A Systematic Review on Traditional Uses, Sources, Phytochemistry, Pharmacology, Pharmacokinetics, and Toxicity of Fritillariae Cirrhosae Bulbus

Chen, Ting; Zhong, Furong; Yao, Cheng; Chen, Jia; Xiang, Yiqing; Dong, Jijing; Yan, Zhuyun; Ma, Yuntong

doi:10.1155/2020/1536534

Cited by 42 publications

(23 citation statements)

References 89 publications

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“…This plant has biological activities such as antitussive, expectorant, analgesic, anticancer, anti-inflammatory, and antioxidative. Moreover, this plant has therapeutic effects on many diseases such as cancer, acute lung injury, chronic obstructive, pulmonary diseases, asthma, Parkinson’s disease, and diabetes [ 34 ]. Thus, we assume that it has potential as natural antibiotic for its anti-inflammatory attribute.…”

Section: Resultsmentioning

confidence: 99%

Prediction of Potential Natural Antibiotics Plants Based on Jamu Formula Using Random Forest Classifier

et al. 2022

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Jamu is the traditional Indonesian herbal medicine system that is considered to have many benefits such as serving as a cure for diseases or maintaining sound health. A Jamu medicine is generally made from a mixture of several herbs. Natural antibiotics can provide a way to handle the problem of antibiotic resistance. This research aims to discover the potential of herbal plants as natural antibiotic candidates based on a machine learning approach. Our input data consists of a list of herbal formulas with plants as their constituents. The target class corresponds to bacterial diseases that can be cured by herbal formulas. The best model has been observed by implementing the Random Forest (RF) algorithm. For 10-fold cross-validations, the maximum accuracy, recall, and precision are 91.10%, 91.10%, and 90.54% with standard deviations 1.05, 1.05, and 1.48, respectively, which imply that the model obtained is good and robust. This study has shown that 14 plants can be potentially used as natural antibiotic candidates. Furthermore, according to scientific journals, 10 of the 14 selected plants have direct or indirect antibacterial activity.

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Section: Resultsmentioning

confidence: 99%

Prediction of Potential Natural Antibiotics Plants Based on Jamu Formula Using Random Forest Classifier

et al. 2022

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“…regulate cholesterol-lowering activities ( Nyakudya et al, 2014 ). Bei-Mu (BM; Fritillaria cirrhosa D.Don; family Liliaceae) exhibits analgesic, antioxidative, and anti-inflammatory effects ( Chen T. et al, 2020 ). Yu-Xing-Cao (YXC; Houttuynia cordata Thunb.…”

Section: Discussionmentioning

confidence: 99%

Effect of Chinese Herbal Medicine Therapy on Risks of Overall, Diabetes-Related, and Cardiovascular Diseases-Related Mortalities in Taiwanese Patients With Hereditary Hemolytic Anemias

et al. 2022

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Hereditary Hemolytic Anemias (HHAs) are a rare but heterogeneous group of erythrocytic diseases, characterized by intrinsic cellular defects due to inherited genetic mutations. We investigated the efficacy of Chinese herbal medicine (CHM) in reducing the overall, diabetes-related, and cardiovascular diseases (CVDs)-related mortalities among patients with HHAs using a nationwide population database. In total, we identified 33,278 patients with HHAs and included 9,222 non-CHM and 9,222 CHM matched pairs after matching. The Cox proportional hazards model was used to compare the risk of mortality between non-CHM and CHM users. The Kaplan-Meier method and log-rank test were used to compare the cumulative incidence mortality between non-CHM and CHM users. The CHM prescription patterns were presented by the association rules and network analyses, respectively. The CHM prescription patterns were presented by the association rules and network analyses, respectively. CHM users showed significant reduced risks for of overall (adjusted hazard ratio [aHR]: 0.67, 95% confidence interval [CI]: 0.61–0.73, p < 0.001), diabetes-related (aHR: 0.57, 95% CI: 0.40–0.82, p < 0.001), and CVDs-related (aHR: 0.59, 95% CI: 0.49–0.72, p < 0.001) mortalities compared with non-CHM users. Two CHM clusters are frequently used to treat Taiwanese patients with HHAs. Cluster 1 is composed of six CHMs: Bei-Mu (BM; Fritillaria cirrhosa D.Don), Gan-Cao (GC; Glycyrrhiza uralensis Fisch.), Hai-Piao-Xiao (HPX; Endoconcha Sepiae), Jie-Geng (JG; Platycodon grandiflorus (Jacq.) A.DC.), Yu-Xing-Cao (YXC; Houttuynia cordata Thunb.), and Xin-Yi-Qing-Fei-Tang (XYQFT). Cluster 2 is composed of two CHMs, Dang-Gui (DG; Angelica sinensis (Oliv.) Diels) and Huang-Qi (HQi; Astragalus membranaceus (Fisch.) Bunge). Further randomized clinical trials are essential to evaluate the safety and effectiveness of above CHM products and to eliminate potential biases in the current retrospective study.

