A Systematic Review on the Effectiveness of Enteral Immunonutrition (EIN) on Pre- and Post-Operative Outcomes in Gastric Cancer Patients

Yanok, Ruth Merry Paranjothi; Sa’id, Iklil Iman Mohd; Chau, Shin Hwa; Kai, Yee Seng; Safii, Nik Shanita; Yap, Wei Boon

doi:10.17576/jsm-2020-4903-17

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Also, additional studies are required to provide a clinically meaningful difference in the outcomes. This was also suggested in a previous similar meta‐analysis study, which showed a similar effect of enteral immunonutrition and enteral nutrition in subjects with gastric cancer undergoing a total gastrectomy 30‐36 . The insignificant result between enteral immunonutrition and enteral nutrition in some of the studied outcomes also needs additional study and clarification because no clear reasoning was found to clarify these outcomes.…”

Section: Discussionmentioning

confidence: 56%

“…This was also suggested in a previous similar meta‐analysis study, which showed a similar effect of enteral immunonutrition and enteral nutrition in subjects with gastric cancer undergoing a total gastrectomy. 30 , 31 , 32 , 33 , 34 , 35 , 36 The insignificant result between enteral immunonutrition and enteral nutrition in some of the studied outcomes also needs additional study and clarification because no clear reasoning was found to clarify these outcomes. Well‐conducted studies are also required to measure these factors and the blend of different gender, ages, and ethnicity, because our meta‐analysis study could not answer whether they are related to the outcomes.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of enteral immunonutrition compared with enteral nutrition on surgical wound infection, immune and inflammatory factors, serum proteins, and cellular immunity in subjects with gastric cancer undergoing a total gastrectomy: A meta‐analysis

Fu¹,

Li²,

Liang³

2022

International Wound Journal

View full text Add to dashboard Cite

We performed a meta‐analysis to evaluate the effect of enteral immunonutrition compared with enteral nutrition on surgical wound infection, immune and inflammatory factors, serum proteins, and cellular immunity in subjects with gastric cancer undergoing a total gastrectomy. A systematic literature search up to November 2021 was done, and 10 studies included 1056 subjects with gastric cancer undergoing a total gastrectomy at the start of the study: 505 of them were provided with enteral immunonutrition, and 551 were enteral nutrition. They were reporting relationships about the effect of enteral immunonutrition compared with enteral nutrition on surgical wound infection, immune and inflammatory factors, serum proteins, and cellular immunity in subjects with gastric cancer undergoing a total gastrectomy. We calculated the odds ratio (OR) or mean difference (MD) with 95% confidence intervals (CIs) to assess the effect of enteral immunonutrition compared with enteral nutrition on surgical wound infection, immune and inflammatory factors, serum proteins, and cellular immunity in subjects with gastric cancer undergoing a total gastrectomy using the dichotomous or contentious method with a random or fixed‐effect model. Enteral immunonutrition had no significant difference in the surgical wound infection (OR, 0.77; 95% CI, 0.50‐1.19, P = .24), the infectious complication (OR, 0.72; 95% CI, .48‐1.09, P = .13), the systemic inflammatory response syndrome (MD, ‐0.50; 95% CI, −1.40 to 0.39, P = .27), the CD8+ level (MD, 1.34; 95% CI, 0‐2.68, P = .05), the CD4+ level (MD, 1.21; 95% CI, −7.65 to 10.07, P = .79), the CD4‐CD8+ (MD, 0.55; 95% CI, 0‐1.10, P = .05), the lymphocyte (MD, −0.77; 95% CI, −1.87 to 0.33, P = .17), and the transferrin (MD, 0.03; 95% CI, −0.01 to 0.08, P = .14) compared with enteral nutrition in subjects with gastric cancer undergoing a total gastrectomy. However, enteral immunonutrition had significantly higher proalbumin (MD, 22.15; 95% CI, 3.57‐40.72, P = .02), IgM (MD, 0.47; 95% CI, 0.43‐0.50, P < .001), and IgG (MD, 1.98; 95% CI, 1.08‐2.89, P < .001) compared with enteral nutrition in subjects with gastric cancer undergoing a total gastrectomy. Enteral immunonutrition had no significant difference in the surgical wound infection, the infectious complication, the systemic inflammatory response syndrome, the CD8+ level, the CD4+ level, the CD4+/CD8+, the lymphocyte, and the transferrin, and had significantly higher proalbumin, IgM, and IgG compared with enteral nutrition in subjects with gastric cancer undergoing a total gastrectomy. Further studies are required to validate these findings or to affect the confidence level.

