A transverse intrafascicular multichannel electrode (TIME) to interface with the peripheral nerve

Boretius, Tim; Badía, Jordi; Pascual‐Font, Arán; Schüettler, Martin; Navarro, Xavier; Yoshida, Ken; Stieglitz, Thomas

doi:10.1016/j.bios.2010.05.010

Cited by 409 publications

(317 citation statements)

References 40 publications

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“…The pelvic nerve is a promising stimulation target for the control of bladder function as it provides autonomic efferent inputs to contract the bladder detrusor muscle, and is anatomically and functionally more specific for bladder neuromodulation 19, 28, 29. However, the pelvic nerve is a small visceral nerve located deep within the body, which leads to difficulties in implantation, as well as maintaining contact for reliable stimulation if current neural electrodes are used 6, 12, 13, 30. We successfully performed stimulation of the pelvic nerves using a miniature FNC to control bladder function while monitoring bladder pressure ( Figure 3 a).…”

Section: Resultsmentioning

confidence: 99%

Toward Bioelectronic Medicine—Neuromodulation of Small Peripheral Nerves Using Flexible Neural Clip

et al. 2017

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Neural modulation technology and the capability to affect organ function have spawned the new field of bioelectronic medicine. Therapeutic interventions depend on wireless bioelectronic neural interfaces that can conformally and easily attach to small (few hundred micrometers) nerves located deep in the body without neural damage. Besides size, factors like flexibility and compliance to attach and adapt to visceral nerves associated moving organs are of paramount importance and have not been previously addressed. This study proposes a novel flexible neural clip (FNC) that can be used to interface with a variety of different peripheral nerves. To illustrate the flexibility of the design, this study stimulates the pelvic nerve, the vagus nerve, and branches of the sciatic nerve and evaluates the feasibility of the design in modulating the function of each of these nerves. It is found that this FNC allows fine‐tuning of physiological processes such as micturition, heart rate, and muscle contractions. Furthermore, this study also tests the ability of wirelessly powered FNC to enable remote modulation of visceral pelvic nerves located deep in the body. These results show that the FNC can be used with a range of different nerves, providing one of the critical pieces in the field of bioelectronics medicines.

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Section: Resultsmentioning

confidence: 99%

Toward Bioelectronic Medicine—Neuromodulation of Small Peripheral Nerves Using Flexible Neural Clip

et al. 2017

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“…Specifically, TIME was developed to manage phantom limb pain in patients who required simultaneous excitation of multiple parallel fascicles within a nerve. This feat previously required the implantation of multiple LIFEs [14].…”

Section: Longitudinal and Transverse Intrafascicular Electrodementioning

confidence: 99%

“…Transverse intrafascicular multi-channel electrodes (TIMEs) provide superior spatial selectivity than LIFE by enabling contact beyond one fascicle (Fig. 3) [14]. Specifically, TIME was developed to manage phantom limb pain in patients who required simultaneous excitation of multiple parallel fascicles within a nerve.…”

Section: Longitudinal and Transverse Intrafascicular Electrodementioning

confidence: 99%

Interfacing with the nervous system: a review of current bioelectric technologies

et al. 2017

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The aim of this study is to discuss the state of the art with regard to established or promising bioelectric therapies meant to alter or control neurologic function. We present recent reports on bioelectric technologies that interface with the nervous system at three potential sites-(1) the end organ, (2) the peripheral nervous system, and (3) the central nervous system-while exploring practical and clinical considerations.

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“…For our target application, we believe that sub-fascicular level selectivity will be required and as such we are expecting to use micro-electrode arrays or intra-fascicular devices such as the TIME electrodes [20]. These electrodes are usually modelled as a resistor in series with a parallel resistor and capacitor (see Fig.…”

Section: A Energy Efficiencymentioning

confidence: 99%

An energy-efficient, dynamic voltage scaling neural stimulator for a proprioceptive prosthesis

Williams

Constandinou

2012

2012 IEEE International Symposium on Circuits and Systems

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Abstract-This paper presents an 8 channel energy-efficient neural stimulator for generating charge-balanced asymmetric pulses. Power consumption is reduced by implementing a fullyintegrated DC-DC converter that uses a reconfigurable switched capacitor topology to provide 4 output voltages for Dynamic Voltage Scaling (DVS). DC conversion efficiencies of up to 82 % are achieved using integrated capacitances of under 1 nF and the DVS approach offers power savings of up to 50 % compared to the front end of a typical current controlled neural stimulator. A novel charge balancing method is implemented which has a low level of accuracy on a single pulse and a much higher accuracy over a series of pulses. The method used is robust to process and component variation and does not require any initial or ongoing calibration. Measured results indicate that the charge imbalance is typically between 0.05 % -0.15 % of charge injected for a series of pulses. Ex-vivo experiments demonstrate the viability in using this circuit for neural activation. The circuit has been implemented in a commercially-available 0.18 μm HV CMOS technology and occupies a core die area of approximately 2.8 mm 2 for an 8 channel implementation.

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A transverse intrafascicular multichannel electrode (TIME) to interface with the peripheral nerve

Cited by 409 publications

References 40 publications

Toward Bioelectronic Medicine—Neuromodulation of Small Peripheral Nerves Using Flexible Neural Clip

Toward Bioelectronic Medicine—Neuromodulation of Small Peripheral Nerves Using Flexible Neural Clip

Interfacing with the nervous system: a review of current bioelectric technologies

An energy-efficient, dynamic voltage scaling neural stimulator for a proprioceptive prosthesis

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