A two-dimensional metallosupramolecular framework design based on coordination crosslinking of helical oligoamide nanorods

West, Norton G.; Seoudi, Rania S.; Barlow, Anders J.; Qi, Dongchen; Puškar, Ljiljana; Borgo, Mark P. Del; Kulkarni, Ketav; Adda, Christopher G.; Pan, Jisheng; Aguilar, Marie‐Isabel; Perlmutter, Patrick; Mechler, Ádám

doi:10.1039/d0ma00123f

Cited by 3 publications

(13 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The XPS measurements of 3H + metals were also compared with the addition of glutamic acid and imidazole to the metals, as these are the likely binding moieties of interest within 3H as previously identified. 17…”

Section: Methodsmentioning

confidence: 99%

“…As it was demonstrated before, incorporation of two α histidine residues between β 3 oligopeptide loops can lead to the formation of two dimensional sheets with copper as the coordinating metal. 17 Thus the self-assembly in this case leads to a hierarchical material.…”

Section: Introductionmentioning

confidence: 94%

“…6,10,13 The 14-helix allows for a greater number of internal hydrogen bonds between amide residues compared to α-helices, shielded from the chemical environment by the high density of side chains and thus leading to greater structural stability and a resistance to hydrolysis, enzymatic degradation and unwanted metal coordination. 14–17 The distinct faces of the helix can be functionalized by control of sequence. 18…”

Section: Introductionmentioning

confidence: 99%

“…The ability to incorporate payloads open avenues to implement a secondary self-assembly motif, such as a metal coordinating ligand. 17 Combining multiple motifs of self-assembly in a hierarchy allows for the construction of a more complex superstructures. As it was demonstrated before, incorporation of two α histidine residues between β 3 oligopeptide loops can lead to the formation of two dimensional sheets with copper as the coordinating metal.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Controllable hierarchical self-assembly: systematic study forming metallosupramolecular frameworks on the basis of helical beta-oligoamides

West,

Bamford,

Pigram

et al. 2023

Mater. Horiz.

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Controllable hierarchical self-assembly: systematic study forming metallosupramolecular frameworks on the basis of helical beta-oligoamides

West,

Bamford,

Pigram

et al. 2023

Mater. Horiz.

Self Cite

View full text Add to dashboard Cite

show abstract

“…For each sample, a wide spectrum (pass energy at 160 eV) and the Si 2p, O 1s, C 1s, and N 1s high resolution core lines (pass energy 20 eV) were recorded. The N 1s core line was best fitted in two components (~400.5 and ~399 eV [ 32 , 33 , 34 ]), named here as amino and non-amino to account for the surface density of amino groups added to the surface with the plasma treatments. Charge compensation was performed and the CH x component of the C 1s signal was set to 285 eV as the binding energy (BE) reference.…”

Section: Methodsmentioning

confidence: 99%

Tuning Surface Properties via Plasma Treatments for the Improved Capture of MicroRNA Biomarkers

et al. 2022

View full text Add to dashboard Cite

Advanced materials could bring about fundamental improvements in the evolution of innovative analytical devices, i.e., biosensors or lab-on-a-chip devices, in particular in the context of liquid biopsies. Here, plasma deposition processes were tested for the introduction of primary amines on silicon surfaces by tuning the amounts and availability of amino-charged residues. Different binary (CH4/NH3) and ternary (CH4/NH3/H2 and CH4/NH3/N2) mixtures of gases were used as feeds for the plasma treatments. The obtained surfaces were fully characterized for their chemical and physical properties before their use as capture materials in a functional test. Synthetic and fluorescently conjugated microRNA-21 (miR-21) was selected as the target molecule. The capture of miR-21 increased linearly with the increase in amino nitrogen measured on surfaces. The surface showing the most promising performance was further analyzed in different conditions, i.e., varying pH and time of incubation, incubation with different microRNAs, and possible elution of captured microRNAs. The apparent pH range of primary amines present on the surfaces was around 3.5–4. Positively charged surfaces prepared via PE-CVD were, therefore, demonstrated as being suitable materials for the capture of microRNA biomarkers, paving the way for their inclusion in biomedical devices for the purification and analysis of circulating biomarkers.

