A systematic review with meta-analysis to assess Alzheimer's disease biomarkers in adults with or without obstructive sleep apnoea

Mohammadi, Iman; Adibparsa, Mehrdad; Najafi, Amir; Sehat, Mohammad Soroush; Sadeghi, Masoud

doi:10.1016/j.ortho.2023.100814

Cited by 2 publications

(2 citation statements)

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“…It is produced by processing a precursor consisting of 203 amino acids. In many mammals, there are three peptide isomers encoded by different genes: ET-1, ET-2, and ET-3 (ET-1: Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bonds between Cys 1 -Cys 15 and Cys 3 -Cys 11 ), ET-2: Cys-Ser-Cys-Ser-Ser-Trp-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bonds between Cys 1 -Cys 15 and Cys 3 -Cys 11 ), ET-3: Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bonds between Cys 1 -Cys 15 and Cys 3 -Cys 11 ) in human endothelins). Endothelin has a transient vasodilatory effect followed by a sustained vasoconstrictive effect.…”

Section: Endothelin 1 (Et-1)mentioning

confidence: 99%

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Possible Molecular Mechanisms of Hypertension Induced by Sleep Apnea Syndrome/Intermittent Hypoxia

Takeda,

Kimura,

Takasawa

2024

Life

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Intermittent hypoxia (IH) is a central characteristic of sleep apnea syndrome (SAS), and it subjects cells in the body to repetitive apnea, chronic hypoxia, oxygen desaturation, and hypercapnia. Since SAS is linked to various serious cardiovascular complications, especially hypertension, many studies have been conducted to elucidate the mechanism of hypertension induced by SAS/IH. Hypertension in SAS is associated with numerous cardiovascular disorders. As hypertension is the most common complication of SAS, cell and animal models to study SAS/IH have developed and provided lots of hints for elucidating the molecular mechanisms of hypertension induced by IH. However, the detailed mechanisms are obscure and under investigation. This review outlines the molecular mechanisms of hypertension in IH, which include the regulation systems of reactive oxygen species (ROS) that activate the renin–angiotensin system (RAS) and catecholamine biosynthesis in the sympathetic nervous system, resulting in hypertension. And hypoxia-inducible factors (HIFs), Endotheline 1 (ET-1), and inflammatory factors are also mentioned. In addition, we will discuss the influences of SAS/IH in cardiovascular dysfunction and the relationship of microRNA (miRNA)s to regulate the key molecules in each mechanism, which has become more apparent in recent years. These findings provide insight into the pathogenesis of SAS and help in the development of future treatments.

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Section: Endothelin 1 (Et-1)mentioning

confidence: 99%

“…SAS is linked to several complications and afflicts many patients. Some of those complications include obesity [2,3], type 2 diabetes [4][5][6][7], dyslipidemia [8,9], dementia [10,11], mood disorders [12], and, especially, hypertension [13][14][15].…”

Section: Introductionmentioning

confidence: 99%