The speed value of 30 km/h should not be exceeded in urban areas, both to ensure safety requirements for all categories of users and to improve the overall quality of life in urban areas. Moreover, it is necessary not only to comply with the prescribed maximum speed, but also to ensure a uniform speed by limiting the variations in relation to the average value within an acceptable range of variation. An original analysis methodology is therefore proposed, useful for both technicians and administrators to verify the effectiveness of traffic calming measures, especially in areas where these measures are widely used, such as Zones 30. This methodology, called SPEIR (acronym for Speed Profile, Effectiveness Indicators and Results, which are the keywords of the three steps into which the proposed methodology is divided), is divided into three operational steps necessary to both verify the effectiveness of existing traffic calming measures in a given context and to plan new traffic calming measures to be implemented in specific urban sectors to be requalified and revitalized. Finally, three case studies are presented where the application of the SPEIR methodology is useful not only for understanding the operational steps in the application of the methodology itself, but also for understanding the differences in terms of the safety performance that the various traffic calming measures provide to the users of the urban streets where such measures are present.