A two-step synthetic strategy to obtain a water-soluble derivative of curcumin with improved antioxidant capacity and in vitro cytotoxicity in C6 glioma cells

New bow-tie cationic carbosilane dendritic system with a curcumin core as an anti-breast cancer agent

“…The results 1 obtained in the cell cycle did not show any significant number of cells in SubG0 phase (see Figure 2 3) indicating a non-apoptotic pathway. Similar results have been observed when curcumin was 3 dendronized with polyester dendrons of second generation where the mechanism of cellular death 4 was not apoptotic in C6 glioma cell line 32 . Analogously, other synthetic derivatives of curcumin 5 like hydrazinobenzoylcurcumin induced A549 cell autophagy.…”

“…properties, suggesting a different redox mechanism compared to the free curcumin. 32 In addition, intracellular ROS protection efficiency and free radical-scavenging activity of curcumin derivative 1 was also determined from an in vitro experiment in MFC-7 cell line by flow cytometry using the oxidant-sensing fluorescent probe 2',7'-dichlorodihydrofluorescein diacetate (DCFH-DA). It is possible to determine the levels of endogenous ROS formation when the oxidative stress was induced by tert-butyl hydroperoxide (TBHP).…”

“…Only one example has been described by modification of curcumin phenol groups with second-generation polyester dendrons and its antioxidant and cytotoxic capacity measured respecting free curcumin. 32 However, to our knowledge, no studies concerning carbosilane dendritic systems have been published.…”

Nanoemulsion Stabilized by Safe Surfactin from Bacillus subtilis as a Multifunctional, Custom-Designed Smart Delivery System

“…Numerous studies on curcumin indicate its anti-inflammatory, antioxidant and anticancer effects. After 24 h, curcumin reached an IC 50 < 200 μM against the NHDF cell line [ 50 ]. Some reports indicate that pure curcumin concentration for oncogene target inhibition and for the inhibitory effect on cancer cell proliferation is ∼15–20 μM [ 51 ].…”

“…Many properties related to their composition and physicochemical characteristics can influence their suitability and efficacy. A better understanding of these properties will help to extend the range of skin care product nanoformulations used in dermatology and cosmetics [ 50 ].…”