A Tumor Microenvironment-Triggered and Photothermal-Enhanced Nanocatalysis Multimodal Therapy Platform for Precise Cancer Therapy

Qiao, Lei; Sun, Yujie; Yao, Hang; Fan, Jingjing; Wang, Zhongxue; Wu, Ping; Cai, Chenxin

doi:10.1021/acs.chemmater.1c03169

Cited by 16 publications

(11 citation statements)

References 67 publications

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“…The analyses reveal that there are subtopics such as “photothermal therapy”, “antibacterial activity”, “lipid membranes”, “virus entry”, “amyloid structure”, “nanopores”, and “DNA nanostructures”. Most of publications in the biocompatible materials topic belong to the “photothermal therapy” topic, which includes photothermal therapies for nanoparticle platforms, , photodynamic therapies for nanoparticle formulations, nanoparticle-based imaging and therapeutic agents, and nanotheranostics and cancer therapy . We note that a cluster of interest can be classified into several subfields by applying our reproducible approach again to the set of documents belonging to the topic.…”

Section: Resultsmentioning

confidence: 99%

Quantitative Topic Analysis of Materials Science Literature Using Natural Language Processing

Choi,

Lee

2023

ACS Appl. Mater. Interfaces

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Materials science research has garnered extensive attention from industry, society, policy, and academia. However, understanding the research landscape and extracting strategic insights are challenging due to the increasing diversity and volume of publications. This study proposes a natural language processingbased protocol for extracting text-encoded topics from a large volume of scientific literature, uncovering research interests of scientific communities, as well as convergence trends. We report a topic map, representing the materials science research landscape with text-mined 257 topics regarding biocompatible materials, structural materials, electrochemistry, or photonics. We analyze the topic map in terms of national research interests in materials science, revealing competitive positions and strategies of active nations. For example, it is found that the increasing trend of research interest in machine learning topic was captured in the United States earlier than other nations. Similarly, our journal-level analyses serve as reference information for journal recommendations and trend guidance, showing that the main topics and research interests of materials science journals slightly changed over time. Moreover, we build the topic association network which can highlight the status and future potential of interdisciplinary research, revealing research fields with high centrality in the network such as machine learning-enabled composite modeling, energy policy, or wearable electronics. This study offers insightful results on current and nearfuture materials science research landscapes, facilitating the understanding of stakeholders, amidst the fast-evolving and diverse knowledge of materials science.

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Section: Resultsmentioning

confidence: 99%

Quantitative Topic Analysis of Materials Science Literature Using Natural Language Processing

Choi,

Lee

2023

ACS Appl. Mater. Interfaces

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“…These data revealed that the magnetomechanical and antineoplastic effects were considerably boosted due to the higher intracellular concentration of ZNWs, which can be attributed to the specific targeting of ZNWs. Consequently, the addition of adhesion molecules derived from the cancer cell membranes to a therapeutic platform is favorable owing to the increased specificity, which results in fewer side effects and the increased effectiveness of the treatment. − …”

Section: Resultsmentioning

confidence: 99%

Iron Nanowires Coated with Metal–Organic Frameworks for Cell-Type-Specific Multimodal Therapy

Alyami

Patel

et al. 2022

ACS Appl. Nano Mater.

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Targeted therapy has the potential to revolutionize medical approaches to bring us closer to an effective personalized therapy model. In this work, we developed homologous-targeted magnetic nanowires coated with biologics-loaded zeolitic imidazolate frameworks and cellular membranes (ZNWs) to provide an increased therapeutic potential both in vitro and in vivo. In vitro, the uncoated ZNWs combined with laser treatment reduced cancer cell viability by 34.6%, whereas the coated ZNWs combined with laser treatment reduced cancer cell viability by 45.91%. In vivo, ZNWs accumulated selectively in MCF-7 cancer cells and maintained a high intensity for up to 120 h, which reduced tumor growth significantly. Combining gene and tumor ablation treatment with the homologous targeting ability of ZNWs resulted in about 73% cell death. We believe that using such an assembled coating to camouflage delivery vehicles has effective outcomes in terms of improved targeting and therapeutic efficiency and should be studied further for medical translation.

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“…49 As shown in Figure S19, the generation of •OH was confirmed by the absorption peak at 652 nm in the group FTEP-TBFc + H 2 O 2 . Moreover, the absorption peak increased even after the addition of reducing GSH due to the promoted Fenton reaction by the yielded H 2 S. 50 Remarkably, the peak intensity was further enhanced when exposed to laser irradiation, meaning the laser-enhanced generation of •OH. increased and peaked at 5 h. A fluorescent turn-on probe, 2,7dichloro-dihydro-fluorescein diacetate (DCFH-DA), 51 was employed to evaluate the intracellular ROS level generated by FTEP-TBFc NPs.…”

Section: ■ Introductionmentioning

confidence: 98%

Tumor Microenvironment-Responsive One-for-All Molecular-Engineered Nanoplatform Enables NIR-II Fluorescence Imaging-Guided Combinational Cancer Therapy

Wu,

Liu,

et al. 2023

Anal. Chem.

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The activable NIR-based phototheranostic nanoplatform (NP) is considered an efficient and reliable tumor treatment due to its strong targeting ability, flexible controllability, minimal side effects, and ideal therapeutic effect. This work describes the rational design of a second near-infrared (NIR-II) fluorescence imaging-guided organic phototheranostic NP (FTEP-TBFc NP). The molecular-engineered phototheranostic NP has a sensitive response to glutathione (GSH), generating hydrogen sulfide (H 2 S) gas, and delivering ferrocene molecules in the tumor microenvironment (TME). Under 808 nm irradiation, FTEP-TBFc could not only simultaneously generate fluorescence, heat, and singlet oxygen but also greatly enhance the generation of reactive oxygen species to improve chemodynamic therapy (CDT) and photodynamic therapy (PDT) at a biosafe laser power of 0.33 W/cm 2 . H 2 S inhibits the activity of catalase and cytochrome c oxidase (COX IV) to cause the enhancement of CDT and hypothermal photothermal therapy (HPTT). Moreover, the decreased intracellular GSH concentration further increases CDT's efficacy and downregulates glutathione peroxidase 4 (GPX4) for the accumulation of lipid hydroperoxides, thus causing the ferroptosis process. Collectively, FTEP-TBFc NPs show great potential as a versatile and efficient NP for specific tumor imaging-guided multimodal cancer therapy. This unique strategy provides new perspectives and methods for designing and applying activable biomedical phototheranostics.

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A Tumor Microenvironment-Triggered and Photothermal-Enhanced Nanocatalysis Multimodal Therapy Platform for Precise Cancer Therapy

Cited by 16 publications

References 67 publications

Quantitative Topic Analysis of Materials Science Literature Using Natural Language Processing

Quantitative Topic Analysis of Materials Science Literature Using Natural Language Processing

Iron Nanowires Coated with Metal–Organic Frameworks for Cell-Type-Specific Multimodal Therapy

Tumor Microenvironment-Responsive One-for-All Molecular-Engineered Nanoplatform Enables NIR-II Fluorescence Imaging-Guided Combinational Cancer Therapy

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