A Universal Transvaginal Cervical Length Screening Program for Preterm Birth Prevention

Orzechowski, Kelly; Boelig, Rupsa C.; Baxter, Jason K.; Berghella, Vincenzo

doi:10.1097/aog.0000000000000428

Cited by 88 publications

(75 citation statements)

References 10 publications

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“…In sensitivity analysis we allowed these incidence estimates to vary based on prior studies and as such the incidence of a short cervix varied from 0.2-1.9% and a midlength cervix from 0-8.7%. 1,2,[7][8][9] The preterm birth rates used in the model were inversely related to CL. The overall incidence of preterm birth <34 weeks' gestation was estimated at 1.3%; this also was based on data provided by Orzechowski et al 7 for their unscreened population.…”

Section: Methodsmentioning

confidence: 99%

Cost-effectiveness of transvaginal ultrasound cervical length screening in singletons without a prior preterm birth: an update

Werner

Hamel

Orzechowski

et al. 2015

American Journal of Obstetrics and Gynecology

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Section: Methodsmentioning

confidence: 99%

Cost-effectiveness of transvaginal ultrasound cervical length screening in singletons without a prior preterm birth: an update

Werner

Hamel

Orzechowski

et al. 2015

American Journal of Obstetrics and Gynecology

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“…Nevertheless, the prevalence of a short cervical length and its sensibility for the detection of spontaneous preterm birth are extremely low [7][8][9] . Consequently, only a small proportion of pregnant women are identified as being at high risk of preterm delivery and potentially benefit from the treatments available [10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

Quantitative Analysis of the Cervical Texture by Ultrasound and Correlation with Gestational Age

Baños

Perez‐Moreno²,

Triginer³

et al. 2016

Fetal Diagn Ther

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Objectives: Quantitative texture analysis has been proposed to extract robust features from the ultrasound image to detect subtle changes in the textures of the images. The aim of this study was to evaluate the feasibility of quantitative cervical texture analysis to assess cervical tissue changes throughout pregnancy. Methods: This was a cross-sectional study including singleton pregnancies between 20.0 and 41.6 weeks of gestation from women who delivered at term. Cervical length was measured, and a selected region of interest in the cervix was delineated. A model to predict gestational age based on features extracted from cervical images was developed following three steps: data splitting, feature transformation, and regression model computation. Results: Seven hundred images, 30 per gestational week, were included for analysis. There was a strong correlation between the gestational age at which the images were obtained and the estimated gestational age by quantitative analysis of the cervical texture (R = 0.88). Discussion: This study provides evidence that quantitative analysis of cervical texture can extract features from cervical ultrasound images which correlate with gestational age. Further research is needed to evaluate its applicability as a biomarker of the risk of spontaneous preterm birth, as well as its role in cervical assessment in other clinical situations in which cervical evaluation might be relevant.

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“…1 Over the last few years, cervical assessment has moved from digital examination to ultrasound evaluation, and ultrasound of the cervix has been the focus of much research. [5][6][7][8] Transvaginal ultrasound (TVU) cervical length (CL) has been assessed in several populations (e.g. asymptomatic women as well as women with symptoms of preterm labour) 5,9 to evaluate the risk of preterm birth, 10 and in women before induction of labour to predict induction outcome.…”

Section: Introductionmentioning

confidence: 99%

“…[5][6][7][8] Transvaginal ultrasound (TVU) cervical length (CL) has been assessed in several populations (e.g. asymptomatic women as well as women with symptoms of preterm labour) 5,9 to evaluate the risk of preterm birth, 10 and in women before induction of labour to predict induction outcome. 11,12 Many observational studies have evaluated the association between TVU CL at term and the interval to delivery.…”

Section: Introductionmentioning

confidence: 99%

Transvaginal ultrasound cervical length for prediction of spontaneous labour at term: a systematic review and meta‐analysis

Saccone

Simonetti

Berghella

2015

BJOG

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Background The possibility to predict the delivery date is a question frequently raised by pregnant women. However, a clinician has currently little to predict when a woman at term will deliver.Objective To evaluate the predictive accuracy of transvaginal ultrasound (TVU) cervical length (CL) for spontaneous onset of labour in singleton gestation enrolled at term by a meta-analysis.Search strategy We performed a literature search in electronic databases. Selection criteriaWe included only studies assessing the accuracy of TVU CL in prediction of spontaneous onset of labour in singleton gestations with vertex presentation who were enrolled at term.Data collection and analysis The primary outcome was the accuracy of CL for prediction of spontaneous labour within 7 days. Pooled sensitivities and specificities were calculated.Main results Five studies including 735 singleton gestations were included. For the prediction of spontaneous labour within 7 days for CL <30 mm the pooled sensitivity was 64% and pooled specificity was 60%. The higher the CL, the better the sensitivity; the lower the CL, the better the specificity. A woman with a singleton gestation at term and a TVU CL of 30 mm has a <50% chance of delivering within 7 days, while one with a TVU CL of 10 mm has an over 85% chance of delivery within 7 days.Conclusions TVU CL at term has moderate value in predicting the onset of spontaneous labour. A woman with a TVU CL of 10 mm or less has a high chance of delivering within a week.Tweetable abstract Cervical length at term has moderate value in predicting the onset of spontaneous labour.

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A Universal Transvaginal Cervical Length Screening Program for Preterm Birth Prevention

Cited by 88 publications

References 10 publications

Cost-effectiveness of transvaginal ultrasound cervical length screening in singletons without a prior preterm birth: an update

Cost-effectiveness of transvaginal ultrasound cervical length screening in singletons without a prior preterm birth: an update

Quantitative Analysis of the Cervical Texture by Ultrasound and Correlation with Gestational Age

Transvaginal ultrasound cervical length for prediction of spontaneous labour at term: a systematic review and meta‐analysis

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