A Systematic Review on the Research Progress on Polysaccharides from Fungal Traditional Chinese Medicine

Bai, Chenxi; Su, Fazhi; Zhang, Wensen; Kuang, Haixue

doi:10.3390/molecules28196816

Cited by 5 publications

(2 citation statements)

References 137 publications

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“…In recent years, studies have shown that the extracts of medicinal plant active ingredients, including Chinese herbal polysaccharides, have been playing a positive role in livestock production and disease prevention and treatment (12). Chinese herbal polysaccharide can play a variety of biological functions (36,37), such as antiinflammatory (38), anti-tumor (39), antioxidant, lowering blood sugar, lowering blood lipids (40), immune regulation (41), and regulating intestinal flora (42), etc. Chen et al found that the basal diet supplemented with 1,000 mg/kg Lonicera fulvotomentosa extract could significantly increase the final weight of weaned piglets and the diversity and richness of intestinal flora in the jejunum and rectum.…”

Section: Discussionmentioning

confidence: 99%

Yupingfeng polysaccharide promote the growth of chickens via regulating gut microbiota

Guan,

Zheng,

Bai

et al. 2024

Front. Vet. Sci.

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IntroductionYupingfeng polysaccharide (YPF-P) is the main substance of alcohol deposition in Yupingfeng powder, which has many biological functions such as enhancing immunity, repairing intestinal barrier and enhancing antioxidant ability. This study employed in vitro growth-promoting drug feed additives and animal experiments to comprehensively evaluate the use of YPF-P in broiler production.MethodsA total of 1,296 151 days-old Qingyuan Partridge chickens were randomly divided into four groups with six replicates and 54 hens per replicate: the control group was fed basal diet, and the experimental groups were fed diets supplemented with 4 g/kg, 8 g/kg, and 12 g/kg YPF-P for 14 days. Broilers were weighed before and at the end of the experiment to calculate total weight gain (GW), average daily gain (ADG), and feed compensation. At the end of the experiment, six chickens from each group were randomly selected for subwing vein blood sampling, which was used to measure serum biochemical indicators GHRH, GH, and IGF-1 by ELISA method. Randomly select chickens from control group and 8 g/kg group for slaughter, and cecal contents were collected for 16S high-throughput sequencing.ResultsDietary supplementation of 8 g/kg YPF-P can significantly increase the final body weight, total weight gain, average daily gain and decrease the feed to gain ratio of chickens. During 151–165 days, serum IGF-1 concentrations increased significantly (p < 0.05). There were no significant changes in serum GH concentration (p > 0.05). In terms of gut microbiota, there was no significant difference between control group and test group in Shannon index and Simpson index. Compared with the control group,the addition of 8 g/kgYPF-P significantly increased the abundance of Firmicutes and significantly decreased the abundance of Bacteroides at the phylum level.At the genus level, the relative abundance of unclassified_Oscillospiraceae was significantly increased and the unclassified_Muribaculaceae, uncultured_Bacteroidales_bacterium, Lactobacillus, Alloprevotella, Ligilactobacillus, Prevotellaceae_UCG_001, and unclassified_Atopobiaceae was significantly decreased.ConclusionThe above results showed that adding 8 mg/kg of YPF-P could increase the average daily gain of Qingyuan Partridge chickens, reduce the ratio of feed to meat, and affect the distribution proportion of intestinal microflora in chickens to some extent.

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Section: Discussionmentioning

confidence: 99%

Yupingfeng polysaccharide promote the growth of chickens via regulating gut microbiota

Guan,

Zheng,

Bai

et al. 2024

Front. Vet. Sci.

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“…Adaptogens are substances that help the body adapt to stressors and enhance their performance [16][17][18] by promoting balance and resilience without causing significant side effects. Fungi, like Ganoderma lucidum (Lingzhi), Cordyceps sinensis (Dong Chong Xia Cao), Lentinula edodes (Shiitake), Auricularia auricula-judae (Wood Ear), Trametes versicolor (Yunzhi), and Tremella fuciformis (Silver Ear), with their high contents of bioactive compounds, such as polysaccharides [19], triterpenoids [20], flavonoids and phenolic compounds [21], have been utilized in TCM for centuries to bolster the body's defenses, enhance vitality, and restore equilibrium, with beneficial effects on the aging process by supporting longevity and vitality [22,23].…”

Section: Introductionmentioning

confidence: 99%

NAD-Driven Sirtuin Activation by Cordyceps sinensis Extract: Exploring the Adaptogenic Potential to Promote Skin Longevity

Di Lorenzo,

Falanga,

Ricci

et al. 2024

IJMS

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In recent years, there has been increasing interest in utilizing Traditional Chinese Medicine principles and natural bioactive compounds to combat age-related ailments and enhance longevity. A Cordyceps sinensis mycelium hydroethanolic extract (CsEx), which was standardized in cordycepin and adenosine using UHPLC-DAD, was investigated for its adaptogenic properties using in vitro assays and a double-blind, placebo-controlled clinical trial involving 40 subjects. The CsEx demonstrated activity at a concentration of 0.0006%, significantly increasing sirtuin expression (SirT1: +33%, SirT3: +10%, SirT6: +72%, vs. CTR, p < 0.05) and NAD+ synthesis in HaCat cells (+20% vs. CTR, p < 0.001). Moreover, the CsEx boosted ATP production by 68% in skin cells, correlating with higher skin energy values (+52.0% at D28, p < 0.01) in the clinical trial. Additionally, CsEx notably reduced cytosolic reactive oxygen species (ROS) by 30% in HaCaT cells (p < 0.05) and enhanced collagen production both in vitro (+69% vs. CTR, p < 0.01) and in vivo (+10% vs. D0, p < 0.01), confirmed by ultrasound examination. Furthermore, CsEx’s stimulation of fibroblasts, coupled with its antioxidant and energizing properties, led to a significant reduction in wrinkles by 28.0% (D28, p < 0.001). This study underscores Cordyceps sinensis hydroethanolic extract’s potential in regulating skin cell energy metabolism and positively influencing the mechanisms associated with skin longevity control.

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α-Amylase inhibition and antioxidative activities of Marasmius tax sp extract: A combined in vitro and in silico exploration

Raju,

Saju,

Jenny

et al. 2024

Pharmacological Research - Natural Products

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A Systematic Review on the Research Progress on Polysaccharides from Fungal Traditional Chinese Medicine

Cited by 5 publications

References 137 publications

Yupingfeng polysaccharide promote the growth of chickens via regulating gut microbiota

Yupingfeng polysaccharide promote the growth of chickens via regulating gut microbiota

NAD-Driven Sirtuin Activation by Cordyceps sinensis Extract: Exploring the Adaptogenic Potential to Promote Skin Longevity

α-Amylase inhibition and antioxidative activities of Marasmius tax sp extract: A combined in vitro and in silico exploration

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