A tale of two tinnituses: Does hearing status influence central tinnitus localization?

Naples, James G.; Sadler, Samantha; Watson, Nathan; Miller, Lauren E.; Alterman, Ron L.

doi:10.1016/j.mehy.2020.110444

Cited by 3 publications

(3 citation statements)

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“…It also negatively affects social communication ( Maharani et al, 2019 ), which may contribute to cognitive decline. The concept that hearing and cognitive functions are tightly linked and interdependent is also indicated by the fact that speech recognition outcomes of cochlear implant patients depend on the cognitive abilities of the recipient ( Akeroyd, 2008 ; Lazard et al, 2012 ; Naples et al, 2021 ). With that regard, it has been proposed that treatment of hearing loss may prevent the development of neuronal dysfunction and cognitive decline after hearing loss ( Naples et al, 2021 ; Powell et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…The concept that hearing and cognitive functions are tightly linked and interdependent is also indicated by the fact that speech recognition outcomes of cochlear implant patients depend on the cognitive abilities of the recipient ( Akeroyd, 2008 ; Lazard et al, 2012 ; Naples et al, 2021 ). With that regard, it has been proposed that treatment of hearing loss may prevent the development of neuronal dysfunction and cognitive decline after hearing loss ( Naples et al, 2021 ; Powell et al, 2021 ). Recent studies also propose that successful hearing rehabilitation, including cochlear implants, may positively affect cognitive abilities and neuropsychiatric symptoms ( Mamo et al, 2018 ; Mosnier et al, 2018 ; Kim et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Processing of auditory information in forebrain regions after hearing loss in adulthood: Behavioral and electrophysiological studies in a rat model

et al. 2022

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BackgroundHearing loss was proposed as a factor affecting development of cognitive impairment in elderly. Deficits cannot be explained primarily by dysfunctional neuronal networks within the central auditory system. We here tested the impact of hearing loss in adult rats on motor, social, and cognitive function. Furthermore, potential changes in the neuronal activity in the medial prefrontal cortex (mPFC) and the inferior colliculus (IC) were evaluated.Materials and methodsIn adult male Sprague Dawley rats hearing loss was induced under general anesthesia with intracochlear injection of neomycin. Sham-operated and naive rats served as controls. Postsurgical acoustically evoked auditory brainstem response (ABR)-measurements verified hearing loss after intracochlear neomycin-injection, respectively, intact hearing in sham-operated and naive controls. In intervals of 8 weeks and up to 12 months after surgery rats were tested for locomotor activity (open field) and coordination (Rotarod), for social interaction and preference, and for learning and memory (4-arms baited 8-arms radial maze test). In a final setting, electrophysiological recordings were performed in the mPFC and the IC.ResultsLocomotor activity did not differ between deaf and control rats, whereas motor coordination on the Rotarod was disturbed in deaf rats (P < 0.05). Learning the concept of the radial maze test was initially disturbed in deaf rats (P < 0.05), whereas retesting every 8 weeks did not show long-term memory deficits. Social interaction and preference was also not affected by hearing loss. Final electrophysiological recordings in anesthetized rats revealed reduced firing rates, enhanced irregular firing, and reduced oscillatory theta band activity (4–8 Hz) in the mPFC of deaf rats as compared to controls (P < 0.05). In the IC, reduced oscillatory theta (4–8 Hz) and gamma (30–100 Hz) band activity was found in deaf rats (P < 0.05).ConclusionMinor and transient behavioral deficits do not confirm direct impact of long-term hearing loss on cognitive function in rats. However, the altered neuronal activities in the mPFC and IC after hearing loss indicate effects on neuronal networks in and outside the central auditory system with potential consequences on cognitive function.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Processing of auditory information in forebrain regions after hearing loss in adulthood: Behavioral and electrophysiological studies in a rat model

et al. 2022

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“…Second, given the current discrepancies in the literature, this study may provide the groundwork for similar studies critically analyzing additional rTMS parameters. Studies directed at better understanding other variables possibly contributing to rTMS outcomes, such as stimulation frequency, 31 hearing status, 32 or patient duration of tinnitus, 18 may serve to be equally important for future approaches to treat chronic tinnitus.…”

Section: Discussionmentioning

confidence: 99%

Is There an Optimal Repetitive Transcranial Magnetic Stimulation Target to Treat Chronic Tinnitus?

Watson

Schaper

Jabbour

et al. 2022

Otolaryngol.--head neck surg.

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Objective Chronic tinnitus is a clinical symptom that affects 10% to 15% of the adult population. Repetitive transcranial magnetic stimulation (rTMS) is a promising treatment, but significant heterogeneity exists in the treatment outcomes and stimulation parameters. In this study, we perform a qualitative systematic review to determine if there is an optimal rTMS site to treat tinnitus. Data Sources A literature search was performed by searching the MEDLINE, Embase, Web of Science, and Cochrane databases. Review Methods Sham-controlled studies in adults were included that contained >10 patients with tinnitus for >3 months and utilized 10 to 20 electroencephalography coordinates. Study outcomes were considered positive if the treatment arm reported a significant reduction in the primary tinnitus score relative to sham. Results There were 1211 studies screened. Nineteen studies met the inclusion criteria, and 8 unique stimulation sites were reported. Studies had 53.7 ± 46.0 patients (mean ± SD). The mean duration of follow-up was 10.3 ± 9.6 weeks. Positive outcomes regarding tinnitus suppression were reported in 5 of 5 (100%) studies stimulating the temporoparietal junction midway between T3 and P3 or between T4 and P4. Tinnitus suppression at all other sites was less frequent with a combined success rate of only 8 of 14 (57.1%). Conclusion Significant heterogeneity exists in the literature in regard to the optimal transcranial magnetic stimulation target. These preliminary findings suggest that the temporoparietal junction midway between T3 and P3 or T4 and P4 is a promising nonauditory rTMS target in the setting of chronic tinnitus. Future research should elucidate the effectiveness of this site for tinnitus suppression.

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Exploring the cognitive effects of hearing loss in adult rats: Implications for visuospatial attention, social behavior, and prefrontal neural activity

Stenzel,

Alam,

Witte

et al. 2025

Neuroscience

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A tale of two tinnituses: Does hearing status influence central tinnitus localization?

Cited by 3 publications

References 26 publications

Processing of auditory information in forebrain regions after hearing loss in adulthood: Behavioral and electrophysiological studies in a rat model

Processing of auditory information in forebrain regions after hearing loss in adulthood: Behavioral and electrophysiological studies in a rat model

Is There an Optimal Repetitive Transcranial Magnetic Stimulation Target to Treat Chronic Tinnitus?

Exploring the cognitive effects of hearing loss in adult rats: Implications for visuospatial attention, social behavior, and prefrontal neural activity

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