A turn on fluorescent sensor for detecting Al3+ and colorimetric detection for Cu2+: Synthesis, cytotoxicity and on-site assay kit

A selective chromone‐based colorimetric chemosensor for detecting Cu2+ in near‐perfect aqueous solution and test kit

“…CMF was synthesized by the coupling reaction between furan-2-carbohydrazide and 4-oxo-4H-chromene-3-carbaldehyde (Scheme 1). CMF was affirmed by 1 H NMR, 13 C NMR, and ESI-mass (Figures S1-S3).…”

“…Dimethyl sulfoxide (DMSO) and methyl alcohol were purchased from SAMCHUN, Korea. 1 H and 13 C NMR data were provided with a Varian spectrometer. ESI-mass and absorption data were afforded with ACQUITY QDa and a Perkin Elmer spectrometer, respectively.…”

“…Copper ions are pivotal to the basic physiological functions of the human body such as a catalytic role for melanin production, mitochondrial electron transfer, red blood cell production, enzyme function, and neurotransmitter role [6][7][8][9][10]. However, low or excessive concentrations of Cu 2+ in body could induce diversely serious troubles like arthritis, Parkinson's disease, anemia, Wilson's disease, and Menkes syndrome [11][12][13][14]. Since copper ions could be accumulated in the human body through drinking water, therefore, the World Health Organization (WHO) has set a maximum permissible copper-ion level of 2 mg/L for drinking water [15][16][17].…”

An Acylhydrazone-Based Fluorescent Sensor for Sequential Recognition of Al3+ and H2PO4−

“…The excess amounts of 3-(tert-butyl)-2hydroxybenzaldehyde (1, 1.8 mmol) and 3-hydroxy-2-naphthohydrazide (2, 0.3 mmol) were mixed in absolute EtOH (10 mL) with a catalytic amount of HCl and stirred at room temperature for 1 day. A yellow precipitate was filtered, rinsed with cold absolute EtOH, and dried (77.2 mg, 70.1%); 1…”

“…Al 3+ , the third most abundant metallic element in nature [ 1 , 2 ], is broadly employed in daily life in packaging materials, pharmaceuticals, food additives, machinery, clinical medicines, and water purification [ 3 , 4 ]. Owing to its widespread usage, Al 3+ could be readily accumulated in the body, which leads to the development of diverse diseases such as Parkinson’s and Alzheimer’s disease [ 5 , 6 ].…”