A Targeted Approach to the Complications of Targeted Therapy

Single-molecule photosensitizers for NIR-II fluorescence and photoacoustic imaging guided precise anticancer phototherapy

“…[13][14][15] However, aer the complex multistep covalent conjugation, the conformation, steric freedom, and orientation of target ligands are always easy to change, which inevitably compromise their binding abilities with the targeting molecule. [16][17][18] Another strategy is to package PSs into nanoparticles with appropriate size by a nanoprecipitation method, endowing PSs with passive targeting function to tumor regions through enhanced permeability and retention (EPR) effect. 19,20 However, the prepared nanoparticles have low load rate, poor reproducibility, and risk of leakage during transport.…”