A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation

Murray, John; Burch, James A.; Streilein, Robert D.; Iannacchione, Mary Ann; Hall, Russell P.; Pinnell, Sheldon R.

doi:10.1016/j.jaad.2008.05.004

Cited by 167 publications

(118 citation statements)

References 37 publications

(44 reference statements)

Supporting

Mentioning

110

Contrasting

Unclassified

Order By: Relevance

“…UV-induced cytokine formation and tumor necrosis factor-α were evaluated by real-time PCR. The results showed that the antioxidant mixture lotion provided significant photoprotection for skin according to all evaluation methods and its mechanism of action is different from sunscreens, suggesting that they can be used as a supplement to conventional sun protectors (Murray et al, 2008). Oresajo et al (2008) evaluated the protective effects of a topical antioxidant mixture containing vitamin C, FA and phloretin against ultraviolet-induced photodamage in human skin using biomarkers of skin damage.…”

Section: Uv Protection Agentmentioning

confidence: 99%

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Brenelli

Goldbeck

Santos

et al. 2013

Braz. J. Pharm. Sci.

162

View full text Add to dashboard Cite

Ferulic acid is a phenolic acid widely distributed in the plant kingdom. It presents a wide range of potential therapeutic effects useful in the treatments of cancer, diabetes, lung and cardiovascular diseases, as well as hepatic, neuro and photoprotective effects and antimicrobial and anti-inflammatory activities. Overall, the pharmaceutical potential of ferulic acid can be attributed to its ability to scavenge free radicals. However, recent studies have revealed that ferulic acid presents pharmacological properties beyond those related to its antioxidant activity, such as the ability to competitively inhibit HMG-CoA reductase and activate glucokinase, contributing to reduce hypercholesterolemia and hyperglycemia, respectively. The present review addresses ferulic acid dietary sources, the pharmacokinetic profile, antioxidant action mechanisms and therapeutic effects in the treatment and prevention of various diseases, in order to provide a basis for understanding its mechanisms of action as well as its pharmaceutical potential.Uniterms: Ferulic acid/properties. Ferulic acid/antioxidant activity. Ferulic acid/dietary sources. Ferulic acid/therapeutic effects. Natural products. Pharmacognosy.O ácido ferúlico é um ácido fenólico amplamente distribuído no reino vegetal. Ele apresenta uma ampla gama de potenciais efeitos terapêuticos utéis no tratamento do câncer, diabetes, doenças pulmonares e cardiovasculares, bem como efeitos hepáticos, neuro e fotoprotetores, atividades antimicrobianas e antiinflamatórias. O potencial farmacêutico do ácido ferúlico pode ser atribuído à sua capacidade em sequestrar radicais livres. No entanto, estudos recentes revelaram que o ácido ferúlico apresenta propriedades farmacológicas, além da sua atividade antioxidante, como a capacidade de inibir competitivamente a HMG-CoA redutase e ativar a glucoquinase, contribuindo para reduzir a hipercolesterolemia e hiperglicemia, respectivamente. A presente revisão aborda as fontes dietéticas de ácido ferúlico, o perfil farmacocinético, os mecanismos de ação como antioxidante e efeitos terapêuticos no tratamento e prevenção de várias doenças, de modo a proporcionar uma base para a compreensão dos seus mecanismos de ação, bem como os seus potenciais farmacêuticos.Unitermos: Ácido ferúlico/propriedades. Ácido ferúlico/atividade antioxidante. Ácido ferúlico/fontes dietéticas. Ácido ferúlico/efeitos terapêuticos. Produtos naturais. Farmacognosia. INTRODUCTIONNatural antioxidants exhibit therapeutic potential for a variety of diseases such as cancer, diabetes, and cardiovascular and neurodegenerative diseases (Kayahara et al., 1999;Kim et al., 2003;Soobrattee et al., 2005) where free radicals play a key role in development (Prior et al., 1998). Recently there has been increased public and scientific interest in employing natural antioxidants instead of synthetic antioxidants, due to their potential adverse effects on health which may include carcinogenicity (Ito et al., 1983;Würtzen, 1990;Osawa et al., 1990).Antioxidants found in vegetables can ac...

show abstract

Section: Uv Protection Agentmentioning

confidence: 99%

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Brenelli

Goldbeck

Santos

et al. 2013

Braz. J. Pharm. Sci.

