A trespasser from a foreign land? A case report of primary mucosal leishmaniasis

Fleissig, Yoram; Dan-Gur, Mary; Michael-Gayego, Ayelet; Maly, Alexander; Tabib, Rami; Jaffe, Charles L.; Korem, Maya

doi:10.1186/s12879-022-07169-w

Cited by 3 publications

(2 citation statements)

References 9 publications

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“… 6 In a few instances, mucocutaneous forms are found to be more severe than others and are usually chronic and often occur years after the presentation of skin lesions. 7 , 13 It can also cause severe respiratory complications including the destruction of lung tissue. Malnutrition is common in leishmaniasis, thus good nutrition is important to prevent remission of the disease.…”

Section: Introductionmentioning

confidence: 99%

“…The disease can occur in different clinical forms such as cutaneous, mucosal, and visceral 6 . In a few instances, mucocutaneous forms are found to be more severe than others and are usually chronic and often occur years after the presentation of skin lesions 7,13 . It can also cause severe respiratory complications including the destruction of lung tissue.…”

Section: Introductionmentioning

confidence: 99%

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Oral mucosal leishmaniasis presenting as a nonhealing chronic oral growth: A case report

Bajgai¹,

Tshering²,

Pradhan³

et al. 2023

Clinical Case Reports

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oral mucosal leishmaniasis presenting as a nonhealing chronic oral growth: A case report

Bajgai¹,

Tshering²,

Pradhan³

et al. 2023

Clinical Case Reports

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Leishmaniasis Diagnosed in the United States Successfully Treated With Miltefosine

LaRocque,

Zheng,

Khambaty

et al. 2024

Infect Dis Clin Pract

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Leishmaniasis is an infectious disease caused by the parasitic protozoa species Leishmania and is most often transmitted to humans through the bite of a sandfly. The most common manifestation is a cutaneous lesion. Leishmaniasis is endemic to many countries throughout the world but rarely diagnosed in the United States. Here, we report a 64-year-old man with initially undisclosed recent travel to Sudan, an endemic country, who returned to the United States with cutaneous lesions on his forehead and dorsal hand. After failing initial therapy, a biopsy showed amastigotes (the tissue stage of the parasite), chronic inflammation with numerous plasma cells, granulomatous features, focal necrobiosis, and neutrophilic debris, consistent with leishmaniasis. The lesions did not significantly improve with fluconazole, but miltefosine (100–200 mg daily) resulted in remission over an 8-week course. The purpose of this case report is to highlight the importance of including rare infectious organisms in the differential and briefly discuss diagnostic and treatment methods.

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Mucosal leishmaniasis of the lips and cheeks: a first concomitant presentation of visceral and mucosal leishmaniasis in a patient living with HIV/AIDS in Monastir, Tunisia

Berrezouga,

Kooli,

Belgacem

et al. 2024

AIDS Res Ther

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Background Visceral Leishmaniasis (VL) is the most severe and fatal disease if left untreated. In people living with HIV/AIDS (PLHA), VL is considered an emerging opportunistic infection. The aim of this manuscript was to report a first case in Tunisia of a concomitant presentation of visceral and oral leishmaniasis in a patient LHA. A systematic review of the literature was performed according to PRISMA guidelines, as well. Case presentation The patient, a 43-year-old heterosexual man, treated for HIV/AIDS was referred for macrocheilitis of the upper and lower lips. A noticeable nodular and painless swelling extending to the cheeks’ mucosa was noted. The patient's poor oral hygiene was evident due to the presence of multiple dental caries. Histological analysis of the biopsied lower lip sample revealed the presence of numerous Leishmania amastigotes. The diagnosis of VL was clinically confirmed by the presence of a mild splenomegaly and pancytopenia and biologically by the identification of the parasite using PCR Lei and the species L. infantum involved using RFLP-PCR and culture. The treatment consisted of an intravenous administration of liposomal Amphotericin B (Ambisome®, 40 mg/kg/weight) for a period of 6 weeks. A favorable outcome was noted after one year with the resolution of clinical symptoms and a negative Leishmania blood PCR test. After 2 years, the patient remained asymptomatic but showed a positive Leishmania blood PCR test. Dolutegravir® was introduced in the patient’s ART regimen. Conclusions To the best of our knowledge, this is the first case report in Tunisia of atypical VL diagnosed through an uncommon oral location in an HIV/AIDS co-infected patient . Since VL is a severe and potentially fatal disease, it is essential for dentists to perform a thorough clinical examination and adopt a multidisciplinary approach in order to ensure an early diagnosis and an effective treatment outcome. Supplementary Information The online version contains supplementary material available at 10.1186/s12981-024-00660-1.

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A trespasser from a foreign land? A case report of primary mucosal leishmaniasis

Cited by 3 publications

References 9 publications

Oral mucosal leishmaniasis presenting as a nonhealing chronic oral growth: A case report

Oral mucosal leishmaniasis presenting as a nonhealing chronic oral growth: A case report

Leishmaniasis Diagnosed in the United States Successfully Treated With Miltefosine

Mucosal leishmaniasis of the lips and cheeks: a first concomitant presentation of visceral and mucosal leishmaniasis in a patient living with HIV/AIDS in Monastir, Tunisia

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