A tissue culture model for mercury-selenium interactions

Influence of selenium treatment on the acute toxicity of dibutyltin dichloride in rats

“…Selenium reacts in vivo with mercury and forms albumin-mercury-selenite complexes, increases the mercury elimination and reduces the lethality and pathohistological changes in organs caused by toxic doses of mercury [18,38] . Earlier studies refer to a lower toxicity of mercury given in complex with Na-selenite compared to a single treatment with mercury [39,40] .…”

Metabolic Interactions of Selenium with Cadmium, Mercury, and Silver

“…Embryolethality was decreased and the incidence of cleft palate was increased in pregnant mice receiving high doses of selenite combined with high doses of methylmercury (Nobunaga et al, 1979). In addition to whole animal studies, a tissue culture model for mercury-selenium interactions has been described (Potter and Matrone, 1977). Chang's liver cells and 3T3 cells were protected against mercury toxicity by selenite in these cultures.…”

Influence of daily oral prophylactic selenium treatment on the dibutyltin dichloride (DBTC)-induced pancreatitis in rats

“…Another way of diminishing the toxic reactions of metals and organometals in the organism could be the formation of complexes consisting of selenium and noxious substances. As such selenium decreases the toxicity of mercury in vivo via formation of albumin-mercury-selenite complexes accompanied by increasing mercury elimination in urine (Schrauzer, 1990[35], 1998[34]; Wu et al, 1990[48]; Hennighausen and Lange, 1980[9]; Potter and Matrone, 1977[29]). Accordingly, selenium complexes with DBTC as cause of the reduced toxicity appear feasible.…”