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“…Bokhari ( Bokhari and Syed, 2015 ) found that BFC could significantly suppress TGF-β/SMAD signaling pathway to inhibit cancer cell proliferation, invasion, and metastasis. What’s more, studies showed that BFC exerted a potent therapeutic effect on lung cancer ( Wang et al, 2014b ; Chen et al, 2020d ). Li suggested that BFC was the most commonly used single herb for the treatment of lung cancer ( Li et al, 2018 ).…”

Section: The Mechanisms Of Bfc In the Treatment Of Lung Cancermentioning

confidence: 99%

Bulbus Fritillariae Cirrhosae as a Respiratory Medicine: Is There a Potential Drug in the Treatment of COVID-19?

Quan

Yin

et al. 2022

Front. Pharmacol.

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Bulbus fritillariae cirrhosae (BFC) is one of the most used Chinese medicines for lung disease, and exerts antitussive, expectorant, anti-inflammatory, anti-asthmatic, and antioxidant effects, which is an ideal therapeutic drug for respiratory diseases such as ARDS, COPD, asthma, lung cancer, and pulmonary tuberculosis. Through this review, it is found that the therapeutic mechanism of BFC on respiratory diseases exhibits the characteristics of multi-components, multi-targets, and multi-signaling pathways. In particular, the therapeutic potential of BFC in terms of intervention of “cytokine storm”, STAT, NF-κB, and MAPK signaling pathways, as well as the renin-angiotensin system (RAS) that ACE is involved in. In the “cytokine storm” of SARS-CoV-2 infection there is an intense inflammatory response. ACE2 regulates the RAS by degradation of Ang II produced by ACE, which is associated with SARS-CoV-2. For COVID-19, may it be a potential drug? This review summarized the research progress of BFC in the respiratory diseases, discussed the development potentiality of BFC for the treatment of COVID-19, explained the chemical diversity and biological significance of the alkaloids in BFC, and clarified the material basis, molecular targets, and signaling pathways of BFC for the respiratory diseases. We hope this review can provide insights on the drug discovery of anti-COVID-19.

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A Systematic Review on Traditional Uses, Sources, Phytochemistry, Pharmacology, Pharmacokinetics, and Toxicity of Fritillariae Cirrhosae Bulbus

Cited by 42 publications

References 89 publications

Prediction of Potential Natural Antibiotics Plants Based on Jamu Formula Using Random Forest Classifier

Prediction of Potential Natural Antibiotics Plants Based on Jamu Formula Using Random Forest Classifier

Effect of Chinese Herbal Medicine Therapy on Risks of Overall, Diabetes-Related, and Cardiovascular Diseases-Related Mortalities in Taiwanese Patients With Hereditary Hemolytic Anemias

Bulbus Fritillariae Cirrhosae as a Respiratory Medicine: Is There a Potential Drug in the Treatment of COVID-19?

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