A user-guide for polymer purification using dialysis

Schuett, Timo; Anufriev, Ilya; Endres, Patrick; Stumpf, Steffi; Nischang, Ivo; Hoeppener, Stephanie; Zechel, Stefan; Schubert, Ulrich S.; Geitner, Robert

doi:10.1039/d2py00972b

Cited by 4 publications

(5 citation statements)

References 42 publications

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“…Recent studies on polymer diffusion kinetics during dialysis have revealed crucial influence of chemical composition on polymer retention. , Given the inherent sequence heterogeneity of RHPs, it naturally leads to the question of whether certain RHP chains are removed during the purification process (Scheme ). Thus, we monitored the composition evolution of RHP1–4 at every stage of the preparation process (Figure a, synthesis details in Section S2).…”

Section: Resultsmentioning

confidence: 99%

Mapping Composition Evolution through Synthesis, Purification, and Depolymerization of Random Heteropolymers

Yu,

Liu,

Yin

et al. 2024

J. Am. Chem. Soc.

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Random heteropolymers (RHPs) consisting of three or more comonomers have been routinely used to synthesize functional materials. While increasing the monomer variety diversifies the sidechain chemistry, this substantially expands the sequence space and leads to ensemble-level sequence heterogeneity. Most studies have relied on monomer composition and simulated sequences to design RHPs, but the questions remain unanswered regarding heterogeneities within each RHP ensemble and how closely these simulated sequences reflect the experimental outcomes. Here, we quantitatively mapped out the evolution of monomer compositions in four-monomer-based RHPs throughout a design-synthesis-purification-depolymerization process. By adopting a Jaacks method, we first determined 12 reactivity ratios directly from quaternary methacrylate RAFT copolymerization experiments to account for the influences of competitive monomer addition and the reversible activation/deactivation equilibria. The reliability of in silico analysis was affirmed by a quantitative agreement (<4% difference) between the simulated RHP compositions and the experimental results. Furthermore, we mapped out the conformation distribution within each ensemble in different solvents as a function of monomer chemistry, composition, and segmental characteristics via high-throughput computation based on selfconsistent field theory (SCFT). These comprehensive studies confirmed monomer composition as a viable design parameter to engineer RHP-based functional materials as long as the reactivity ratios are accurately determined and the livingness of RHP synthesis is ensured.

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Section: Resultsmentioning

confidence: 99%

Mapping Composition Evolution through Synthesis, Purification, and Depolymerization of Random Heteropolymers

Yu,

Liu,

Yin

et al. 2024

J. Am. Chem. Soc.

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“…39 This system is based on a benchtop NMR device, which already gained much interest in academic research. [40][41][42][43] By the use of ow cells, a continuous circulation of the reaction solution through the analytical capillary is possible. 44 Therefore, no sampling process is required and, thus, the spectroscopic technique does not affect the catalytic system.…”

Section: Cooperative Effectmentioning

confidence: 99%

Investigation of the cooperative-effects of Lewis- and Brønstedt acids in homogeneously catalyzed OME fuel synthesis by inline-NMR monitoring

Endres,

Schuett,

Zechel

et al. 2024

RSC Adv.

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“…the influence of polymers on the purification rate, [78] but also the fully automated synthesis of block copolymers with incomplete conversion during the reactions. [79] First, a polymer was produced using RAFT polymerization in the synthesis robot, purified, and then converted into the block copolymer in the synthesis robot.…”

Section: Purificationmentioning

confidence: 99%

“…As a result, the reaction mixture could be automatically transferred to the dialysis directly after the reaction and back again after the purification was completed. In addition, a corresponding approach could also be linked to monitoring using online NMR spectroscopy, which enabled the investigation of kinetics [ 77 ] and the influence of polymers on the purification rate, [ 78 ] but also the fully automated synthesis of block copolymers with incomplete conversion during the reactions. [ 79 ] First, a polymer was produced using RAFT polymerization in the synthesis robot, purified, and then converted into the block copolymer in the synthesis robot.…”

Section: Polymer Synthesismentioning

confidence: 99%

Application of Digital Methods in Polymer Science and Engineering

Schuett,

Endres,

Standau

et al. 2023

Adv Funct Materials

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The development of new polymer materials is an emerging field for more than 100 years. However, it is currently facing major challenges and the application of digital methods can help to develop new processes, discover new materials and, thus, contribute to the challenges of today and the future. Though, the application of digital methods in the field of polymer science is currently very limited, when compared to other classes of materials such as small molecules or inorganic high‐performance materials. Nevertheless, there are already first, very promising approaches. The current review article focuses on the application of these methods in different aspects of polymer research including polymer design, synthesis, and characterization. Furthermore, the digital discovery of polymer engineering is highlighted in detail showing the broad range of potential applications of these methods in polymer science. Finally, future possibilities and opportunities are derived from the current state‐of‐the‐art and perspectives for a potential evolution of polymer science are provided.

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A user-guide for polymer purification using dialysis

Abstract: Dialysis diffusion kinetics are performed via in-situ NMR spectroscopy for numerous different raw polymeric solutions to result in a general guideline for polymer purification using dialysis. In several approaches, a...

Cited by 4 publications

References 42 publications

Mapping Composition Evolution through Synthesis, Purification, and Depolymerization of Random Heteropolymers

Mapping Composition Evolution through Synthesis, Purification, and Depolymerization of Random Heteropolymers

Investigation of the cooperative-effects of Lewis- and Brønstedt acids in homogeneously catalyzed OME fuel synthesis by inline-NMR monitoring

Application of Digital Methods in Polymer Science and Engineering

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