A Ti<sub>3</sub>C<sub>2</sub> MXene-integrated near-infrared-responsive multifunctional porous scaffold for infected bone defect repair

Zhang, Linli; Zhang, Hui; Zhou, Hongling; Tan, Yi; Zhang, Zhengmin; Yang, Wei; Zhao, Lixing; Zhao, Zhihe

doi:10.1039/d3tb01578e

Cited by 6 publications

(2 citation statements)

References 72 publications

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“…Bioprinting of human mesenchymal stem cells incorporating Ti 3 C 2 T x MXene hydrogel-induced spontaneous osteodifferentiation . Ti 3 C 2 MXene composite hydrogels are endowed with photothermal, antibacterial, ROS-scavenging properties, and accelerate bone regeneration in infected bone defects. , Ti 3 C 2 MXene-based hydrogels display robust antibacterial, osteogenesis-promoting capability, and hold promising countermeasures for postoperative healing of osteosarcoma . Most of the studies are on Ti 3 C 2 T x MXene, with limited knowledge on Mo 2 Ti 2 C 3 MXene.…”

Section: Resultsmentioning

confidence: 99%

Conductive and Enhanced Mechanical Strength of Mo₂Ti₂C₃ MXene-Based Hydrogel Promotes Neurogenesis and Bone Regeneration in Bone Defect Repair

Wang,

Hsu,

Wang

et al. 2024

ACS Appl. Mater. Interfaces

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Bone defects are common with increasing highenergy fractures, tumor bone invasion, and implantation revision surgery. Bone is an electroactive tissue that has electromechanical interaction with collogen, osteoblasts, and osteoclasts. Hydrogel provides morphological plasticity and extracellular matrix (ECM) 3D structures for cell survival, and is widely used as a bone engineering material. However, the hydrogels have poor mechanical intensity and lack of cell adhesion, slow gelation time, and limited conductivity. MXenes are novel nanomaterials with hydrophilic groups that sense cell electrophysiology and improve hydrogel electric conductivity. Herein, gelatin had multiple active groups (NH2, OH, and COOH) and an accelerated gelation time. Acrylamide has Schiff base bonds to cross-link with gelatin and absorb metal ions. Deacetylated chitosan improved cell adhesion and active groups to connect MXene and acrylamide. We constructed Mo 2 Ti 2 C 3 MXene hydrogel with improved elastic modulus and viscosity, chemical cross-linking structure, electric conductivity, and good compatibility. Mo 2 Ti 2 C 3 MXene hydrogel exhibits outstanding osteogenesis in vitro. Mo 2 Ti 2 C 3 MXene hydrogel promotes osteogenesis via alkaline phosphatase (ALP) and alizarin red S (ARS) staining, improving osteogenic marker genes and protein expressions in vitro. Mo 2 Ti 2 C 3 MXene hydrogel aids new bone formation in the in vivo calvarial bone defect model via micro-CT and histology. Mo 2 Ti 2 C 3 MXene hydrogel facilitates neurogenesis factors nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) expression, and aids newly born neuron marker Tuj-1 and sensory neuron marker serotonin (5-HT) and osteogenesis pathway proteins, runt-related transcription factor 2 (Runx2), osteocalcin (OCN), SMAD family member 4 (SMAD4), and bone morphogenetic protein-2 (BMP2) in the bone defect repair process. Mo 2 Ti 2 C 3 MXene hydrogel promotes osteogenesis and neurogenesis, which extends its biomedical application in bone defect reconstruction.

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Section: Resultsmentioning

confidence: 99%

Conductive and Enhanced Mechanical Strength of Mo₂Ti₂C₃ MXene-Based Hydrogel Promotes Neurogenesis and Bone Regeneration in Bone Defect Repair

Wang,

Hsu,

Wang

et al. 2024

ACS Appl. Mater. Interfaces

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“…Composite nanoparticles generate more 1 O 2 under 660 nm laser irradiation with the increase in the PDA content, reducing the minimum inhibitory concentration against E. coli and S. aureus to approximately 0.07 mg/mL. Additionally, the PDA coating further enhances the antioxidative and antibacterial abilities of Ti 3 C 2 T x , providing the scaffold with excellent ROS scavenging capacity [ 100 ] and tissue adhesion properties [ 101 ], thereby promoting wound healing in diabetic infection wounds [ 102 ] and wounds infected with multidrug-resistant bacteria [ 103 ] ( Figure 5 ). Moreover, PDA coating can passivate the sharp edges of Ti 3 C 2 T x nanosheets, preventing damage to normal tissue cells [ 104 ].…”

