A Time Resolved DPIV In-Vitro Evaluation of Coronary Stents in Realistic Conditions: Part II — Effect of Stent Design

Abstract

Cardiovascular disease has historically been the leading cause of death in the US [1], and accounts for approximately one third of all deaths worldwide [2]. Coronary artery disease in particular accounts for over fifty percent of these deaths and in 2004 was the single largest killer, affecting approximately 15 million people every year [1]. Coronary stenting was approved in 1994 by the FDA, and has become one of the leading treatments for the disease. However, problems persist in both bare metal and drug-eluting stents (DESs) with restenosis and thrombosis. It is well accepted that disruptions in arterial wall shear stress (WSS), especially low WSS, are linked to alterations in the endothelial cell layer and ultimately disease [3], although the exact mechanisms are still uncertain. Additionally, studies have shown that stent design is closely linked to clinical outcomes [4].