2021
DOI: 10.1016/j.celrep.2021.109040
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A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome

Abstract: A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome Graphical abstract Highlights d High-throughput screening identifies stabilizers of the resident ER proteome d Several FDA-approved drugs stabilize the ER proteome during ER calcium depletion d Bromocriptine is a top hit and does not act through dopamine receptors d Bromocriptine is efficacious in disease models associated with calcium dysfunction

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Cited by 18 publications
(32 citation statements)
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“…However, these treatments do not directly address the cellular deficits that manifest following elevated temperatures. As ER exodosis represents a novel drug-targetable cellular mechanism of dysfunction, our findings have implications for the treatment of hyperthermia-associated impairments [73]. Furthermore, the convergence of elevated temperatures with caffeine or MDMA exposure to potentiate ER exodosis constitutes a therapeutic opportunity for decreasing drug-induced cellular toxicity associated with club drug usage.…”
Section: Discussionmentioning
confidence: 77%
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“…However, these treatments do not directly address the cellular deficits that manifest following elevated temperatures. As ER exodosis represents a novel drug-targetable cellular mechanism of dysfunction, our findings have implications for the treatment of hyperthermia-associated impairments [73]. Furthermore, the convergence of elevated temperatures with caffeine or MDMA exposure to potentiate ER exodosis constitutes a therapeutic opportunity for decreasing drug-induced cellular toxicity associated with club drug usage.…”
Section: Discussionmentioning
confidence: 77%
“…The Promega CellTiter-Glo Luminescent Cell Viability Assay (ATP assay, Promega, Madison, WI, USA) was used as per the manufacturer's protocol and in accordance with previously published data [36,73]. Briefly, an equal volume of ATP substrate was added to the cell culture plate and incubated with agitation for 2 min at room temperature.…”
Section: Atp Assaymentioning
confidence: 99%
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