Section: Classification Of the Ti 3 C 2 ...mentioning

confidence: 99%

Research Progress on Ti3C2Tx-Based Composite Materials in Antibacterial Field

Chen,

Wang,

Chen

et al. 2024

Molecules

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The integration of two-dimensional Ti3C2Tx nanosheets and other materials offers broader application options in the antibacterial field. Ti3C2Tx-based composites demonstrate synergistic physical, chemical, and photodynamic antibacterial activity. In this review, we aim to explore the potential of Ti3C2Tx-based composites in the fabrication of an antibiotic-free antibacterial agent with a focus on their systematic classification, manufacturing technology, and application potential. We investigate various components of Ti3C2Tx-based composites, such as metals, metal oxides, metal sulfides, organic frameworks, photosensitizers, etc. We also summarize the fabrication techniques used for preparing Ti3C2Tx-based composites, including solution mixing, chemical synthesis, layer-by-layer self-assembly, electrostatic assembly, and three-dimensional (3D) printing. The most recent developments in antibacterial application are also thoroughly discussed, with special attention to the medical, water treatment, food preservation, flexible textile, and industrial sectors. Ultimately, the future directions and opportunities are delineated, underscoring the focus of further research, such as elucidating microscopic mechanisms, achieving a balance between biocompatibility and antibacterial efficiency, and investigating effective, eco-friendly synthesis techniques combined with intelligent technology. A survey of the literature provides a comprehensive overview of the state-of-the-art developments in Ti3C2Tx-based composites and their potential applications in various fields. This comprehensive review covers the variety, preparation methods, and applications of Ti3C2Tx-based composites, drawing upon a total of 171 English-language references. Notably, 155 of these references are from the past five years, indicating significant recent progress and interest in this research area.

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Coaxial 3D Printing Scaffolds with Sequential Antibacterial and Osteogenic Functions to Effectively Repair Infected Mandibular Defects

Zhang,

Sun,

Zhang

et al. 2024

Adv Funct Materials

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Infected mandibular defects pose a formidable challenge without an entirely satisfactory repair strategy. Here, a coaxial 3D printing scaffold comprising a shell loaded is dveloped with the antibiotic minocycline hydrochloride and a core wrapped with traditional Chinese medicine antler powers. This study is conducted to evaluate the efficacy of the scaffold in facilitating the repair of infected mandibular defects. In vitro investigations exhibit that this construct possesses a porous microstructure, exceptional mechanical properties, appropriate degradability, acceptable water absorption capacity, and satisfactory biocompatibility. Transcriptome analyses further reveal a notable upregulation of relevant genes and signaling pathways associated with cell activity, osteogenesis, and angiogenesis. In vivo rat (Φ = 5 mm) and rabbit (5 mm × 4 mm × 10 mm) mandibular defect models confirm the scaffold's ability to sequentially regulate bone healing by suppressing infection and inflammation, followed by promoting osteogenesis and angiogenesis. This advanced graft holds significant translational potential for infectious bone regeneration.

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A Ti₃C₂ MXene-integrated near-infrared-responsive multifunctional porous scaffold for infected bone defect repair

Abstract: The porous PMME/PEI/PDA/MXene scaffold was fabricated through the VIPS and dopamine-assisted co-deposition processes. The as-prepared scaffold possesses anti-bacterial, ROS scavenging, and osteogenic abilities.

Cited by 6 publications

References 72 publications

Conductive and Enhanced Mechanical Strength of Mo₂Ti₂C₃ MXene-Based Hydrogel Promotes Neurogenesis and Bone Regeneration in Bone Defect Repair

Conductive and Enhanced Mechanical Strength of Mo₂Ti₂C₃ MXene-Based Hydrogel Promotes Neurogenesis and Bone Regeneration in Bone Defect Repair

Research Progress on Ti3C2Tx-Based Composite Materials in Antibacterial Field

Coaxial 3D Printing Scaffolds with Sequential Antibacterial and Osteogenic Functions to Effectively Repair Infected Mandibular Defects

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A Ti3C2 MXene-integrated near-infrared-responsive multifunctional porous scaffold for infected bone defect repair

Abstract: The porous PMME/PEI/PDA/MXene scaffold was fabricated through the VIPS and dopamine-assisted co-deposition processes. The as-prepared scaffold possesses anti-bacterial, ROS scavenging, and osteogenic abilities.

Cited by 6 publications

References 72 publications

Conductive and Enhanced Mechanical Strength of Mo2Ti2C3 MXene-Based Hydrogel Promotes Neurogenesis and Bone Regeneration in Bone Defect Repair

Conductive and Enhanced Mechanical Strength of Mo2Ti2C3 MXene-Based Hydrogel Promotes Neurogenesis and Bone Regeneration in Bone Defect Repair

Research Progress on Ti3C2Tx-Based Composite Materials in Antibacterial Field

Coaxial 3D Printing Scaffolds with Sequential Antibacterial and Osteogenic Functions to Effectively Repair Infected Mandibular Defects

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Product

Resources

About

A Ti₃C₂ MXene-integrated near-infrared-responsive multifunctional porous scaffold for infected bone defect repair

Conductive and Enhanced Mechanical Strength of Mo₂Ti₂C₃ MXene-Based Hydrogel Promotes Neurogenesis and Bone Regeneration in Bone Defect Repair

Conductive and Enhanced Mechanical Strength of Mo₂Ti₂C₃ MXene-Based Hydrogel Promotes Neurogenesis and Bone Regeneration in Bone Defect Repair