A Tool for High-Resolution Volumetric Optical Coherence Tomography by Compounding Radial-and Linear Acquired B-Scans Using Registration

Abstract

Optical coherence tomography (OCT) is a medical imaging modality that is commonly used to diagnose retinal diseases. In recent years, linear and radial scanning patterns have been proposed to acquire three-dimensional OCT data. These patterns show differences in A-scan acquisition density across the generated volumes, and thus differ in their suitability for the diagnosis of retinal diseases. While radial OCT volumes exhibit a higher A-scan sampling rate around the scan center, linear scans contain more information in the peripheral scan areas. In this paper, we propose a method to combine a linearly and radially acquired OCT volume to generate a single compound volume, which merges the advantages of both scanning patterns to increase the information that can be gained from the three-dimensional OCT data. We initially generate 3D point clouds of the linearly and radially acquired OCT volumes and use an Iterative Closest Point (ICP) variant to register both volumes. After registration, the compound volume is created by selectively exploiting linear and radial scanning data, depending on the A-scan density of the individual scans. Fusing regions from both volumes with respect to their local A-scan sampling density, we achieve improved overall anatomical OCT information in a high-resolution compound volume. We demonstrate our method on linear and radial OCT volumes for the visualization and analysis of macular holes and the surrounding anatomical structures.

Correction of refractive distortion in whole‐eye optical coherence tomography imaging of the mouse eye

“…Visually, the curvature of the corrected boundary of retina from Ref. [2]5 was contrary to the actual situation (Figure 10D), and the curvature of all boundaries was not corrected at all from Ref. [26] (Figure 10E,K).…”

“…Optical coherence tomography (OCT) is an imaging technology with great potential in the field of biomedical because of its characteristics of high resolution, high sensitivity, non-invasive and non-contact [1][2][3][4]. In recent years, it has become a golden standard for clinical diagnosis of ophthalmic diseases [5][6][7][8][9][10].…”

Biometric Technologies Based on Optical Coherence Tomography

“…The simplest and fastest mode is the acquisition of a single B-scan, but in the case of diagnostics of some lesions, better imaging can be obtained by three-dimensional radial scanning or three-dimensional linear scanning consisting of a fixed number of parallel B-scans. Article [ 5 ] proposes a method for combining linearly and radially acquired OCT volumes to generate a single high-resolution compound volume. The method consists of generating a 3D point cloud for both types of scans and then combining them using an Iterative Closest Point (ICP) variant.…”

Phase Unwrapping and Frequency Points Subdivision of the Frequency Sweeping Interferometry Based Absolute Ranging System

“…With the dominance of no ranging blind area, non-cooperative target, and high signal to noise ratio, the FSI is coming into prominence in the field of engineering application, such as optical coherence tomography [1], the measurement of three-dimensional coordinate [2] and parameters of rotors [3], important equipment manufacturing [4] and satellite formation [5]. FSI is based on the Michelson interferometer, and the distance is calculated by the beat frequency caused by the sweeping frequency and phase difference [6,7].…”