A T-cell receptor γ/CD3 complex found on cloned functional lymphocytes

Borst, Jannie; Griend, R J van de; Oostveen, J. W. Van; Ang, Siew‐Lan; Melief, Cornelis J.M.; Seidman, J. G.; Bolhuis, R. L. H.

doi:10.1038/325683a0

Cited by 420 publications

(184 citation statements)

References 53 publications

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“…It is now established that T lymphocytes of this subset express a TCR-y/S (35)(36)(37)(38) and are capable of performing nonrestricted (39,40) as well as MHC-linked specific cytolytic functions (41,42).…”

Section: Discussionmentioning

confidence: 99%

Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.

Jonjić

Mutter

Weiland

et al. 1989

The Journal of Experimental Medicine

521

339

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We have established a murine model system for exploring the ability of a CD4 subset-deficient host to cope with cytomegalovirus infection, and reported three findings. First, an antiviral response of the CD8 subset of T lymphocytes could be not only initiated but also maintained for a long period of time despite a continued absence of the CD4 subset, whereas the production of antiviral antibody proved strictly dependent upon help provided by the CD4 subset. Second, no function in the defense against infection could be ascribed as yet to CD4-CD8- T lymphocytes, which were seen to accumulate to a new subset as a result of depletion of the CD4 subset. This newly arising subset did not substitute for CD4+ T lymphocytes in providing help to B lymphocytes, and was also not effective in controlling the spread of virus in host tissues. As long as a function of these cells in the generation and maintenance of a CD8 subset-mediated response is not disproved, caution is indicated with concern to an autonomy of the CD8 subset. Third, even though with delay, the CD8+ effector cells raised in the CD4 subset-deficient host were able of clear vital tissues from productive infection and to restrict asymptomatic, persistent infection to acinar glandular epithelial cells in salivary gland tissue.

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Section: Discussionmentioning

confidence: 99%

Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.

Jonjić

Mutter

Weiland

et al. 1989

The Journal of Experimental Medicine

521

339

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“…CD4 or CD8 cells are characterized by their expression of the ab form of the T cell receptor whereas a minor subset (< 5% in normal human donors) bears the gd T cell receptor and is CD4 -and CD8 -but CD3 + [82,83]. This subset is markedly expanded during the first phase of TB infection in the mouse [84] and has been suggested to be involved as a first line of defence recognizing heat shock antigens [85], a 10-14 kDa antigen released from the bacilli by heat treatment [86], or low mass non-peptidic ligands on the surface of the macrophage [87].…”

Section: Host Responses and Antigens Involved In Protective Immunity mentioning

confidence: 99%

Host Responses and Antigens Involved in Protective Immunity to Mycobacterium tuberculosis

1997

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Andersen P. Host Responses and Antigens Involved in Protective Immunity to Mycobacterium tuberculosis. Scand J Immunol 1997;45:115-131 Tuberculosis (TB) is the largest single infectious cause of human mortality. The incidence of TB has remained high in most of the developing world and the disease has recently re-emerged as a public health problem in industrialized countries. The development of a new improved TB vaccine is a highly prioritized international research area, which has been further stimulated by the appearance of multi-drug resistant strains of Mycobacterium tuberculosis. The present status of the attempts to characterize the protective immune response to TB will be reviewed with special emphasis on recent progress in the identification and characterization of target molecules recognized by protective cells. This paper will focus on proteins released from live bacteria and discuss their role in the host-pathogen interaction and the ongoing attempts to use these molecules in TB subunit vaccines.

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“…In spite of these extensive investigations, tbe functions of CD4-CD8-TCRa/?+ T cells which have been reported so far are controversial. Borst et al (1987) derived a double-negative TCRa/i+ T cell clone from the peripheral blood of a healthy adult, but this elone had little cytolytic activity. In contrast, Groh et al (1989) first reported the spontaneous MHC-unrestrieted cytotoxic activity of human double-negative TCRa)5+ T eells derived from the skin.…”

Section: Discussionmentioning

confidence: 99%

Human double-negative (CD4-CD8-) T cells bearing αβ T cell receptor possess both helper and cytotoxic activities

Matsumoto

Yasukawa

Inatsuki

et al. 1991

Clinical and Experimental Immunology

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SUMMARYExpression of CD4 or CD8 on the cell surface is an important guide for discriminating tbe immunoiogical functions of T cells. However, a minor T cell subset, which lacks both CD4 and CD8 molecules but bears the usual form of T cell receptor (TCR) afi (CD4-CD8-TCRa^+ T cells), has recently been found not only in mice but also in humans, and its role in immune response is now of considerable interest. In order to clarify tbe cbaracteristies of this newly defined T eell subpopulation, we established five IL-2-dependent CD4~CD8"TCRa/S+ T cell clones from the peripheral blood of a healthy individual, and examined their various biological functions. It was found that all clones not only helped B cells in immunoglobulin production, but also exerted major histocompatibility complex-unrestricted eytotoxicity. Although their CD3/TCR complexes were functionally competent, the cytotoxicity seemed to be mediated via unknown molecules other than the CD3/TCR complex, as evidenced by the failure of CD3 MoAb to inhibit the cytotoxic activity. Our present findings showed that CD4"CD8'"TCRa^+ T eells possess potential bifunction, i.e. helper and cytotoxic activities. Their roles in the pathogenesis of immunodeficiency are discussed.

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A T-cell receptor γ/CD3 complex found on cloned functional lymphocytes

Cited by 420 publications

References 53 publications

Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.

Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.

Host Responses and Antigens Involved in Protective Immunity to Mycobacterium tuberculosis

Human double-negative (CD4-CD8-) T cells bearing αβ T cell receptor possess both helper and cytotoxic activities

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