A transformable and biocompatible polymer series using ring-opening polymerization of cyclic silane for more effective transdermal drug delivery

Kang, Rae Hyung; Kim, Dokyoung

doi:10.1016/j.cej.2022.135989

Cited by 7 publications

(3 citation statements)

References 40 publications

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“…A transdermal drug delivery system (TDDS) utilizes the skin to administer therapeutic agents. 21 , 22 These agents permeate the skin, are absorbed into the blood vessels, and are distributed throughout the body. 23–25 TDDS offer non-invasiveness, minimal pain, first-pass metabolism bypassing, ease of administration, independence from medical personnel, and potential applicability to a wide range of hydrophilic and hydrophobic drugs.…”

Section: Introductionmentioning

confidence: 99%

Key Transdermal Patch Using Cannabidiol-Loaded Nanocarriers with Better Pharmacokinetics in vivo

Chu,

Liao,

Liu

et al. 2024

IJN

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Purpose: Cannabidiol (CBD) is a promising therapeutic drug with low addictive potential and a favorable safety profile. However, CBD did face certain challenges, including poor solubility in water and low oral bioavailability. To harness the potential of CBD by combining it with a transdermal drug delivery system (TDDS). This innovative approach sought to develop a transdermal patch dosage form with micellar vesicular nanocarriers to enhance the bioavailability of CBD, leading to improved therapeutic outcomes. Methods: A skin-penetrating micellar vesicular nanocarriers, prepared using nano emulsion method, cannabidiol loaded transdermal nanocarriers-12 (CTD-12) was presented with a small particle size, high encapsulation efficiency, and a drug-loaded ratio for CBD. The skin permeation ability used Strat-M™ membrane with a transdermal diffusion system to evaluate the CTD and patch of CTD-12 (PCTD-12) within 24 hrs. PCTD-12 was used in a preliminary pharmacokinetic study in rats to demonstrate the potential of the developed transdermal nanocarrier drug patch for future applications. Results: In the transdermal application of CTD-12, the relative bioavailability of the formulation was 3.68 ± 0.17-fold greater than in the free CBD application. Moreover, PCTD-12 indicated 2.46 ± 0.18-fold higher relative bioavailability comparing with free CBD patch in the ex vivo evaluation. Most importantly, in the pharmacokinetics of PCTD-12, the relative bioavailability of PCTD-12 was 9.47 ± 0.88-fold higher than in the oral application. Conclusion: CTD-12, a transdermal nanocarrier, represents a promising approach for CBD delivery, suggesting its potential as an effective transdermal dosage form.

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Section: Introductionmentioning

confidence: 99%

Key Transdermal Patch Using Cannabidiol-Loaded Nanocarriers with Better Pharmacokinetics in vivo

Chu,

Liao,

Liu

et al. 2024

IJN

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“…The preparation of this polymer has been studied by multiple groups − since its initial report, and although c -M 2 E was considered by one group a “model” monomer to study cyclosiloxane polymerization, information concerning PM 2 E properties is scant. Comparisons of its behavior relative to PDMS as a material or as a component of materials are very few.…”

mentioning

confidence: 99%

“…Both anionic and cationic ring-opening polymerizations are shown to be useful for end-functionalization. A recent report indicates that PM 2 E shows promise as a transdermal drug delivery vehicle that provides enhanced drug permeation efficacy. In vivo (mouse) studies indicate nontoxicity.…”

mentioning

confidence: 99%

Hemisilicone Elastomers That Are Recyclable to the Monomer

Bian

McCarthy

2022

ACS Macro Lett.

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Methyl-, vinyl-, and hydride-terminated polymers of the heterocyclic monomer, 2,2,5,5-tetramethyl-2,5-disila-1-oxacyclopentane (c-M 2 E) were prepared by sulfuric acid-catalyzed, ringopening equilibration with the end-capping agents hexamethyldisiloxane (MM), divinyltetramethyldisiloxane (M V M V ), and tetramethyldisiloxane (M H M H ), respectively. The molecular weights of the polymers were controlled by adjusting the ratio of monomer to end-capping agent. All of these polymers are oils and exhibit molecular weight-dependent viscosities that are qualitatively similar to those of polydimethylsiloxane (PDMS)-based analogs prepared by the same reaction using octamethylcyclotetrasiloxane (D 4 ) instead of c-M 2 E. Vinyl end-capped polymers with a range of molecular weights were cross-linked by platinum-catalyzed hydrosilylation with tetramethylcyclotetrasiloxane (D H 4 ) to prepare a series of transparent solid elastomers with moduli that increase with decreasing molecular weight. These studies suggest that reactive polymers prepared from c-M 2 E may be useful resins in two-part curable elastomer formulations. Several experiments, as well as the over 60-year-old initial synthesis of this polymer, suggest that the recyclability of these resins and elastomers may be practical.

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Polymeric Advancements in Transdermal Drug Delivery: A Comprehensive Review on Stability, Safety, and Biocompatibility

Raghav,

Rastogi,

Chandra

et al. 2024

Macromolecular Symposia

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Transdermal drug delivery systems have received a lot of attention due to their noninvasive nature and possible advantages over standard drug administration methods. Because transdermal administration systems skip the gastrointestinal tract and hence avoid hepatic first pass metabolism, also the chance of adverse effects such as liver malfunction and gastrointestinal tract discomfort is low. This comprehensive review explores the various aspects of polymeric advancements in transdermal drug delivery, encompassing their roles as matrix and microreservoir formers, microneedles, pressure sensitive adhesives, rate controlling membranes, and many other components. The article emphasizes the importance of biocompatibility, chemical compatibility, and stability of polymers within the transdermal delivery system. Furthermore, it delves into the recent advancements in synthetic and natural polymer‐based transdermal drug delivery systems. Thus, a comprehensive search strategy is conducted in electronic databases such as PubMed, Scopus, and Web of Science to write this review paper. The scope of this investigation involves an in‐depth study of the various polymeric materials used, their formulations, and the mechanisms that support their efficacy in delivering medications over the skin barrier. Additionally, it explores the challenges associated with stability and safety concerns, while highlighting novel approaches to overcome these problems. Furthermore, the review discusses the biocompatibility of polymeric materials, crucial for ensuring minimal adverse effects and maximum therapeutic efficacy.

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A transformable and biocompatible polymer series using ring-opening polymerization of cyclic silane for more effective transdermal drug delivery

Cited by 7 publications

References 40 publications

Key Transdermal Patch Using Cannabidiol-Loaded Nanocarriers with Better Pharmacokinetics in vivo

Key Transdermal Patch Using Cannabidiol-Loaded Nanocarriers with Better Pharmacokinetics in vivo

Hemisilicone Elastomers That Are Recyclable to the Monomer

Polymeric Advancements in Transdermal Drug Delivery: A Comprehensive Review on Stability, Safety, and Biocompatibility

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