A systematic review on rapid antigen test devices for SARS-CoV-2 in nursing homes: Useful, but handle with care

Riccò, Matteo

doi:10.1016/j.eimc.2022.02.012

Cited by 2 publications

(3 citation statements)

References 9 publications

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“…For one, as suggested by calculation of sROC curves, and consistently with our current understanding of SARS-CoV-2 diagnostic options, EBC appeared particularly vulnerable to a threshold effect [ 27 ]. In other words, similarly to rapid antigen testing assays, whose reliability may be disputed for replicatory activity above the RT-qPCR equivalent of 25 to 30 cycle threshold [ 34 , 35 , 36 , 37 ], our data hints towards a scarce trustworthiness of EBC in cases of reduced availability of viral RNA. In turn, the potential shortcoming might be explained through specificities of collecting devices, strategies, and sampled patients.…”

Section: Discussionmentioning

confidence: 71%

“…In fact, such estimates were in line with earlier reports suggesting the alternative and innovative diagnostic procedures (e.g., Highly Sensitive High Performance Liquid Chromatography Laser Induced Fluorescence, photoacoustic spectroscopy and e-Nose) may represent a more rational choice to be coupled with EBC [ 5 , 6 ]. Nevertheless, diagnostic performances were substantially in line with those guaranteed by rapid antigenic testing [ 35 , 36 , 37 ], whose costs in terms of infrastructural, human and monetary resources are hardly comparable with the requests of EBC collection [ 2 , 20 , 38 ]. Moreover, application of Fagan’s nomogram [ 39 ] in order to cope with requirements of real-world settings hinted towards a further loss of diagnostic performances facing a lower circulation of the pathogen in the reference population.…”

Section: Discussionmentioning

confidence: 99%

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Potential Use of Exhaled Breath Condensate for Diagnosis of SARS-CoV-2 Infections: A Systematic Review and Meta-Analysis

et al. 2022

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Background. Reverse-transcriptase polymerase chain reaction (RT-qPCR) assays performed on respiratory samples collected through nasal swabs still represent the gold standard for COVID-19 diagnosis. Alternative methods to this invasive and time-consuming options are still being inquired, including the collection of airways lining fluids through exhaled breath condensate (EBC). Materials and Methods. We performed a systematic review and meta-analysis in order to explore the reliability of EBC as a way to collect respiratory specimens for RT-qPCR for diagnosis of COVID-19. Results. A total of 4 studies (205 specimens), were ultimately collected, with a pooled sensitivity of 69.5% (95%CI 26.8–93.4), and a pooled specificity of 98.3% (95%CI 87.8–99.8), associated with high heterogeneity and scarce diagnostic agreement with the gold standard represented by nasal swabs (Cohen’s kappa = 0.585). Discussion. Even though non-invasive options for diagnosis of COVID-19 are still necessary, EBC-based RT-qPCR showed scarce diagnostic performances, ultimately impairing its implementation in real-world settings. However, as few studies have been carried out to date, and the studies included in the present review are characterized by low numbers and low sample power, further research are requested to fully characterize the actual reliability of EBC-based RT-qPCR in the diagnosis of COVID-19.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Potential Use of Exhaled Breath Condensate for Diagnosis of SARS-CoV-2 Infections: A Systematic Review and Meta-Analysis

et al. 2022

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“…Several distinctive diagnostic procedures have been designed [ 15 , 20 , 21 , 40 , 43 , 48 , 50 , 54 , 70 ], and commercial kits have even been made available [ 49 ], with each one characterized by substantial advantages and disadvantages. As recently stressed by SARS-CoV-2 pandemic [ 82 , 83 , 84 ], RT-qPCR could radically improve the detection and the quantification of viral diseases in infected individuals, but its use in daily practice on BoDV-1 infections is limited [ 3 , 12 , 13 , 21 , 44 ]. In fact, RT-qPCR is a standard technique in post-mortem analysis for suspected BoDV-1 infections.…”

Section: Discussionmentioning

confidence: 99%

BoDV-1 Infection in Children and Adolescents: A Systematic Review and Meta-Analysis

Riccò,

Zanella,

Satta

et al. 2023

Pediatric Reports

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Borna disease virus 1 (BoDV-1) can cause a severe human syndrome characterized by meningo-myeloencephalitis. The actual epidemiology of BoDV-1 remains disputed, and our study summarized prevalence data among children and adolescents (<18-year-old). Through systematic research on three databases (PubMed, EMBASE, MedRxiv), all studies, including seroprevalence rates for BoDV-1 antigens and specific antibodies, were retrieved, and their results were summarized. We identified a total of six studies for a total of 2692 subjects aged less than 18 years (351 subjects sampled for BoDV-1 antibodies and 2557 for antigens). A pooled seroprevalence of 6.09% (95% Confidence Interval [95% CI] 2.14 to 16.17) was eventually calculated for BoDV-1 targeting antibodies and 0.76% (95% CI 0.26 to 2.19) for BoDV-1 antigens. Both estimates were affected by substantial heterogeneity. Seroprevalence rates for BoDV-1 in children and adolescents suggested that a substantial circulation of the pathogen does occur, and as infants and adolescents have relatively scarce opportunities for being exposed to hosts and animal reservoirs, the potential role of unknown vectors cannot be ruled out.

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A systematic review on rapid antigen test devices for SARS-CoV-2 in nursing homes: Useful, but handle with care

Cited by 2 publications

References 9 publications

Potential Use of Exhaled Breath Condensate for Diagnosis of SARS-CoV-2 Infections: A Systematic Review and Meta-Analysis

Potential Use of Exhaled Breath Condensate for Diagnosis of SARS-CoV-2 Infections: A Systematic Review and Meta-Analysis

BoDV-1 Infection in Children and Adolescents: A Systematic Review and Meta-Analysis

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