A Transparent, Tough and Self-Healable Biopolymeric Composites Hydrogel for Open Wound Management

Abstract

Modern healthcare engineering requires a wound dressing solution supported by materials with outstanding features such as high biological compatibility, strong mechanical strength, and higher transparency with effective antibacterial properties. Here, we present a unique hydrogel technology consisting of two negatively charged biopolymers and a positively charged synthetic polymer. The interaction between charged polymers through hydrogen bonds has been created, which are revealed in the simulation by density functional theory and Fourier transform infrared spectra of individual polymers and the hydrogel film. The transparent hydrogel film dressings showed excellent stretchability, a higher water swelling ratio (60%), and strong mechanical strength (∼100 MPa) with self-healing abilities (85−90%). The fabricated hydrogel film showed stable blood clots (within 119 ± 15 s) with rapid hemostasis (<2%) properties and effective antibacterial studies against E. coli and S. aureus bacterial strains. In addition, the obtained hydrogel film also showed excellent cell viability on mouse fibroblast cells. With their enormous amenability to modification, these hydrogel films may serve as promising biomaterials for wound dressing applications.

Multifunctional Ionic Hydrogel-Based Transdermal Delivery of 5-Fluorouracil for the Breast Cancer Treatment

“…This thixotropic behavior suggests that the present ionic hydrogels are self-healable without external stimuli. This is due to breaking and reforming of noncovalent interactions between IL and OA . Likewise, the self-healing property of l -phenylalanine and β-amninoisobutyric acid-based hydrogel was also explored by the relaxation test, which was measured G′ and G″ at lower strain 0.1% and higher strain 50% stain value …”

“…This is due to breaking and reforming of noncovalent interactions between IL and OA. 39 Likewise, the self-healing property of L-phenylalanine and β-amninoisobutyric acid-based hydrogel was also explored by the relaxation test, which was measured G′ and G″ at lower strain 0.1% and higher strain 50% stain value. 40 Adhesive behavior is crucial for the TDDSs, as the contact time with the skin significantly affects drug penetration.…”

Green, pH-Sensitive, Highly Stretchable, and Hydrogen Bond-Dominated Ionogel for Wound Healing Activity

“…Wound dressings have always been one of the important branches in the field of biomedicine. − In recent years, hydrogels have become one of the ideal candidates for wound dressings due to their excellent biocompatibility and controllable physical properties. − For example, Shi et al fabricated a self-healing and injectable hydrogel dressing to apply low-temperature photothermal therapy on antisepsis with high efficiency . Zhang et al prepared a transparent and antibacterial carboxymethyl cellulose/sodium alginate/PVA hydrogel film for open wound management . Li et al presented a multifunctional colorimetric hydrogel dressing for wound antibacterial and pH detection .…”