A ternary model of decompression sickness in rats

Age, weight and decompression sickness in rats

“…Decompression was thereafter staged with five mins at 200kPa, five mins at 160kPa and 10 mins at 130kPa. This protocol has been shown to produce DCS signs in a predictable proportion of male rats aged 10-11 weeks (Buzzacott et al, 2014).…”

“…This protocol has been shown to produce DCS signs in a predictable proportion of male rats aged 10-11 weeks (Buzzacott et al, 2014).…”

“…For rat research though, age is confounded by weight, which increases with age ( Figure 1), and weight is a known risk factor for DCS in rats (Lillo andMacCallum, 1991, Arieli et al, 2007). Sex has also recently been shown associated with the risk of DCS in rats and VGE grades have been found higher in male divers over females (Mazur et al, 2014, Buzzacott et al, 2014, Boussuges et al, 2009 (Leening et al, 2014).…”

“…In a French study of 200 professional divers (mean age 38 years), 2.5% had a high 10-year risk and 34% had an intermediate 10-year risk of an acute coronary event (Pougnet et al, 2012). Diving too may lead to vascular dysfunction and endothelial cell death (Lambrechts et al, 2013, Wang et al, 2014. Obad et al found that post-dive flowmediated dilation of the brachial artery in divers remained reduced for two days after a single air dive (Obad et al, 2007).…”

“…With senescence the cardiovascular system undergoes complex structural and functional changes (Ardestani et al, 2015 F o r P e e r R e v i e w O n l y ). Diving too may lead to vascular dysfunction and endothelial cell death (Lambrechts et al, 2013, Wang et al, 2014.…”