A tumorigenic cell line derived from a hamster cholangiocarcinoma associated with Opisthorchis felineus liver fluke infection

Similarities and differences among the Opisthorchiidae liver flukes: insights from Opisthorchis felineus

“…Hamsters infected with O. felineus and treated with low doses of a carcinogenic nitrosamine (dimethylnitrosamine) develop CCA tumours (Fig. 2G) (Maksimova et al ., 2017; Mordvinov et al ., 2021): the conditions under which tumours also develop under the influence of O. viverrini or C. sinensis (Boonmars et al ., 2009; Sripa et al ., 2012 a ). The morphology and histological markers of O. felineus -promoted tumours fully match the characteristics of the CCA associated with O. viverrini or C. sinensis (Maksimova et al ., 2017; Kovner et al ., 2019; Na et al ., 2020).…”

“…Cofactors such as dietary nitrosamines could significantly facilitate the pathology in question (Fig. 3) (Boonmars et al ., 2009; Sripa et al ., 2012 a ; Maksimova et al ., 2017; Mordvinov et al ., 2021).…”

“…The generally accepted model for studying opisthorchiasis caused by O. felineus and O. viverrini is the Syrian hamster Mesocricetus auratus (Waterhouse, 1839) (Fig. 2D-G) (Sripa et al, 2012a;Mordvinov et al, 2017bMordvinov et al, , 2021Pakharukova et al, 2018Pakharukova et al, , 2019aPakharukova et al, , 2019bPakharukova et al, , 2019cPakharukova et al, , 2021Arunsan et al, 2019;Zaparina et al, 2021). These animals are susceptible to infection by liver flukes, which is not surprising because the main reservoir animal of O. felineus is the muskrat, of the Cricetidae family closely related to Syrian hamsters (Fedorov, 1979;Fedorov et al, 1989).…”

Global changes in gene expression related to Opisthorchis felineus liver fluke infection reveal temporal heterogeneity of a mammalian host response

“…Other co-factors as dietary nitrosamines could strongly facilitate the carcinogenicity ( Maksimova et al, 2017 ; Mordvinov et al, 2021 ; Sripa et al, 2012 ). In such studies, hamsters infected with OF and receiving subcarcinogenic doses of dimethylnitrosamine develop cholangiocarcinoma, whereas those subjected to OF infection alone do not.…”

“…According to various estimates, the infection with OF in the rural population of Western Siberia varies from 10% to 60% ( Brazhnikova and Tolkaeva, 2002 ; Fedorova et al, 2020 ; Pakharukova and Mordvinov, 2016 ). The association of OF infection and cholangiocarcinoma development has been proven in an experimental animal model ( Maksimova et al, 2017 ; Mordvinov et al, 2021 ; Pakharukova et al, 2019a ). There are also reports that the incidence of cancer of the liver (e.g., of intrahepatic bile ducts) is higher in the endemic areas of the Russian Federation than in nonendemic regions ( Fedorova et al, 2016 ; reviewed in Pakharukova and Mordvinov, 2016 ).…”