A urinary metabolomics study of the metabolic dysfunction and the regulation effect of citalopram in rats exposed to chronic unpredictable mild stress

Yu, Xinyu; Jia, Luo; Chen, Lijun; Zhang, Chengxiang; Zhang, Rutan; Hu, Qi; Qiao, Shubin; Li, Lei

doi:10.1039/c5ra10668k

Cited by 8 publications

(2 citation statements)

References 60 publications

(59 reference statements)

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“…Accumulated evidence shows that ROS-induced oxidative stress is the key factor in inducing natural age-related changes 33 . D-gal induces ageing alterations that are similar to the normal ageing processes 34 , 35 . It has been confirmed in previous studies that oxidative stress could result in apoptosis, which is the main cause of many types of organ damage.…”

Section: Discussionmentioning

confidence: 82%

Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose

Chen

Zhou

2018

Sci Rep

145

104

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Accumulating evidence has suggested that oxidative stress and apoptosis are involved in the ageing process. D-galactose (gal) has been reported to cause symptoms of ageing in rats, accompanied by liver and brain injuries. Our study aimed to investigate the potential antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid and to explore how these effects act on rats in a D-gal-induced ageing model. Ageing was induced by subcutaneous injection of D-gal (100 mg/kg/d for 8 weeks). Ellagic acid was simultaneously administered to the D-gal-induced ageing rats once daily by intragastric gavage. Finally, the mental condition, body weight, organ index, levels of inflammatory cytokines, antioxidative enzymes, and liver function, as well as the expression of pro- and anti-apoptotic proteins, were monitored. Our results showed that ellagic acid could improve the mental condition, body weight, organ index and significantly decrease the levels of inflammatory cytokines, normalize the activities of antioxidative enzymes, and modulate the expression of apoptotic protein in ageing rats. In conclusion, the results of this study illustrate that ellagic acid was suitable for the treatment of some ageing-associated problems, such as oxidative stress, and had beneficial effects for age-associated diseases.

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Section: Discussionmentioning

confidence: 82%

Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose

Chen

Zhou

2018

Sci Rep

145

104

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“…It has been applied for capturing disease-specic metabolomic signatures and then searching for potential biomarkers in combination with multivariate statistical methods which can provide new insight into deeper understanding of the pathological mechanisms for diseases. 5,8 In previous research, our group has successfully established a urine-based metabolic proling approach in CUMS rats by UPLC-MS, 9 however, current researches are mostly focused on a single sample such as urine, plasma or the brain tissue which can't reect the dynamic and systemic metabolic changes in the pathological process of MDD.…”

Section: Introductionmentioning

confidence: 99%

A metabolomics-based approach for ranking the depressive level in a chronic unpredictable mild stress rat model

Qiao

Wang

et al. 2016

RSC Adv.

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Urine NMR Metabolomic Study on Biochemical Activities to Investigate the Effect of P. betle Extract on Obese Rats

Ghani

Rashid²,

Shaari

et al. 2019

Appl Biochem Biotechnol

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The present studies are to evaluate the ability of PB to induce weight loss and urine metabolite profile of Piper betle L. (PB) leaf extracts using metabolomics approach. Dried PB leaves were extracted with ethanol 70% and the studies were performed in different groups of rats fed with high fat (HFD) and normal diet (ND). Then, fed with the PB extract with 100, 300, and 500 mg/kg and two negative control groups given water (WTR). The body weights were monitored and evaluated. Urine was collected and 1H NMR-based metabolomics approach was used to detect the metabolite changes. Results showed that PB-treated group demonstrated inhibition of body weight gain. The trajectory of urine metabolites showed that PB-treated group gave the different distribution from week 12 to 16 compared with the control groups. In 1H NMR metabolomic approach analysis, the urine metabolites gave the best separation in principle component 1 and 3, with 40.0% and 9.56% of the total variation. Shared and unique structures (SUS) plot model showed that higher concentration PB-treated group was characterized by high level of indole-3-acetate, aspartate, methanol, histidine, and creatine, thus caused an increased the metabolic function and maintaining the body weight of the animals treated.

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A urinary metabolomics study of the metabolic dysfunction and the regulation effect of citalopram in rats exposed to chronic unpredictable mild stress

Abstract: This is the first attempt to combine the exploration of biomarkers of depression and evaluating the effect of citalopram by a metabolomics method, and then use the method to access the depression status according to the changed metabolome.

Cited by 8 publications

References 60 publications

Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose

Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose

A metabolomics-based approach for ranking the depressive level in a chronic unpredictable mild stress rat model

Urine NMR Metabolomic Study on Biochemical Activities to Investigate the Effect of P. betle Extract on Obese Rats

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