A transistor-like pH-sensitive nanodetergent for selective cancer therapy

Liu, Mingdong; Huang, Liangqi; Zhang, Weinan; Wang, Xiaochuan; Geng, Yuanyuan; Zhang, Yuhao; Wang, Li; Zhang, Wenbin; Zhang, Yunjiao; Xiao, Shiyan; Bao, Yan; Xiong, Menghua; Wang, Jun

doi:10.1038/s41565-022-01085-5

Cited by 84 publications

(71 citation statements)

References 35 publications

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“…This phenomenon could be the result of pore formation in cell membrane after the antibacterial combination treatment and a subsequent release of intracellular substances. [ 57‐58 ]…”

Section: Resultsmentioning

confidence: 99%

Synergistic Combination of Biodegradable Peptide Polymer and Curcumin as Promising Antibiotic Substitution in Aquaculture to Alleviate the Global Challenge of Antimicrobial Resistance

Chen

Shao

et al. 2022

Chin. J. Chem.

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Comprehensive Summary The massive use of antibiotics in aquaculture and resulted antibacterial resistance problem urgently need antibiotic substitutions. Herein, we report a promising substitution of aquaculture antibiotics using a synergistic combination of biodegradable peptide polymers and curcumin, a natural compound from plant. The synergistic combination shows strong antibacterial activity against V. fluvialis and some other common bacteria in aquaculture. The membrane‐damaging antibacterial mechanism echoes our finding that the synergistic combination will not induce bacteria to develop resistance after continuous use. The synergistic combination also displays effective cure on V. fluvialis‐infected zebrafish. The biodegradability of the peptide polymer enables the combination to lose antibacterial activity and will not cause selective pressure on bacterial in the environment. Our study indicates potential application of synergistic composition, biodegradable peptide polymer and curcumin, as promising antibiotic substitution in aquaculture, which represents a promising strategy to address the global challenge of antimicrobial resistance.

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“…This phenomenon could be the result of pore formation in cell membrane after the antibacterial combination treatment and a subsequent release of intracellular substances. [ 57‐58 ]…”

Section: Resultsmentioning

confidence: 99%

Synergistic Combination of Biodegradable Peptide Polymer and Curcumin as Promising Antibiotic Substitution in Aquaculture to Alleviate the Global Challenge of Antimicrobial Resistance

Chen

Shao

et al. 2022

Chin. J. Chem.

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“…193 The differences in extracellular and intracellular pH between cancer and healthy cells can be used to develop pH-sensitive polymer nanomaterials to rupture the plasma membrane of cancer cells. 194 Liu et al developed polymer nanomaterials that exhibited potent membranolytic activity and could selectively destroy the plasma membrane of cancer cells while these pH-sensitive polymer nanomaterials showed low toxicity to healthy cells. 194…”

Section: Extracellular and Intracellular Phmentioning

confidence: 99%

“…194 Liu et al developed polymer nanomaterials that exhibited potent membranolytic activity and could selectively destroy the plasma membrane of cancer cells while these pH-sensitive polymer nanomaterials showed low toxicity to healthy cells. 194…”

Section: Extracellular and Intracellular Phmentioning

confidence: 99%

How can we use the endocytosis pathways to design nanoparticle drug-delivery vehicles to target cancer cells over healthy cells?

et al. 2022

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“…Targeting the tumor involves the use of ligands specific to tumor cells or tumor microenvironments. Many of the common targeting ligands have sensitivity to pH 27 , enzyme reactivity 25 , temperature 28 , and other biomarkers.…”

Section: Tumor Targeting and Extravasationmentioning

confidence: 99%