162

View full text Add to dashboard Cite

show abstract

“…Among the polyphenols found in our extract, efficacy of fumaric acid was depicted in psoriasis [15,16]. In various clinical studies ferulic acid was found to have protective effects against damage caused by the UV irradiation and chemically induced skin tumorigenesis [17][18][19]. Ferulic acid and sinapic acid analogues were reported to inhibit UVA induced oxidative stress in skin [20].…”

Section: Gene Expression Analysis (Real-time Qpcr)mentioning

confidence: 82%

Evaluating Antiinflammatory and Antiandrogenic Effects of Garden Cress (Lepidium sativum L.) in HaCaT cells

Türkoğlu¹,

Kılıç²,

Pekmezci³

et al. 2018

Rec.Nat.Prod.

View full text Add to dashboard Cite

Lepidium sativum L. (Brassicaceae) (Ls), garden cress, is an edible herb that is botanically related to watercress and mustard, sharing their peppery, tangy flavor and aroma. The various parts of the plant have been traditionally used for many respiratory, rheumatologic, cardiovasculary, metabolic, and gastrointestinal disorders. Several studies were performed showing its antiinflammatory, anticarcinogenic, antiproliferative as well as tissue protective effects. In all of these studies the positive effects of Ls were concluded as the result of its antioxidant features due to the polyphenols and organosulphur compounds. In this study, we investigated the molecular basis of antiinflammatory, antiproliferative, antimitotic and antiandrogenic effects of Ls leaf extract in HaCaT cells. The gene expression levels of vascular endothelial growth factor (VEGF), tumor necrosis factoralpha (TNF-α), interleukin 1-alpha (IL-1α), and 5 alpha-reductase type II (SRD5A2) were studied. Gene expressions were determined by RT-qPCR analysis. Fold change results of the gene expression analyses showed that the plant extract caused statistically significant downregulation of VEGF (0.2167, p<0.0001), p = 0.0262), and SRD5A2 (0.0567, p<0.0001). The fold change for IL-1α was 0.6900 and this result was not statistically significant (p = 0.1522). These preliminary results may partially explain the clinical success of Ls in the traditional medicine. Considering these results, topical application of Lepidium sativum extract may be beneficial for inflammatory, androgen dependent disorders of the skin.

show abstract

“…Notably, Lin et al have developed a topical formulation consisting of 15% L-ascorbic acid combined with 1% DL-α-tocopherol (17). When DL-α-tocopherol neutralizes oxidative stress in lipids, its oxidation product can be regenerated by L-ascorbic acid (28)(29)(30)(31)(32)(33)(34)(35)(36). L-(+)-ergothioneine is a potent, natural sulfur-containing antioxidant that can protect biological macromolecules against copper-dependent oxidative damage (37) and enhance DNA repair in UV-irradiated cells (38).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of trehalose-loaded liposomes against UVB-induced photodamage in human keratinocytes

Emanuele¹,

Bertona²,

Sanchís-Gomar

et al. 2014

Biomedical Reports

View full text Add to dashboard Cite

Abstract. Trehalose, a naturally occurring non-reducing disaccharide, is known to act as a major protein stabilizer that can reduce ultraviolet B (UVB)-induced corneal damage when topically applied to the eye. However, due to the low skin permeability of trehalose, which makes the development of topical formulations difficult, its use as a skin photoprotective agent has been limited. Previous findings demonstrated that liposomes may significantly improve the intracellular delivery of trehalose. Therefore, the present study aimed to assess the protective effects of trehalose-loaded liposomes against UVB-induced photodamage using the immortalized human keratinocyte cell line, HaCaT. The effects were also compared to those of the common skin photoprotective compounds, including L-carnosine, L-(+)-ergothioneine, L-ascorbic acid and DL-α-tocopherol. The levels of cyclobutane pyrimidine dimers, 8-hydroxy-2'-deoxyguanosine and protein carbonylation in HaCaT cells were used as biological markers of UVB-induced damage. Compared to other compounds, trehalose-loaded liposomes showed the highest efficacy in reducing the levels of the three markers following UVB irradiation of HaCaT cells (all P<0.001 when compared to each of the four other photoprotective compounds). Therefore, these findings indicate that there may be a clinical application for trehalose-loaded liposomes, and further studies should be performed to assess the potential usefulness in skin photoprotection and the prevention of non-melanoma skin cancer.

show abstract

A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation

Cited by 167 publications

References 37 publications

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Evaluating Antiinflammatory and Antiandrogenic Effects of Garden Cress (Lepidium sativum L.) in HaCaT cells

Protective effect of trehalose-loaded liposomes against UVB-induced photodamage in human keratinocytes

Contact Info

Product

Resources

About