A three-dimensional (3D) liver–kidney on a chip with a biomimicking circulating system for drug safety evaluation

Huang, Qihong; Yang, Tianhao; Song, Yunpeng; Sun, Wenxuan; Xu, Jian; Cheng, Ya; Yin, Ruixue; Zhu, Lili; Zhang, Mengting; Ma, Lei; Li, Honglin; Zhang, Hongbo

doi:10.1039/d3lc00980g

Lab Chip

2024

DOI: 10.1039/d3lc00980g

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A three-dimensional (3D) liver–kidney on a chip with a biomimicking circulating system for drug safety evaluation

Qihong Huang,

Tianhao Yang,

Yunpeng Song

et al.

Abstract: The liver and kidneys are the major detoxifying organs in the human body and play an important role in pharmacokinetics. Drug-induced hepatotoxicity and nephrotoxicity can cause irreversible damage to the...

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Cited by 2 publications

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Harnessing the power of artificial intelligence for human living organoid research

Wang,

Li,

You

et al. 2024

Bioactive Materials

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Harnessing the power of artificial intelligence for human living organoid research

Wang,

Li,

You

et al. 2024

Bioactive Materials

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Revolutionizing Drug Discovery: The Impact of Distinct Designs and Biosensor Integration in Microfluidics-Based Organ-on-a-Chip Technology

Yuan,

Hay

et al. 2024

Biosensors

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Traditional drug development is a long and expensive process with high rates of failure. This has prompted the pharmaceutical industry to seek more efficient drug development frameworks, driving the emergence of organ-on-a-chip (OOC) based on microfluidic technologies. Unlike traditional animal experiments, OOC systems provide a more accurate simulation of human organ microenvironments and physiological responses, therefore offering a cost-effective and efficient platform for biomedical research, particularly in the development of new medicines. Additionally, OOC systems enable quick and real-time analysis, high-throughput experimentation, and automation. These advantages have shown significant promise in enhancing the drug development process. The success of an OOC system hinges on the integration of specific designs, manufacturing techniques, and biosensors to meet the need for integrated multiparameter datasets. This review focuses on the manufacturing, design, sensing systems, and applications of OOC systems, highlighting their design and sensing capabilities, as well as the technical challenges they currently face.

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A three-dimensional (3D) liver–kidney on a chip with a biomimicking circulating system for drug safety evaluation

Abstract: The liver and kidneys are the major detoxifying organs in the human body and play an important role in pharmacokinetics. Drug-induced hepatotoxicity and nephrotoxicity can cause irreversible damage to the...

Cited by 2 publications

References 48 publications

Harnessing the power of artificial intelligence for human living organoid research

Harnessing the power of artificial intelligence for human living organoid research

Revolutionizing Drug Discovery: The Impact of Distinct Designs and Biosensor Integration in Microfluidics-Based Organ-on-a-Chip Technology

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