show abstract

Comprehensive multidimensional study of the self-assembly properties of a three residue substituted β³ oligoamide

Buchanan

Hinds

Puškar

et al. 2021

Pure and Applied Chemistry

View full text Add to dashboard Cite

Substituted β3 oligoamides form a unique self-assembling system where each monomer folds into a helix containing approximately three β3 amino acids per turn, yielding a geometrically well-defined cylindrical building block that, when N-acylated, is able to self-assemble head-to-tail into nanorods that can reach several 100 μm length. It was shown in previous works that self-assembly can be achieved with a three residue long oligoamide as well that lacks any intramolecular H-bonds, yet it crystallizes in a helix-like conformation. The self-assembly properties of these small oligoamides are however elusive, suggesting a more complex system than the self-assembly of the H-bond stabilized helical monomers. Here we focus on the self-assembly behaviour of a three residue oligoamide, Ac-β3[LIA] where the letters denote the side chain of the analogous α amino acid. Ac-β3[LIA] can yield highly inhomogeneous suspensions in water with a broad range of large fibrous structures that seem to be very stable, yet occasionally fibre growth is only observed upon heating. The small size of the monomer suggests a highly dynamic equilibrium yet all previous attempts failed to clearly identify low molecular weight species. Therefore a special methodology was employed in this study to characterize the suspensions at different size ranges: SANS that is optimal to measure the small oligomers and cross sectional diameter of the assemblies, DLS that is sensitive to the large populations and therefore the length of the superstructures, and NMR that is sensitive to monomeric and small oligomeric form, in conjunction with IR spectroscopy to probe the folding and AFM to image the morphology of the assemblies. Temperature ramping was used to perturb the system to probe the dynamicity of the self-assembly. It was found that the anomalous self-assembly behaviour of Ac-β3[LIA] is caused by its two stable conformations, a helix-building “horseshoe” fold and a linear conformer. The latter is exclusively found in monomeric form in solution whereas the horseshoe fold is stable in solid phase and in fibrous assemblies. Small oligomers were absent. Thus the self-assembly of Ac-β3[LIA] is arrested by the activation energy need of the conformation change; fibre growth might be triggered by conditions that allow increased conformational freedom of the monomers. This observation may be used to develop strategies for controlled switchable self-assembly.

show abstract

A two-dimensional metallosupramolecular framework design based on coordination crosslinking of helical oligoamide nanorods

Abstract:
Coordination crosslinking of oligoamide nanorods yields two dimensional metallosupramolecular framework.

Cited by 3 publications

References 47 publications

Controllable hierarchical self-assembly: systematic study forming metallosupramolecular frameworks on the basis of helical beta-oligoamides

Controllable hierarchical self-assembly: systematic study forming metallosupramolecular frameworks on the basis of helical beta-oligoamides

Tuning Surface Properties via Plasma Treatments for the Improved Capture of MicroRNA Biomarkers

Comprehensive multidimensional study of the self-assembly properties of a three residue substituted β³ oligoamide

Contact Info

Product

Resources

About

A two-dimensional metallosupramolecular framework design based on coordination crosslinking of helical oligoamide nanorods

Abstract: Coordination crosslinking of oligoamide nanorods yields two dimensional metallosupramolecular framework.

Cited by 3 publications

References 47 publications

Controllable hierarchical self-assembly: systematic study forming metallosupramolecular frameworks on the basis of helical beta-oligoamides

Controllable hierarchical self-assembly: systematic study forming metallosupramolecular frameworks on the basis of helical beta-oligoamides

Tuning Surface Properties via Plasma Treatments for the Improved Capture of MicroRNA Biomarkers

Comprehensive multidimensional study of the self-assembly properties of a three residue substituted β3 oligoamide

Contact Info

Product

Resources

About

Abstract:
Coordination crosslinking of oligoamide nanorods yields two dimensional metallosupramolecular framework.

Comprehensive multidimensional study of the self-assembly properties of a three residue substituted β³ oligoamide