2005
DOI: 10.1016/j.mcn.2005.04.004
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A transcriptional role for C/EBP β in the neuronal response to axonal injury

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Cited by 87 publications
(91 citation statements)
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“…During development, c/EBP-β signaling biases precursor cells to commit to a neural rather than glial lineage (Menard et al, 2002). c/EBP-β activity also induces axonal sprouting after axotomy, and, not surprising, regulates the expression of the neuronal markers NeuN, GAP43 and βIII tubulin (Nadeau et al, 2005). Of note, we have observed that hypoxia-induced loss of c/EBP-β is associated with a decline in both NeuN and β-III tubulin in vitro.…”
Section: Discussionmentioning
confidence: 58%
“…During development, c/EBP-β signaling biases precursor cells to commit to a neural rather than glial lineage (Menard et al, 2002). c/EBP-β activity also induces axonal sprouting after axotomy, and, not surprising, regulates the expression of the neuronal markers NeuN, GAP43 and βIII tubulin (Nadeau et al, 2005). Of note, we have observed that hypoxia-induced loss of c/EBP-β is associated with a decline in both NeuN and β-III tubulin in vitro.…”
Section: Discussionmentioning
confidence: 58%
“…10,11 C/EBPb also stimulates neurite extension through the regulated expression of structural transcripts including a-tubulin. 31 In this regard, it was recently demonstrated that MKP-1 has an important role in modulating BDNF-induced axon branching in vivo. 32 It will be especially intriguing to determine whether MKP-1-C/EBPb interactions influence axonal remodeling and tissue repair after injury.…”
Section: Resultsmentioning
confidence: 99%
“…Because the levels of SPRR1A in injured DRGs are higher than in non-injured DRG in the ATF3 transgenic mice, other downstream signals in addition to ATF3 are likely to govern SPRR1A expression. C/EBP ␤, for example, is induced after peripheral nerve injury and a functional C/EBP ␤ binding site is located on the SPRR1A promoter (Pradervand et al, 2004;Nadeau et al, 2005).…”
Section: Discussionmentioning
confidence: 99%