A unique case of clear cell variant of calcifying epithelial odontogenic tumor involving the maxilla

Chatterjee, Rudra Prasad; Gayen, Swagata; Kundu, S. S.; Chattaraj, Moumita; Pal, Mousumi; Das, Sanjeet Kumar

doi:10.4103/1735-3327.211623

Cited by 4 publications

(5 citation statements)

References 12 publications

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“…[20][21][22]27,47 The lesion is extensive to the maxillary sinus and the nasal cavity and causes displacement of the eye globe, similar to the characteristics observed in our case. Chatterjee et al 22 illustrated an example of CCCEOT involving the left side of the middle third of the face in a 73-year-old female individual who refused to undergo any surgery due to her age. Munteanu et al 21 described a 45-year-old female individual with a diffuse swelling of the left maxilla that showed extension and involvement of the alveolar process, maxillary sinus, and palatine process.…”

Section: Discussionsupporting

confidence: 71%

“…3,4 This rare variant has been acknowledged as more aggressive when compared with the conventional CEOT. 4,[19][20][21][22] However, in a recent systematic review, 4 CCCEOT was reported to be associated with demographic data and behavior similar to CEOT, suggesting that the presence of clear cells has no substantial clinical significance and does not support the separation of this histological variant as a distinct category. According to Jain et al, 23 CCCEOT exhibits a biphasic histological pattern quite consistent with the areas of diagnosis of the lesion in question and other areas with conspicuous clear cell component.…”

Section: Discussionmentioning

confidence: 99%

“…3,26 Flecks of radiopaque calcifications, with "driven snow" appearance, may also lead to the suspicious of CEOT. 26 Among the CCCEOT affecting the posterior region of the maxilla, [20][21][22]27 lesions with radiopaque foci resemble benign fibrous-osseous lesion, AOT, COC, as well COF, regardless of their predilection for the mandible.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, immunostaining of the epithelial component was intense, diffuse, and with positivity for AE1/AE3, CK-14, and CK-19, as documented previously. 22,28,46 When CCCEOT affects the posterior maxilla, aggressiveness has been commonly observed. [20][21][22]27,47 The lesion is extensive to the maxillary sinus and the nasal cavity and causes displacement of the eye globe, similar to the characteristics observed in our case.…”

Section: Discussionmentioning

confidence: 99%

“…22,28,46 When CCCEOT affects the posterior maxilla, aggressiveness has been commonly observed. [20][21][22]27,47 The lesion is extensive to the maxillary sinus and the nasal cavity and causes displacement of the eye globe, similar to the characteristics observed in our case. Chatterjee et al 22 illustrated an example of CCCEOT involving the left side of the middle third of the face in a 73-year-old female individual who refused to undergo any surgery due to her age.…”

Section: Discussionmentioning

confidence: 99%

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A Rare Case of an Aggressive Clear Cell Variant of Calcifying Epithelial Odontogenic Tumor in the Posterior Maxilla

et al. 2020

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A clear cell variant of calcifying epithelial odontogenic tumor is a rare benign odontogenic neoplasm, accounting for 33 cases described in the literature. In this article, we report a challenging example of clear cell variant of calcifying epithelial odontogenic tumor of the posterior maxilla in a 45-year-old female patient showing locally aggressive growth and recurrence. Microscopically, islands of polyhedral cells containing abundant cytoplasm, well-developed intercellular bridges blended with clear cells were observed. The nuclei were frequently pleomorphic and permeated by hyaline calcified material. Immunohistochemistry revealed positivity for pan-cytokeratin (AE1/AE3), cytokeratins (CK-14 and CK-19), Bcl-2, p53, and p63. The Ki-67 proliferative index was ~10%. As odontogenic tumors are rare, when a significant clear cell component is observed, the differential diagnosis with other lesions of the jaws with similar morphology, including other odontogenic tumors with prominent clear cell component, clear cell odontogenic carcinomas, and metastatic tumors, is difficult.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Rare Case of an Aggressive Clear Cell Variant of Calcifying Epithelial Odontogenic Tumor in the Posterior Maxilla

et al. 2020

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CEOT Variants or Entities: Time for a Rethink? A Case Series with Review of the Literature

Siriwardena

Speight

Franklin

et al. 2020

Head and Neck Pathol

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The first detailed description of calcifying epithelial odontogenic tumor (CEOT) are ascribed to Jens Pindborg, but this tumor was described some years previously. Subsequently, CEOT was included in the 1971 WHO classification of odontogenic tumors and a since then number of variants have been described, which have added confusion to the diagnostic criteria. We aimed to survey the literature on the variants of CEOT, in parallel with a review of our single institution experience of CEOTs. Cases identified were collated, including available clinical, radiological and histological information and then reviewed, taking into account changes in the understanding and classifications of odontogenic tumors since initial diagnosis. We identified 26 cases from 1975 to 2017 for which histological material was available. Of these, only 13 (50%) showed the "classic" histological appearance, whilst two cases were identified as recognized variants. In 11 cases, other diagnoses or a differential diagnosis were preferred, with no agreed diagnosis in four of these. The proliferation fraction (Ki67) in the 10 cases tested was 2.1% ± 0.18. These findings illustrate the diagnostic challenges in this group of tumors and highlight the gaps in knowledge. Techniques, such as EWSR1 gene cytogenetic analysis, may be helpful in cases with clear cells. However, in other areas of controversy, including the non-calcifying and Langerhans cell rich variants, further investigation, perhaps utilizing sequencing technologies may be needed to refine the classification. Owing to the relative rarity of these lesions it would be beneficial if future work could be pursued as an international collaboration.

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Clinical, radiological and histological features of an unique case of calcifying epithelial odontogenic tumor

Sarkar¹,

Gayen²,

Kundu³

et al. 2019

J Oral Maxillofac Pathol

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A unique case of clear cell variant of calcifying epithelial odontogenic tumor involving the maxilla

Cited by 4 publications

References 12 publications

A Rare Case of an Aggressive Clear Cell Variant of Calcifying Epithelial Odontogenic Tumor in the Posterior Maxilla

A Rare Case of an Aggressive Clear Cell Variant of Calcifying Epithelial Odontogenic Tumor in the Posterior Maxilla

CEOT Variants or Entities: Time for a Rethink? A Case Series with Review of the Literature

Clinical, radiological and histological features of an unique case of calcifying epithelial odontogenic tumor

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