A Unidirectional DNA Walker That Moves Autonomously along a Track

Enthalpy‐Driven Three‐State Switching of a Superhydrophilic/Superhydrophobic Surface

“…Owing to the advantages of siteto-site molecular recognition, DNA molecules have been extensively investigated in the field of smart nucleic acid nanodevices. [12][13][14][15][16][17][18] Herein, we modified DNA with a fluoridecontaining hydrophobic group and immobilized it onto a gold surface through a gold-thoil bond to create an intelligent switching surface (Figure 1). It was envisaged that the DNA could conceal and expose the fluoride-containing hydrophobic group by virtue of a stimulus-responsive conformational change of the i-motif structure into an extended structure: either a stretched single-stranded structure or a double-stranded structure.…”

Molecular Motors: Synthetic DNA‐Based Walkers Inspired by Kinesin

“…A key feature of the kinesin system is that the direction of movement is controlled. The challenge of controlling directionality is perhaps best illustrated by considering the situation halfway between Figure [19][20][21][22] provide the first steps toward meeting this challenge. All of these use DNA-based systems.…”

“…[22] In this case, the walker, a six-nucleotide fragment colored red and indicated by * in Figure 6, moves along a DNA track, but it is more like a bucket being passed along a bucket brigade (or a crowd surfer being transported across a mosh pit). Here too, the process is unidirectional, but instead of using set and unset strands, T4 ligase accomplishes the set function and creates, at the same time, a recognition site for restriction endonucleases (PflM I, BstAP I) Figure 4.…”

“…Figure 6. Operation of the device by Yan, Turberfield, Reif, and coworkers [22] (see text for details). The green and pink arrows indicate the sites of restriction; the purple \/[ symbols show where ligation occurs.…”

Künstliche molekulare Motoren auf DNA‐Basis nach dem Vorbild von Kinesin

“…Yan, Turberfield, Reif und Mitarbeiter berichteten kürzlich über eine dritte Strategie. [22] Hier bewegt sich ein 6-Nucleotid-Fragment ( * , rot in Abbildung 6) entlang eines DNA-Laufwegs fort. Jedoch gleicht diese Bewegung mehr dem Transport eines Eimers in einer Eimerkette (oder dem eines gefeierten Stars, der von einer Menschenmenge auf Händen getragen wird).…”