A therapeutic polyelectrolyte–vitamin C nanoparticulate system in polyvinyl alcohol–alginate hydrogel: An approach to treat skin and soft tissue infections caused by Staphylococcus aureus

George, Liya; Bavya, M. C.; Rohan, K. Vimal; Srivastava, Rohit

doi:10.1016/j.colsurfb.2017.09.030

Cited by 31 publications

(13 citation statements)

References 57 publications

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“…The wound site in chronic wounds is larger than the noticeable lesion, which is caused due to the pathological injury to tissues around the wound where the integrity of the skin is damaged [47][48][49][50][51][52]. The tissues around and underneath the chronic wounds are similarly influenced by the primary abnormality causing ulceration [42,[53][54][55][56][57][58]. The factors (local and systemic) influencing wound recovery include insufficient blood supply, the existence of foreign particles that hinder the tissue repair, the constant presence of microbes and infection, wound dehiscence, impairment of venous drainage, decreased macrophage activity, and increased MMP levels [59][60][61][62][63][64][65].…”

Section: Pathophysiology Of Wound Healingmentioning

confidence: 99%

Nanomaterial-Based Therapy for Wound Healing

2022

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Poor wound healing affects millions of people globally, resulting in increased mortality rates and associated expenses. The three major complications associated with wounds are: (i) the lack of an appropriate environment to enable the cell migration, proliferation, and angiogenesis; (ii) the microbial infection; (iii) unstable and protracted inflammation. Unfortunately, existing therapeutic methods have not solved these primary problems completely, and, thus, they have an inadequate medical accomplishment. Over the years, the integration of the remarkable properties of nanomaterials into wound healing has produced significant results. Nanomaterials can stimulate numerous cellular and molecular processes that aid in the wound microenvironment via antimicrobial, anti-inflammatory, and angiogenic effects, possibly changing the milieu from nonhealing to healing. The present article highlights the mechanism and pathophysiology of wound healing. Further, it discusses the current findings concerning the prospects and challenges of nanomaterial usage in the management of chronic wounds.

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Section: Pathophysiology Of Wound Healingmentioning

confidence: 99%

Nanomaterial-Based Therapy for Wound Healing

2022

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“…63,64 This strategy decreases the side effects of drugs because NPs in wound dressings can directly deliver lowered drug doses and release them into the wound with a greater efficacy. Until now, numerous kinds of NPs carrying therapeutic agents have been 65,69 growth factors, 83 and nucleic acid, 84 can be delivered to wound sites directly and subsequently released in a sustained manner.…”

Section: Nanoparticles As Carriers Of Therapeutic Agents For Antibact...mentioning

confidence: 99%

Nanoparticle-Based Wound Dressing: Recent Progress in the Detection and Therapy of Bacterial Infections

et al. 2020

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Bacterial infections in wounds often delay the healing process, and may seriously threaten human life. It is urgent to develop wound dressings to effectively detect and treat bacterial infections. Nanoparticles have been extensively used in wound dressings because of their specific properties. This review highlights the recent progress on nanoparticle-based wound dressings for bacterial detection and therapy. Specifically, nanoparticles have been applied as intrinsic antibacterial agents or drug delivery vehicles to treat bacteria in wounds. Moreover, nanoparticles with photothermal or photodynamic property have also been explored to endow wound dressings with significant optical properties to further enhance their bactericidal effect. More interestingly, nanoparticle-based smart dressings have been recently explored for bacteria detection and treatment, which enables an accurate assessment of bacterial infection and a more precise control of on-demand therapy.

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“…Wound healing comprises four main overlapping stages: (1) coagulation, (2) inflammation, (3) cell proliferation and matrix repair and (4) epithelialization and scar tissue remodeling (Schultz et al, ). The installation of an infection hampers this process since the bacteria disturb the wound healing cascade through toxins and proteases secretion, hence augmenting the rate of resistance to antibiotics (George, Bavya, Rohan, & Srivastava, ).…”

Section: Pathophysiology Of Skin and Soft Tissue Infections (Sstis)mentioning

confidence: 99%

Herbal medicines to the treatment of skin and soft tissue infections: advantages of the multi‐targets action

Amparo

Seibert

Vieira

et al. 2019

Phytotherapy Research

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The research for new treatments of skin and soft tissue infections (SSTIs) is important due to their high prevalence and number of hospitalizations. The purpose of this review is to address the pathophysiology of SSTIs to highlight the advantages of herbal medicines to their treatment, showing examples of species and compounds with multi‐targets action. SSTIs have a complex physiopathology involving the microorganism, as well as inflammation and difficult healing. Therefore, antimicrobial, anti‐inflammatory, antioxidant and healing activities are an approach possible for their treatment. Herbal medicines have a wide diversity of biological compounds, mainly phenolic compounds that may act on different targets and also have synergism between them. Therefore, a single medicine may have the four key activities that allied allow eliminating the infection, control the inflammation process and accelerating the healing process, preventing complications with chronic infections.

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A therapeutic polyelectrolyte–vitamin C nanoparticulate system in polyvinyl alcohol–alginate hydrogel: An approach to treat skin and soft tissue infections caused by Staphylococcus aureus

Cited by 31 publications

References 57 publications

Nanomaterial-Based Therapy for Wound Healing

Nanomaterial-Based Therapy for Wound Healing

Nanoparticle-Based Wound Dressing: Recent Progress in the Detection and Therapy of Bacterial Infections

Herbal medicines to the treatment of skin and soft tissue infections: advantages of the multi‐targets action

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