A systematic review on sinonasal mixed adenoneuroendocrine carcinoma

Issa, Khalil; Smith, Blaine D.; Kaplan, Samantha; Madden, John M.; Jang, David W.; Zomorodi, Ali R.; Brizel, D.M.; Hachem, Ralph Abi

doi:10.1002/alr.22811

Cited by 1 publication

(2 citation statements)

References 12 publications

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“…Moreover, several reports have described ITAC mixed with neuroendocrine carcinoma (SNEC). [29][30][31] ITAC has also been described as a recurrence of undifferentiated carcinoma (SNUC) or premalignant inverted papilloma. 32,33 Both elevated time to recurrence and changes in histology raise the question if there are recurrences that may in fact be second primary tumors.…”

Section: Discussionmentioning

confidence: 99%

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Next‐generation sequencing reveals remarkable genetic stability in primary and corresponding recurrent intestinal‐type sinonasal adenocarcinoma

Riobello,

Sánchez‐Fernández,

Córdoba

et al. 2024

Head & Neck

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BackgroundRecurrent intestinal‐type sinonasal adenocarcinoma (ITAC) can occur several years after primary treatment and with different histology. We aimed to clarify if such recurrences could be second primary tumors and to identify actionable mutations as targets for personalized treatment of recurrent ITAC.MethodsTwelve pairs of primary and recurrent ITAC were histologically examined and analyzed by next‐generation sequencing.ResultsHistological differences between primary and recurrent tumor pairs were observed in five cases. Frequent mutations included TP53, APC, TSC2, ATM, EPHA2, BRCA2, LRP1B, KRAS, and KMT2B. There was 86% concordance of somatic mutations between the tumor pairs, while four cases carried additional mutations in the recurrence.ConclusionsWe found all cases to be clonal recurrences and not second primary tumors. Moreover, tumor pairs showed a remarkable genomic stability, suggesting that personalized treatment of a recurrence may be based on actionable molecular genetic targets observed in the primary tumor.

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Section: Discussionmentioning

confidence: 99%

“…Another clinical feature of ITAC is the frequent mixture of its four histological subtypes. Moreover, several reports have described ITAC mixed with neuroendocrine carcinoma (SNEC) 29–31 . ITAC has also been described as a recurrence of undifferentiated carcinoma (SNUC) or premalignant inverted papilloma 32,33 …”

Section: Discussionmentioning

confidence: 99%