A tumor-microenvironment fully responsive nano-platform for MRI-guided photodynamic and photothermal synergistic therapy

Wang, Daquan; Zhang, Ning; Jing, Xunan; Zhang, Yun; Xu, Yanzi; Meng, Lingjie

doi:10.1039/d0tb01373k

Cited by 35 publications

(20 citation statements)

References 46 publications

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“…[13] Furthermore, their ability to get dissociated into nontoxic Mn 2+ ions in the presence of H 2 O 2 and GSH, can enhance their biological clearance and avoid non-specific systemic toxicity. [14] Previous studies have reported the photothermal properties of MnO 2 based nanoparticles. [15,16] Jin Liu et al, has developed enzymatically synthesized MnO 2 nanoparticles for photothermal therapy as well MRI imaging.…”

Section: Introductionmentioning

confidence: 99%

Heat‐Confined Tumor‐Docking Reversible Thermogel Potentiates Systemic Antitumor Immune Response During Near‐Infrared Photothermal Ablation in Triple‐Negative Breast Cancer

Revuri

Rajendrakumar

Park

et al. 2021

Adv Healthcare Materials

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Triple-negative breast cancer (TNBC) features immunologically "cold" tumor microenvironments with limited cytotoxic T lymphocyte (CTL) infiltration. Although ablation therapies have demonstrated modulation of "cold" TNBC tumors to inflamed "hot" tumors, recruitment of myeloid derived suppressor cells (MDSCs) at the tumors post ablation therapies prevents the infiltration of CTLs and challenge the antitumor potentials of T-cell therapies. Here, a thermal ablation immunotherapy strategy is developed to prevent the immune suppressive effects of MDSCs during photothermal ablation and induce a durable systemic antitumor immunity to eradicate TNBC tumors. An injectable pluronic F127/hyaluronic acid (HA)-based hydrogel embedded with manganese dioxide (BM) nanoparticles and TLR7 agonist resiquimod (R848) (BAGEL-R848), is synthesized to induce in situ laser-assisted gelation of the hydrogel and achieve desired ablation temperatures at a low laser-exposure time. Upon 808-nm laser irradiation, a significant reduction in the tumor burden is observed in BAGEL-R848-injected 4T1 tumor-bearing mice. The ablation induced immunogenic cell death and sustained release of R848 from BAGEL-R848 promotes dendritic cell maturation and reduced MDSCs localization in tumors. In addition, inflammatory M1 macrophages and CD8+IFN+ CTL are enriched in distant tumors in bilateral 4T1 tumor model, preventing metastatic tumor growth and signifying the potential of BAGEL-R848 to treat TNBC.

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Section: Introductionmentioning

confidence: 99%

Heat‐Confined Tumor‐Docking Reversible Thermogel Potentiates Systemic Antitumor Immune Response During Near‐Infrared Photothermal Ablation in Triple‐Negative Breast Cancer

Revuri

Rajendrakumar

Park

et al. 2021

Adv Healthcare Materials

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“…Unfortunately, oxygen-dependent PDT was severely discouraged due to the low intratumoral oxygen level [ 100 – 102 ]. Fortunately, nanozymes with catalase-like activities could provide a feasible method to improve tumor oxygen-involved therapeutic methods [ 103 , 104 ]. Based on the catalase-like activity, platinum (Pt) based nanomaterials have been widely applied to decompose the endogenous H 2 O 2 to O 2 , thus relieving tumor hypoxia for tumor therapy, including PDT and radiotherapy [ 105 , 106 ].…”

Section: Platinum-based Nanozymesmentioning

confidence: 99%

Nanozymes-recent development and biomedical applications

et al. 2022

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Nanozyme is a series of nanomaterials with enzyme-mimetic activities that can proceed with the catalytic reactions of natural enzymes. In the field of biomedicine, nanozymes are capturing tremendous attention due to their high stability and low cost. Enzyme-mimetic activities of nanozymes can be regulated by multiple factors, such as the chemical state of metal ion, pH, hydrogen peroxide (H2O2), and glutathione (GSH) level, presenting great promise for biomedical applications. Over the past decade, multi-functional nanozymes have been developed for various biomedical applications. To promote the understandings of nanozymes and the development of novel and multifunctional nanozymes, we herein provide a comprehensive review of the nanozymes and their applications in the biomedical field. Nanozymes with versatile enzyme-like properties are briefly overviewed, and their mechanism and application are discussed to provide understandings for future research. Finally, underlying challenges and prospects of nanozymes in the biomedical frontier are discussed in this review. Graphical Abstract

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“…Wang et al . constructed MWNTs-based nanosystem for MRI-guided and TME-responsive phototherapy [ 139 ]. A uniform MnO 2 layer and photosensitizer Ce6 were modified on MWNTs for enhanced phototherapy.…”

Section: Carbon Nanotubes In Cancer Treatmentmentioning

confidence: 99%

Insights on functionalized carbon nanotubes for cancer theranostics

et al. 2021

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Despite the exciting breakthroughs in medical technology, cancer still accounts for one of the principle triggers of death and conventional therapeutic modalities often fail to attain an effective cure. Recently, nanobiotechnology has made huge advancement in cancer therapy with gigantic application potential because of their ability in achieving precise and controlled drug release, elevating drug solubility and reducing adverse effects. Carbon nanotubes (CNTs), one of the most promising carbon-related nanomaterials, have already achieved much success in biomedical field. Due to their excellent optical property, thermal and electronic conductivity, easy functionalization ability and high drug loading capacity, CNTs can be applied in a multifunctional way for cancer treatment and diagnosis. In this review, we will give an overview of the recent progress of CNT-based drug delivery systems in cancer theranostics, which emphasizes their targetability to intracellular components of tumor cells and extracellular elements in tumor microenvironment. Moreover, a detailed introduction on how CNTs penetrate inside the tumor cells to reach their sites of action and achieve the therapeutic effects, as well as their diagnostic applications will be highlighted. Graphic Abstract

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A tumor-microenvironment fully responsive nano-platform for MRI-guided photodynamic and photothermal synergistic therapy

Cited by 35 publications

References 46 publications

Heat‐Confined Tumor‐Docking Reversible Thermogel Potentiates Systemic Antitumor Immune Response During Near‐Infrared Photothermal Ablation in Triple‐Negative Breast Cancer

Heat‐Confined Tumor‐Docking Reversible Thermogel Potentiates Systemic Antitumor Immune Response During Near‐Infrared Photothermal Ablation in Triple‐Negative Breast Cancer

Nanozymes-recent development and biomedical applications

Insights on functionalized carbon nanotubes for cancer theranostics

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