2018
DOI: 10.12659/msm.908104
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A Systems Biology-Based Approach to Uncovering Molecular Mechanisms Underlying Effects of Traditional Chinese Medicine Qingdai in Chronic Myelogenous Leukemia, Involving Integration of Network Pharmacology and Molecular Docking Technology

Abstract: BackgroundThe method of multiple targets overall control is increasingly used to predict the main active ingredient and potential target group of Chinese traditional medicines and to determine the mechanisms involved in their curative effects. Qingdai is the main traditional Chinese medicine used in the treatment of chronic myelogenous leukemia (CML), but the complex active ingredients and antitumor targets in treatment of CML have not been clearly defined in previous studies.Material/MethodsWe constructed a p… Show more

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Cited by 27 publications
(20 citation statements)
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“…Certain problems such as the interaction between targets bring a level of uncertainty into the TCM system and make it unacceptable to the natives and nonnatives. erefore, it must be combined with network pharmacology to make TCM more effective [31][32][33][34]. With the development of human society and the change of surroundings, human diseases have gradually transformed from infectious diseases to chronic diseases including cardiovascular diseases, diabetes mellitus, and tumors.…”
Section: Application In Traditional Chinese Medicinementioning
confidence: 99%
“…Certain problems such as the interaction between targets bring a level of uncertainty into the TCM system and make it unacceptable to the natives and nonnatives. erefore, it must be combined with network pharmacology to make TCM more effective [31][32][33][34]. With the development of human society and the change of surroundings, human diseases have gradually transformed from infectious diseases to chronic diseases including cardiovascular diseases, diabetes mellitus, and tumors.…”
Section: Application In Traditional Chinese Medicinementioning
confidence: 99%
“…In recent years, virtual pharmacology research was regarded as the fastest and most effective screening method in the early study of drug effectiveness. 21,23,[28][29][30][31][32] Gentianella acuta is an old drug commonly used for treating hepatitis and carcinoma. Therefore, in this study, Gentiopicroside was employed to study the gastric cancer enriching mechanism by network pharmacology approach.…”
Section: Discussionmentioning
confidence: 99%
“…In particular, computational target identification and following the molecular mechanisms can accelerate the drug discovery and drug design process. [20][21][22][23] Therefore, we elucidated the pharmacological actions of Gentiopicroside on gastric cancer systematically using computational methodologies. Then, we used the molecular docking and a series of in vitro assays to validate its effects on GC.…”
Section: Introductionmentioning
confidence: 99%
“…Fortunately, network pharmacology has been proven to be a suitable method to explore the underlying mechanism between TCM and known targets systematically. Based on the interaction among active components of TCM and their protein targets, as well as relevant biological functions and pathways, a network pharmacology study enables us to investigate the possible molecular mechanisms of a TCM to a particular disease [ 12 ].…”
Section: Introductionmentioning
confidence: 99%