A thiochromenone antibiotic derived from the <i>Pseudomonas</i> quinolone signal selectively targets the Gram-negative pathogen <i>Moraxella catarrhalis</i>

Szamosvári, Dávid; Schuhmacher, Tamara; Hauck, Christof R.; Böttcher, Thomas

doi:10.1039/c9sc01090d

Cited by 13 publications

(5 citation statements)

References 29 publications

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“…This may also correlate with the degree of inhibition of HQNO when P. aeruginosa is incubated for a longer time (data not shown). Since these pqs QS signals produced by P. aeruginosa are known to act as not only the regulation of gene expression but also an antibiotic for some bacterial species (Reen et al, 2011;Szamosvári et al, 2019), the predation activity assay of B. bacteriovorus strains tested may be inactivated as shown in Figure 7.…”

Section: Discussionmentioning

confidence: 99%

Quinolone Signals Related to Pseudomonas Quinolone Signal-Quorum Sensing Inhibits the Predatory Activity of Bdellovibrio bacteriovorus

et al. 2021

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Bdellovibrio bacteriovorus is one of the predatory bacteria; therefore, it can act as a novel “living antibiotic,” unlike the current antibiotics. Here the predation of Escherichia coli by B. bacteriovorus was inhibited in the presence of Pseudomonas aeruginosa. This study investigated whether P. aeruginosa-induced predation inhibition is associated with bacterial quorum sensing (QS). Each las, rhl, or pqs QS mutant in P. aeruginosa was used to check the predatory activity of E. coli cells using B. bacteriovorus. As a result, the predatory activity of B. bacteriovorus increased in a mutant pqs QS system, whereas wild-type PA14 inhibited the predatory activity. Moreover, the addition of 4-hydroxy-2-heptylquinoline (HHQ) or the analog triggered the low predatory activity of B. bacteriovorus and killed B. bacteriovorus cells. Therefore, a defensive action of P. aeruginosa against B. bacteriovorus is activated by the pqs QS system, which produces some quinolone compounds such as HHQ.

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Section: Discussionmentioning

confidence: 99%

Quinolone Signals Related to Pseudomonas Quinolone Signal-Quorum Sensing Inhibits the Predatory Activity of Bdellovibrio bacteriovorus

et al. 2021

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“…Optical density was determined every 0.5 h at OD550 for Neisseria gonorrhoeae MS11 and at OD600 for Enterococcus faecalis . ( Szamosvári et al, 2019 ).…”

Section: Methodsmentioning

confidence: 99%

Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration

Ückert,

Rütschlin,

Gutbier

et al. 2023

Environment International

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“…Moreover, antibiotics with killing modes based on energy metabolism inhibition show a novel pipeline for drug development. A thiochromenone antibiotic derived from the Pseudomonas quinolone signal (PQS) exhibited highly potent antibiotic activity against Moraxella catarrhalis likely by inhibiting a target in the primary energy metabolism ( Szamosvári et al, 2019 ). Consistently, cellular ATP concentrations in M. catarrhalis dropped significantly after exposure to this compound.…”

Section: Narrow-spectrum Antimicrobial Agentsmentioning

confidence: 99%

Targeted Therapeutic Strategies in the Battle Against Pathogenic Bacteria

Yang

Fang

et al. 2021

Front. Pharmacol.

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The emergence and rapid spread of antibiotic resistance in pathogenic bacteria constitute a global threat for public health. Despite ongoing efforts to confront this crisis, the pace of finding new potent antimicrobials is far slower than the evolution of drug resistance. The abuse of broad-spectrum antibiotics not only accelerates the formation of resistance but also imposes a burden on the intestinal microbiota, which acts a critical role in human homeostasis. As such, innovative therapeutic strategies with precision are pressingly warranted and highly anticipated. Recently, target therapies have achieved some breakthroughs by the aid of modern technology. In this review, we provide an insightful illustration of current and future medical targeted strategies, including narrow-spectrum agents, engineered probiotics, nanotechnology, phage therapy, and CRISPR-Cas9 technology. We discuss the recent advances and potential hurdles of these strategies. Meanwhile, the possibilities to mitigate the spread of resistance in these approaches are also mentioned. Altogether, a better understanding of the advantages, disadvantages, and mechanisms of action of these targeted therapies will be conducive to broadening our horizons and optimizing the existing antibacterial approaches.

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A thiochromenone antibiotic derived from the Pseudomonas quinolone signal selectively targets the Gram-negative pathogen Moraxella catarrhalis

Abstract: Scaffold engineering of the Pseudomonas quinolone signal results in a highly potent antibiotic with unprecedented species selectivity.

Cited by 13 publications

References 29 publications

Quinolone Signals Related to Pseudomonas Quinolone Signal-Quorum Sensing Inhibits the Predatory Activity of Bdellovibrio bacteriovorus

Quinolone Signals Related to Pseudomonas Quinolone Signal-Quorum Sensing Inhibits the Predatory Activity of Bdellovibrio bacteriovorus

Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration

Targeted Therapeutic Strategies in the Battle Against Pathogenic Bacteria

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