The Ostergren model is simple in form and widely used in engineering practice, also serving as the modeling basis of both the damage differentiation and crack propagation models. However, the shortcomings of the Ostergren model are that the modeling process is affected by thermomechanical fatigue (TMF) test parameters. To establish a TMF life normalized model, a modified Ostergren model based on hysteresis energy damage and TMF data for H13 steel was proposed. The model was successfully applied to TMF life prediction for 4Cr5Mo2V steel. The band of predicted life and test life is basically within the factor of 1.5. In summary, the modified Ostergren model is suitable for the TMF life prediction of Cr-Mo-V-type die-casting die steel.