A ‘tile’ tale: Hierarchical self-assembly of DNA lattices

Chandrasekaran, Arun Richard; Zhuo, Rebecca

doi:10.1016/j.apmt.2015.11.004

Cited by 48 publications

(29 citation statements)

References 61 publications

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“…Seeman’s original vision was to use DNA as a framework to crystallize other hard-to-crystallize macromolecules. Early work on DNA-based construction mostly involved the creation of DNA junctions, motifs and devices 2 – 4 , and, over the past four decades, multiple strategies have been developed to create diverse architectures using DNA 5 . The library of DNA nanostructures, ranging from the nanometre to the micrometre scale 6 – 8 , now includes geometric patterns 9 , polyhedral objects 10 , nanoscale bunnies 11 , a box with a lid 12 , a cargo-moving assembly line 13 and even a miniature Mona Lisa 14 .…”

Section: Introductionmentioning

confidence: 99%

Nuclease resistance of DNA nanostructures

2021

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DNA nanotechnology has progressed from proof-of-concept demonstrations of structural design towards application-oriented research. As a natural material with excellent self-assembling properties, DNA is an indomitable choice for various biological applications, including biosensing, cell modulation, bioimaging and drug delivery. However, a major impediment to the use of DNA nanostructures in biological applications is their susceptibility to attack by nucleases present in the physiological environment. Although several DNA nanostructures show enhanced resistance to nuclease attack compared with duplexes and plasmid DNA, this may be inadequate for practical application. Recently, several strategies have been developed to increase the nuclease resistance of DNA nanostructures while retaining their functions, and the stability of various DNA nanostructures has been studied in biological fluids, such as serum, urine and cell lysates. This Review discusses the approaches used to modulate nuclease resistance in DNA nanostructures and provides an overview of the techniques employed to evaluate resistance to degradation and quantify stability.

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Section: Introductionmentioning

confidence: 99%

Nuclease resistance of DNA nanostructures

2021

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“…15 To this end, a variety of DNA 'tiles' with high structural integrity have been developed. 16 One notable example is the doublecrossover (DX) tile. 17 In contrast to the Holliday junction, which features one crossover between two DNA duplexes, the DX tile features two crossovers ( Fig.…”

Section: Dna Tilesmentioning

confidence: 99%

High-order structures from nucleic acids for biomedical applications

Hill

Hall

2020

Mater. Chem. Front.

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“…DNA nanostructures have found applications in many fields. Periodic arrays assembled from individual DNA motifs provide control over spatial positioning of functional molecules . One of their main uses is to create enzyme cascades, in which the reactivity of enzymes of interest was found to be higher when confined within nanostructures compared to those in free solution.…”

Section: Introductionmentioning

confidence: 99%

A Molecular Hero Suit for In Vitro and In Vivo DNA Nanostructures

Kizer

Linhardt

Chandrasekaran

et al. 2019

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Precise control of DNA base pairing has rapidly developed into a field full of diverse nanoscale structures and devices that are capable of automation, performing molecular analyses, mimicking enzymatic cascades, biosensing, and delivering drugs. This DNA‐based platform has shown the potential of offering novel therapeutics and biomolecular analysis but will ultimately require clever modification to enrich or achieve the needed “properties” and make it whole. These modifications total what are categorized as the molecular hero suit of DNA nanotechnology. Like a hero, DNA nanostructures have the ability to put on a suit equipped with honing mechanisms, molecular flares, encapsulated cargoes, a protective body armor, and an evasive stealth mode.

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A ‘tile’ tale: Hierarchical self-assembly of DNA lattices

Cited by 48 publications

References 61 publications

Nuclease resistance of DNA nanostructures

Nuclease resistance of DNA nanostructures

High-order structures from nucleic acids for biomedical applications

A Molecular Hero Suit for In Vitro and In Vivo DNA Nanostructures

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