A type I and type II chemical biology toolbox to overcome the hypoxic tumour microenvironment for photodynamic therapy

Ju, Minzi; Yang, Lu; Wang, Guowei; Zong, Feng; Shen, Yu; Wu, Shuangshuang; Tang, Xuna; Yu, Decai

doi:10.1039/d4bm00319e

Biomater. Sci.

2024

DOI: 10.1039/d4bm00319e

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A type I and type II chemical biology toolbox to overcome the hypoxic tumour microenvironment for photodynamic therapy

Minzi Ju,

Lu Yang,

Guowei Wang

et al.

Abstract: Photodynamic therapy (PDT) is a minimally invasive therapeutic modality employed for the treatment of various types of cancers, localized infections, and other diseases. Upon illumination, the photo-excited photosensitizer generates singlet...

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Cited by 2 publications

References 62 publications

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Anthracene‐Based Endoperoxides as Self‐Sensitized Singlet Oxygen Carriers for Hypoxic‐Tumor Photodynamic Therapy

He,

Tang

2024

Adv Healthcare Materials

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Singlet oxygen is a crucial reactive oxygen species (ROS) in photodynamic therapy (PDT). However, the hypoxic tumor microenvironment limits the production of cytotoxic singlet oxygen through the light irradiation of PDT photosensitizers (PSs). This restriction poses a major challenge in improving the effectiveness of PDT. To overcome this challenge, researchers have explored the development of singlet oxygen carriers that can capture and release singlet oxygen in physiological conditions. Among these developments, anthracene‐based endoperoxides, initially discovered almost 100 years ago, have shown the ability to generate singlet oxygen controllably under thermal or photo stimuli. Recent advancements have led to the development of a new class of self‐sensitized anthracene‐endoperoxides, with potential applications in enhancing PDT effects for hypoxic tumors. This review discusses the current research progress in utilizing self‐sensitized anthracene‐endoperoxides as singlet oxygen carriers for improved PDT. It covers anthracene‐conjugated small organic molecules, metal–organic complexes, polymeric structures, and other self‐sensitized nano‐structures. The molecular structural designs, mechanisms, and characteristics of these systems will be discussed. This review aims to provide valuable insights for developing high‐performance singlet oxygen carriers for hypoxic‐tumor PDT.

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Anthracene‐Based Endoperoxides as Self‐Sensitized Singlet Oxygen Carriers for Hypoxic‐Tumor Photodynamic Therapy

He,

Tang

2024

Adv Healthcare Materials

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Enhancement of fluorescence and singlet oxygen production of berberine on clay Nanosheets by surface-fixation Induced emission (S-FIE)

Mori,

Yamashina,

Rasa Melechalil

et al. 2025

Journal of Photochemistry and Photobiology A: Chemistry

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A type I and type II chemical biology toolbox to overcome the hypoxic tumour microenvironment for photodynamic therapy

Abstract: Photodynamic therapy (PDT) is a minimally invasive therapeutic modality employed for the treatment of various types of cancers, localized infections, and other diseases. Upon illumination, the photo-excited photosensitizer generates singlet...

Cited by 2 publications

References 62 publications

Anthracene‐Based Endoperoxides as Self‐Sensitized Singlet Oxygen Carriers for Hypoxic‐Tumor Photodynamic Therapy

Anthracene‐Based Endoperoxides as Self‐Sensitized Singlet Oxygen Carriers for Hypoxic‐Tumor Photodynamic Therapy

Enhancement of fluorescence and singlet oxygen production of berberine on clay Nanosheets by surface-fixation Induced emission (S-FIE)

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