A Thermal-Desorption Surface-Ionization Indicator of Narcotics and Other Drug Preparations

Examination of the effect of air atmosphere on heterogeneous reactions under surface ionization of psychotropic drug molecules

“…The geometry and dimensions of the SI ion source correspond to that of thermal desorption surface-ionization spectrometer. 28,29 The thermoemitter is made of a single crystal of molybdenum doped with iridium in the form of a hollow cylinder, that is oxidized according to the procedure. 28 The thermoemitter temperature was within the range 650-700 K. The skimmer of the SCIEX-API-III spectrometer was located at a distance corresponding to the ion detection plane.…”

Thermo-Desorption Thermo-Ionic Spectroscopy: High Sensitive Detection of Trace Amounts of Synthetic Cannabinoid Ав-Chminaca in Smoking-Mixtures

“…A modernized device "IK-Iskovich" was used to study synthetic cannabinoides by TDТIS [6,7]. Briefly, the device consists of a temperature-programmed evaporator of the compound samples under analysis and a TI triode detector through which air moves from the evaporator to the detector.…”

Application of surface ionization methods for highly sensitive and selective analysis of benzodiazepine derivatives

“…Evaporated from the band, the sample molecules move with airflow to the surface ionization detector where the molecules are ionized by SI. This device "Iskovich-1" is different from [6,10,11] by connecting with a PC and having a database of thermodesorption spectra of psychotropic preparations and calibration curves. In experiments, the emitter temperature was 700 K, air velocity 50 L/h, evaporator temperature scanning from a room temperature to 500 • C with a linear rate of 10 K/s.…”

“…For the intermediate concentration in the thermodesorption spectra, there are both peaks. Such a character of the dependence can be explained by a difference in the values of sublimation and desorption heat of the molecules from the evaporator surface [10,11]. For the great amount of the substance, molecule evaporation is defined by sublimation heat; for the small amount of the substance, all the molecule are adsorbed on the evaporator surface, and to be evaporated they have to overcome energy of desorption activation.…”

“…However, for registration of non-volatile physiologically active nitrogen bases having vapor pressure 10 −10 -10 −7 Torr at a room temperature these sensors are not good. For those purposes, an atmospheric pressure thermodesorption surface ionization (APTDSI) sensor was developed and created [6,10,11]. This sensor is based on temperature-programmed evaporation of the molecules of the sample under analysis from the evaporator to the emitter surface and allows not only registration of the trace amounts (from 10 −12 g) of narcotics in the extracted bio-samples, but also identification in accordance with more probable temperature of substance evaporation taken from the database of the thermodesorption spectra and determination of the substance amount with high accuracy in accordance with the calibration curves.…”