show abstract

Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Effect of enteral immunonutrition compared with enteral nutrition on surgical wound infection, immune and inflammatory factors, serum proteins, and cellular immunity in subjects with gastric cancer undergoing a total gastrectomy: A meta‐analysis

Fu¹,

Li²,

Liang³

2022

International Wound Journal

View full text Add to dashboard Cite

show abstract

“…conformada por nueve artículos de tipo ECA, siete de ellos sobre el tratamiento post operatorio con inmunonutrición enteral y los otros dos artículos sobre el tratamiento pre quirúrgico con inmunonutrición oral. La terapia con arginina, glutamina, omega-3 y nucleótidos, tanto pre y post quirúrgico, redujo la incidencia de complicaciones infecciosas y la estancia hospitalaria (100).…”

Section: Hallazgosunclassified

Efecto de la inmunonutrición enteral como estrategia nutricional en pacientes oncológicos hospitalizados sometidos a cirugías mayores gastrointestinales: Revisión sistemática y metaanálisis

Recoba Obregon

View full text Add to dashboard Cite

El paciente oncológico con tratamiento quirúrgico gástrico o de colon con desnutrición, pueden presentar alteraciones con respeto a la respuesta inflamatoria y complicaciones post operatorias. El objetivo de este estudio fue evaluar, a partir de una revisión sistemática con metaanálisis, el efecto de la inmunonutrición enteral (arginina, glutamina, omega 3 y nucleótidos) como estrategia nutricional en pacientes oncológicos hospitalizados sometidos a cirugías mayores gastrointestinales para la disminuir las complicaciones post operatorias y modificar los cambios en la respuesta inflamatoria. Se revisó la literatura tanto en español, inglés y portugués para recolectar la información registrada en las bases de datos Medline a través de Ovid, Cochrane (Central), Scopus, Web of Science y EMBASE. Adicionalmente se realizó la búsqueda en los motores como Google Académico y Trip Data Base. Se detectaron 1236 artículos relacionados al tema, de los cuales se seleccionaron 18 ensayos clínicos aleatorizados (ECA) internacionales (5,5 % desarrollados en América, 50 % en Asia y 44,5 % en Europa). Esta selección se basó en los criterios de inclusión-exclusión, y mediante la metodología de la herramienta Cochrane, para la clasificación de la calidad de la evidencia en la tabla de resumen y graduación de la fuerza de recomendación se utilizó el sistema GRADE. Por lo tanto, los criterios de selección de la literatura para este estudio, permitieron identificar un nivel de certeza baja y fuerza de recomendación fuerte para los resultados de complicaciones post operatorias por infecciones (RR 0.74 IC 95%; 0.60-0.90, p=0.003; I2=12%) para el tratamiento con inmunonutrición enteral, aplicada a pacientes con cáncer gástrico y colon. Este resultado avala el efecto favorable de la inmunonutrición enteral en el manejo de las complicaciones post operatorias infecciosas en el paciente oncológico con cirugías mayores gastrointestinales.

show abstract

A Systematic Review on the Effectiveness of Enteral Immunonutrition (EIN) on Pre- and Post-Operative Outcomes in Gastric Cancer Patients

Cited by 2 publications

References 0 publications

Effect of enteral immunonutrition compared with enteral nutrition on surgical wound infection, immune and inflammatory factors, serum proteins, and cellular immunity in subjects with gastric cancer undergoing a total gastrectomy: A meta‐analysis

Effect of enteral immunonutrition compared with enteral nutrition on surgical wound infection, immune and inflammatory factors, serum proteins, and cellular immunity in subjects with gastric cancer undergoing a total gastrectomy: A meta‐analysis

Efecto de la inmunonutrición enteral como estrategia nutricional en pacientes oncológicos hospitalizados sometidos a cirugías mayores gastrointestinales: Revisión sistemática y metaanálisis

Contact Info

Product

Resources

About