A Unique Case of Central Hypopituitarism and Central Diabetes Insipidus Caused By Diffuse Large B-Cell Lymphoma

Abstract

Objective: To present the case of a 39-year-old male admitted to the hospital with diabetes insipidus as a sequela of a previously undiagnosed diffuse large B-cell lymphoma. This case is unique, as the patient's disease was determined to be an infiltrative malignancy affecting the pituitary infundibular stalk, resulting in multifocal pituitary dysfunction.Methods: Case report.Results: Initially presenting with gastrointestinal bleed, later discovered to be from tumor infiltration of gastric vessels, diagnosis of lymphoma was made when gastrectomy became necessary for hemostasis.

Central Diabetes Insipidus in a Patient With Lymphoma: A Case Report

“…Primary CNS lymphoma and secondary infiltrative lymphoma can infiltrate the hypothalamus and induce CDI with panhypopituitarism [ 9 , 12 ]. Moreover, lymphoma can infiltrate the pituitary stalk, depicted as thickening in imaging studies and causing hypopituitarism along with CDI [ 13 ]. Infiltration of the pituitary stalk by lymphomas may also have a specific V-shaped pattern in magnetic resonance imaging (MRI) [ 14 ].…”

“…Primary CNS lymphoma and secondary infiltrative lymphoma can infiltrate the hypothalamus and induce CDI with panhypopituitarism [9,12]. Moreover, lymphoma can infiltrate the pituitary stalk, depicted as thickening in imaging studies and causing hypopituitarism along with CDI [13].…”