A Triterpene Ozonide from Senecio selloi

Ruecker, G.; Manns, Detlef; Schenkel, Eloir Paulo; Hartmann, Rudolf; Heinzmann, Berta Maria

doi:10.1002/chin.200346187

Cited by 2 publications

(3 citation statements)

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“…Two triterpenes, called gilvanol ( 138 ) and 3-deoxydilvanol ( 139 ), have been detected in the extracts of the red-bark oak, Quercus gilva [ 170 , 223 ]. An interesting endoperoxide, adian-5-ene ozonide ( 140 ) was found in the fern leaves of Adiantum monochlamys (Pteridaceae) and Oleandra wallichii (Davalliaceae), and another peroxide, a triterpene ozonide ( 141 ), was detected in the root extract of Senecio selloi [ 224 , 225 ].…”

Section: Polycyclic Endoperoxides Derived From Plants and Liverwormentioning

confidence: 99%

Antiprotozoal and Antitumor Activity of Natural Polycyclic Endoperoxides: Origin, Structures and Biological Activity

et al. 2021

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Polycyclic endoperoxides are rare natural metabolites found and isolated in plants, fungi, and marine invertebrates. The purpose of this review is a comparative analysis of the pharmacological potential of these natural products. According to PASS (Prediction of Activity Spectra for Substances) estimates, they are more likely to exhibit antiprotozoal and antitumor properties. Some of them are now widely used in clinical medicine. All polycyclic endoperoxides presented in this article demonstrate antiprotozoal activity and can be divided into three groups. The third group includes endoperoxides, which show weak antiprotozoal activity with a reliability of up to 70%, and this group includes only 1.1% of metabolites. The second group includes the largest number of endoperoxides, which are 65% and show average antiprotozoal activity with a confidence level of 70 to 90%. Lastly, the third group includes endoperoxides, which are 33.9% and show strong antiprotozoal activity with a confidence level of 90 to 99.6%. Interestingly, artemisinin and its analogs show strong antiprotozoal activity with 79 to 99.6% confidence against obligate intracellular parasites which belong to the genera Plasmodium, Toxoplasma, Leishmania, and Coccidia. In addition to antiprotozoal activities, polycyclic endoperoxides show antitumor activity in the proportion: 4.6% show weak activity with a reliability of up to 70%, 65.6% show an average activity with a reliability of 70 to 90%, and 29.8% show strong activity with a reliability of 90 to 98.3%. It should also be noted that some polycyclic endoperoxides, in addition to antiprotozoal and antitumor properties, show other strong activities with a confidence level of 90 to 97%. These include antifungal activity against the genera Aspergillus, Candida, and Cryptococcus, as well as anti-inflammatory activity. This review provides insights on further utilization of polycyclic endoperoxides by medicinal chemists, pharmacologists, and the pharmaceutical industry.

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Section: Polycyclic Endoperoxides Derived From Plants and Liverwormentioning

confidence: 99%

Antiprotozoal and Antitumor Activity of Natural Polycyclic Endoperoxides: Origin, Structures and Biological Activity

et al. 2021

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“…They often play a crucial role in the defense against microorganisms (Siqui et al, 2000). The essential oils have been used for bactericidal, virucidal, fungicidal, antiparasitic, insecticidal, medicinal and cosmetic applications, yet in pharmaceutical, sanitary, cosmetic, agricultural and food industries (Bakkali et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…For this species, the literature describes peroxides with sesquiterpenic structure (Rücker et al, 1996;Heinzmann, 1996) as well as triterpenoids (Rücker et al, 1999;Heinzmann, 1996;Rücker et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Composition and evaluation of the antimicrobial activity of the essential oil of Senecio selloi Spreng DC.

Silva

Spader

Alves

et al. 2013

Rev. bras. plantas med.

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ABSTRACT:The essential oil of the aerial parts of Senecio selloi Spreng. DC. was extracted by hydrodistillation and analyzed by GC/MS. Nineteen compounds were identified, representing 99.9% of the total. The main compounds were found to be sesquiterpene hydrocarbons (71.3%), most of them with a bisabolane skeleton (59.4%). The major constituent was α-zingiberene (54%), followed by monoterpene α-isolimonene (16%). The essential oil was also tested against two Gram-positive and two Gram-negative bacterial species, three yeasts, and an algae. From the strains assayed, only Bacillus subtilis ATCC 6633 showed susceptibility (MIC and MBC = 4400 µg/mL) to the essential oil.Key words: Antimicrobial activity, essential oil, Senecio selloi Spreng. DC. RESuMo: Composição e avaliação da atividade antimicrobiana do óleo essencial deSenecio selloi Spreng DC. O óleo essencial das partes aéreas de Senecio selloi Spreng DC. foi extraído por hidrodestilação e analisado por CG/EM. Dezenove constituintes foram identificados, representando 99,9% do total. Os principais compostos fornecidos foram sesquiterpenos hidrocarbonetos (71,3%), a maioria destes com esqueleto bisabolano (59,4%). O constituinte majoritário foi a-zingibereno (54%), seguido do monoterpeno a-isolimoneno (16%). O óleo essencial foi testado contra duas cepas Gram-positivas e duas Gram-negativas, três fungos e uma alga. De todas as linhagens testadas somente Bacillus subtilis ATCC 6633 mostrou suscetibilidade (CIM e CBM = 4400 µg/mL) para o óleo essencial. Palavras-chave:Atividade antimicrobiana, óleo essencial, Senecio selloi Spreng. DC.Recebido para publicação em 27

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A Triterpene Ozonide from Senecio selloi

Abstract: Terpenes Terpenes U 0200 A Triterpene Ozonide from Senecio selloi -[isolation, structure elucidation and antiplasmodial activity of the new triterpene ozonide (I)]. -(RUECKER*, G.; MANNS, D.; SCHENKEL, E. P.; HARTMANN, R.; HEINZMANN, B. M.; Arch.

Cited by 2 publications

References 1 publication

Antiprotozoal and Antitumor Activity of Natural Polycyclic Endoperoxides: Origin, Structures and Biological Activity

Antiprotozoal and Antitumor Activity of Natural Polycyclic Endoperoxides: Origin, Structures and Biological Activity

Composition and evaluation of the antimicrobial activity of the essential oil of Senecio selloi Spreng DC.

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