A time-resolved near-infrared phosphorescent iridium(<scp>iii</scp>) complex for fast and highly specific peroxynitrite detection and bioimaging applications

Li, Yuanyan; Wu, Yongquan; Chen, Luyan; Zeng, Hong; Chen, Xiaoyong; Lun, Weican; Fan, Xiaolin; Wong, Wai Yeung

doi:10.1039/c9tb01673b

Cited by 33 publications

(24 citation statements)

References 48 publications

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“…Before and after the reactions, the emission properties of the probes changed by a wide margin, in terms of emission wavelength, emission intensity or emission lifetime. With the help of these changes, not limited to bio-imaging, qualitative or even semi-quantitative analyses have been realized to detect certain species of particles or structural units, such as proton (H + ) ( Zheng et al., 2017 ), cysteine (Cys) and homocysteine (Hcy) ( Li et al., 2020 ; Wu et al., 2017 ), peroxynitrite (ONOO − ) ( Li et al., 2019 ; Wu et al., 2020 ), l-azidohomoalanine ( Wang et al., 2017a ), human carboxylesterase 2 (hCE2) ( Yan et al., 2018 ), and phase-separated biomolecular condensates ( Yan et al., 2021 ).…”

Section: Applications In Biological Imagingmentioning

confidence: 99%

“…In 2019, Fan et al. reported a cationic Ir(III) complex FNO2 based on btq as the cyclometalated ligands for specific peroxynitrite (ONOO − ) detection ( Figure 22 A) ( Li et al., 2019 ). The nitro groups on the 2,4-dinitroaniline of the ancillary ligand are quenchers for phosphorescent emission.…”

Section: Applications In Biological Imagingmentioning

confidence: 99%

Section: Applications In Biological Imagingmentioning

confidence: 99%

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Near-infrared emitting iridium complexes: Molecular design, photophysical properties, and related applications

Zhang

Qiao

2021

iScience

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Summary Organic light-emitting diodes (OLEDs) have become popular displays from small screens of wearables to large screens of televisions. In those active-matrix OLED displays, phosphorescent iridium(III) complexes serve as the indispensable green and red emitters because of their high luminous efficiency, excellent color tunability, and high durability. However, in contrast to their brilliant success in the visible region, iridium complexes are still underperforming in the near-infrared (NIR) region, particular in poor luminous efficiency according to the energy gap law. In this review, we first recall the basic theory of phosphorescent iridium complexes and explore their full potential for NIR emission. Next, the recent advances in NIR-emitting iridium complexes are summarized by highlighting design strategies and the structure-properties relationship. Some important implications for controlling photophysical properties are revealed. Moreover, as promising applications, NIR-OLEDs and bio-imaging based on NIR Ir(III) complexes are also presented. Finally, challenges and opportunities for NIR-emitting iridium complexes are envisioned.

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Section: Applications In Biological Imagingmentioning

confidence: 99%

Section: Applications In Biological Imagingmentioning

confidence: 99%

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Near-infrared emitting iridium complexes: Molecular design, photophysical properties, and related applications

Zhang

Qiao

2021

iScience

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“…Response within seconds of the analytes was determined; it was designed for long luminescence lifetimes. Additional virtues of such an Ir based are time-resolved and time-resolved phospholuminescence [171]. Li and coworkers reported an iridium system named FNO2 in which peroxynitrite is detected over O 2 −.…”

Section: A Recent Report About Reductants and Ros In The Context Of Probing And Fluorescencementioning

confidence: 99%

Discussions of Fluorescence in Selenium Chemistry: Recently Reported Probes, Particles, and a Clearer Biological Knowledge

et al. 2021

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In this review from literature appearing over about the past 5 years, we focus on selected selenide reports and related chemistry; we aimed for a digestible, relevant, review intended to be usefully interconnected within the realm of fluorescence and selenium chemistry. Tellurium is mentioned where relevant. Topics include selenium in physics and surfaces, nanoscience, sensing and fluorescence, quantum dots and nanoparticles, Au and oxide nanoparticles quantum dot based, coatings and catalyst poisons, thin film, and aspects of solar energy conversion. Chemosensing is covered, whether small molecule or nanoparticle based, relating to metal ion analytes, H2S, as well as analyte sulfane (biothiols—including glutathione). We cover recent reports of probing and fluorescence when they deal with redox biology aspects. Selenium in therapeutics, medicinal chemistry and skeleton cores is covered. Selenium serves as a constituent for some small molecule sensors and probes. Typically, the selenium is part of the reactive, or active site of the probe; in other cases, it is featured as the analyte, either as a reduced or oxidized form of selenium. Free radicals and ROS are also mentioned; aggregation strategies are treated in some places. Also, the relationship between reduced selenium and oxidized selenium is developed.

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“…The reaction of the complex with peroxynitrite removes 2,4-dinitroaniline within seconds, and the luminescence intensity of the probe is increased. 16 Zhang et al combined polydopamine nanoparticles with NIR phosphorescent iridium(III) complexes and applied them to imaging of intracellular pH values in the skin. 17 These examples 16 , 17 clearly demonstrated that the application of iridium phosphors with a large Stokes shift and a long luminescence lifetime help to avoid the interference with background autofluorescence and give higher sensitivity and resolution in biological imaging.…”

Section: Introductionmentioning

confidence: 99%

Glucose Sensing in Human Whole Blood Based on Near-Infrared Phosphors and Outlier Treatment with the Programming Language “R”

et al. 2021

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A near-infrared paper-based analytical device ( NIR-PAD ) for glucose detection in whole blood was based on iridium(III) metal complexes embedded in a three-dimensional (3D) enzyme gel. These complexes emit NIR luminescence, can avoid interference from the color of blood, and increase the sensitivity of sensing glucose. The glucose reaction behaviors of another two different iridium(III) and platinum(II) complexes were also tested. When the glucose solution was added to the device, the oxidation of glucose by glucose oxidase caused oxygen consumption and increased the intensity of the phosphorescence emission. To the best of our knowledge, this is the first time that data have been treated with the programming language “R”, which uses Tukey’s test to identify the outliers in the data and calculate a median for establishing a calibration curve, in order to improve the accuracy of NIR-PADs for sensing glucose. Compared with other published devices, NIR-PADs exhibit a wider linear range (1–30 mM, [relative emission intensity] = 0.0250[glucose] + 0.0451, and R 2 = 0.9984), a low detection limit (0.7 mM), a short response time (<2 s), and a small sample volume (2 μL). Finally, blood specimens were obtained from 19 patients enrolled in Taipei Veterans General Hospital under an approved IRB protocol (Taiwan; 2017-12-002CC). The sensors exhibited remarkable characteristics for glucose detection in comparison with other methods, including the clinical method in hospitals as well as those without blood sample pretreatment or a dilution factor. The above results confirm that NIR-PAD sensors can be put to practical use for glucose detection.

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A time-resolved near-infrared phosphorescent iridium(iii) complex for fast and highly specific peroxynitrite detection and bioimaging applications

Abstract: A novel near-infrared phosphorescent iridium(iii) complex was developed for fast and highly specific peroxynitrite detection through the use of time-resolved emission spectra.

Cited by 33 publications

References 48 publications

Near-infrared emitting iridium complexes: Molecular design, photophysical properties, and related applications

Near-infrared emitting iridium complexes: Molecular design, photophysical properties, and related applications

Discussions of Fluorescence in Selenium Chemistry: Recently Reported Probes, Particles, and a Clearer Biological Knowledge

Glucose Sensing in Human Whole Blood Based on Near-Infrared Phosphors and Outlier Treatment with the Programming Language “R”

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