephas; Smidt, Olga de

doi:10.1051/mfreview/2020030

Cited by 6 publications

(7 citation statements)

References 38 publications

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“…These industries require a specific surface quality for a specific application. For example, in the biomedical industry implanted medical devices are in direct contact with the host tissues [2,63]. The surface quality of the implanted devices (dental implants, knee implants, hip implants etc.)…”

Section: Surface Quality Of the Ti10mo Alloy Matrix Layersmentioning

confidence: 99%

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In situ alloying of Ti10Mo fused tracks and layers via laser powder bed fusion

Dzogbewu

Preez

2022

Manufacturing Rev.

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Optimum process parameters for manufacturing a Ti10Mo alloy for biomedical applications via the laser powder bed fusion (LPBF) process were determined. Fused tracks were produced over a wide range of laser powers and scanning speeds, and layers were fused at varied hatch distances. The samples were analysed for continuity of the fused tracks, melting and distribution of the Mo powder particles in the Ti10Mo alloy layers, surface roughness, homogeneity of Mo in the alloy matrix and microhardness. The analysis revealed that the Mo powder particles melted completely in the alloy matrix with only pockets of Mo concentrations, mostly at the peripheries of the fused tracks due to the pushing effect. Complete melting of Mo in the Ti10Mo alloy matrix was due to the small size (1 μm) of the Mo powder particles used in the current experiment. The addition of Mo enhanced the wetting of the powder bed and prevented a pronounced balling effect. From this study, the parameter sets 150 W, 0.5 m/s and 200 W, 1.0 m/s both at a hatch distance of 80 μm, were obtained as the optimum process parameters. However, the Mo concentrations at the peripheries of the molten pool indicated that further research was required before a ‘completely’ homogenous sample could be manufactured via the LPBF process using elemental powder blends.

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Section: Surface Quality Of the Ti10mo Alloy Matrix Layersmentioning

confidence: 99%

“…influences the bone anchoring process. Therefore, a specific high-quality surface finish is required to ensure an effective healing process [2,63].…”

Section: Surface Quality Of the Ti10mo Alloy Matrix Layersmentioning

confidence: 99%

In situ alloying of Ti10Mo fused tracks and layers via laser powder bed fusion

Dzogbewu

Preez

2022

Manufacturing Rev.

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“…Indeed, manufacturing or texturing the surface of LPBF-manufactured products at the nanoscale has a long way to go. Apart from the technical issues regarding the LPBF machines' limitations to manufacture or texture the surfaces of LPBF biomedical products at the nanoscale to prevent infections and enhance osseointegration, issues of environmental stability, health and safety also present challenges in the processing of the nanopowders, as well as the use and disposal of the nano manufactured products [84][85][86][87].…”

Section: Effect Of Surface Texture On Microorganismsmentioning

confidence: 99%

Additive Manufacturing of Titanium-Based Implants with Metal-Based Antimicrobial Agents

Dzogbewu

Preez

2021

Metals

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Due to increasing bacterial resistance to antibiotics, surface coatings of medical devices with antimicrobial agents have come to the fore. These surface coatings on medical devices were basically thin coatings that delaminated from the medical devices due to the fluid environment and the biomechanical activities associated with in-service implants. The conventional methods of manufacturing have been used to alloy metal-based antimicrobial (MBA) agents such as Cu with Ti6Al4V to enhance its antibacterial properties but failed to produce intricate shapes. Additive manufacturing technology, such as laser powder bed fusion (LPBF), could be used to produce the Ti6Al4V–xCu alloy with intricate shapes to enhance osseointegration, but have not been successful for texturing the surfaces of the Ti6Al4V–xCu samples at the nanoscale.

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“…Different biomaterials, such as titanium dioxide, tricalcium phosphate (TCP), bioactive glasses, calcium silicate, hydroxyapatite, polycaprolactone, glassy carbon, zirconia, composites with carbon nanotubes, and other metallic and ceramic materials are used in implants for bone tissue [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Titanium is a bioinert metal with good biostability, biocompatibility and long-term durability [ 6 ]. At the same time, the organic fluids can lead to the dissolving of the titanium and forming ions that can react with body tissues and appear as a toxic response [ 7 , 8 , 9 , 10 ]. Zirconium can be degraded, can have corrosion and also has poor fracture toughness similar to other metals [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Young’s Modulus and Vickers Hardness of the Hydroxyapatite Bioceramics with a Small Amount of the Multi-Walled Carbon Nanotubes

et al. 2022

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The Vickers hardness and Young’s modulus of the hydroxyapatite (HA) bioceramics with a small amount of the multi-walled carbon nanotubes (MWCNTs) were studied by using ultramicrotester Shimadzu for dynamic tests DUH-211. Small concentrations of MWCNTs were from 0.05 to 0.5 wt.%. The argon inert atmosphere and vacuum condition were taken for the prevention of the MWCNTs oxidation. The Brunauer–Emmett–Teller (BET) surface area SBET of the HA-MWCNTs composites was determined by thermal adsorption-desorption of nitrogen. It was found that for HA-MWCNTs sintered in the Ar atmosphere, an increase in the concentration of nanotubes up to 0.5 wt.% leads to a decrease in porosity near 3 times in comparison to HA without MWCNTs additives. The small amount of additives of multi-walled carbon nanotubes leads to an increase in hardness of 1.3 times and compression strength of composite and compression strength of composite that is comparable in absolute values with the literature data of enamel hardness (3–5 GPa) and compression strength (95–370 MPa). The absolute values increase close to linearly with the increase of nanotube concentrations. The Young’s modulus of sintered composite slightly changes with the variation of concentrations of nanotubes and close to the enamel (75–100 GPa). The ratio of plastic work to total work and the ratio of elastic (reversible) work to the total work of deformation of composite HA/MWCNTs are practically constant at a studied range of MWCNTs concentration. The additives of the multi-walled carbon nanotubes lead to both an increase in the elasticity index of ~1.5 times and an increase in the resistance to plastic deformation of ~3 times, which improved the tribological performance of the surface. Plastic and elastic (reversible) work slightly changed.

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A systematic review on improving the biocompatibility of titanium implants using nanoparticles

Cited by 6 publications

References 38 publications

In situ alloying of Ti10Mo fused tracks and layers via laser powder bed fusion

In situ alloying of Ti10Mo fused tracks and layers via laser powder bed fusion

Additive Manufacturing of Titanium-Based Implants with Metal-Based Antimicrobial Agents

Young’s Modulus and Vickers Hardness of the Hydroxyapatite Bioceramics with a Small Amount of the Multi-Walled Carbon Nanotubes

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