A-to-I RNA editing shows dramatic up-regulation in osteosarcoma and broadly regulates tumor-related genes by altering microRNA target regions

Ge, Fuqun; Cao, Xinyue; Jiang, Yankai

doi:10.1007/s13353-023-00777-5

Cited by 9 publications

(1 citation statement)

References 74 publications

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“…RNA editing can also modulate immune responses and immune surveillance in cancer [ 124 ]. Furthermore, RNA editing may play a role in cancer by influencing the biogenesis and function of miRNAs that act as tumor suppressors or tumor receptors [ 125 – 127 ]. Recent studies have shown that overexpression of ADAR1 in mice does not initiate or accelerate cancer development, suggesting that ADAR1 overexpression itself is not sufficient to induce cancer but rather a consequence of tumor formation [ 128 , 129 ].…”

Section: Biological Functions Of Rna Editingmentioning

confidence: 99%

RNA editing enzymes: structure, biological functions and applications

Zhang,

Zhu,

Gao

et al. 2024

Cell Biosci

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With the advancement of sequencing technologies and bioinformatics, over than 170 different RNA modifications have been identified. However, only a few of these modifications can lead to base pair changes, which are called RNA editing. RNA editing is a ubiquitous modification in mammalian transcriptomes and is an important co/posttranscriptional modification that plays a crucial role in various cellular processes. There are two main types of RNA editing events: adenosine to inosine (A-to-I) editing, catalyzed by ADARs on double-stranded RNA or ADATs on tRNA, and cytosine to uridine (C-to-U) editing catalyzed by APOBECs. This article provides an overview of the structure, function, and applications of RNA editing enzymes. We discuss the structural characteristics of three RNA editing enzyme families and their catalytic mechanisms in RNA editing. We also explain the biological role of RNA editing, particularly in innate immunity, cancer biogenesis, and antiviral activity. Additionally, this article describes RNA editing tools for manipulating RNA to correct disease-causing mutations, as well as the potential applications of RNA editing enzymes in the field of biotechnology and therapy.

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